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26 results

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Page 1
Relationship of ZNF423 and CTSO with breast cancer risk in two randomised tamoxifen prevention trials.
Brentnall AR, Cuzick J, Byers H, Segal C, Reuter C, Detre S, Sestak I, Howell A, Powles TJ, Newman WG, Dowsett M. Brentnall AR, et al. Breast Cancer Res Treat. 2016 Aug;158(3):591-6. doi: 10.1007/s10549-016-3885-x. Epub 2016 Jul 11. Breast Cancer Res Treat. 2016. PMID: 27400912 Free PMC article.
The OncoArray was used for genotyping and included two SNPs previously identified (rs8060157 in ZNF423 and rs10030044 near CTSO), and 102 further SNPs within the same regions. Overall, there were 369 cases and 662 controls, with 148 cases and 268 controls from the tamoxife …
The OncoArray was used for genotyping and included two SNPs previously identified (rs8060157 in ZNF423 and rs10030044 near CTSO), and …
Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
Santamaría I, Pendás AM, Velasco G, López-Otín C. Santamaría I, et al. Genomics. 1998 Oct 15;53(2):231-4. doi: 10.1006/geno.1997.5180. Genomics. 1998. PMID: 9790772
The human gene encoding cathepsin O, a cysteine proteinase from the papain superfamily, has been cloned and its overall organization established. The gene (HGMW-approved symbol CTSO) is composed of eight coding exons and seven introns and spans more than 30 kb. The number …
The human gene encoding cathepsin O, a cysteine proteinase from the papain superfamily, has been cloned and its overall organization establi …
Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.
Hato Y, Kondo N, Yoshimoto N, Endo Y, Asano T, Dong Y, Nishimoto M, Takahashi S, Fujii Y, Nakanishi R, Toyama T. Hato Y, et al. Int J Clin Oncol. 2016 Jun;21(3):539-47. doi: 10.1007/s10147-015-0913-5. Epub 2015 Oct 19. Int J Clin Oncol. 2016. PMID: 26482374
TaqMan pre-designed SNP genotyping assays were used to identify the presence of CTSO rs10030044 and ZNF423 rs8060157. We then investigated the relationship between CTSO rs10030044 genotypes and mRNA expression levels of CTSO and BRCA1 in 290 breast cancer pat …
TaqMan pre-designed SNP genotyping assays were used to identify the presence of CTSO rs10030044 and ZNF423 rs8060157. We then investi …
SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERalpha-positive breast cancer through regulation of BRCA1.
Cairns J, Ingle JN, Wickerham LD, Weinshilboum R, Liu M, Wang L. Cairns J, et al. PLoS Genet. 2017 Oct 2;13(10):e1007031. doi: 10.1371/journal.pgen.1007031. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 28968398 Free PMC article.
We report that CTSO reduces the protein levels of BRCA1 and ZNF423 through cysteine proteinase-mediated degradation. We also have identified a series of transcription factors of BRCA1 that are regulated by CTSO at the protein level. Importantly, the variant CTSO …
We report that CTSO reduces the protein levels of BRCA1 and ZNF423 through cysteine proteinase-mediated degradation. We also have ide …
Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes.
Liu D, Ho MF, Schaid DJ, Scherer SE, Kalari K, Liu M, Biernacka J, Yee V, Evans J, Carlson E, Goetz MP, Kubo M, Wickerham DL, Wang L, Ingle JN, Weinshilboum RM. Liu D, et al. NPJ Breast Cancer. 2017 Aug 21;3:30. doi: 10.1038/s41523-017-0036-4. eCollection 2017. NPJ Breast Cancer. 2017. PMID: 28856246 Free PMC article.
Our previous GWAS using samples from the NSABP P-1 and P-2 selective estrogen receptor modulator (SERM) breast cancer prevention trials identified SNPs in ZNF423 and near CTSO that were associated with breast cancer risk during SERM chemoprevention. ...Our study utilized a …
Our previous GWAS using samples from the NSABP P-1 and P-2 selective estrogen receptor modulator (SERM) breast cancer prevention trials iden …
Proteome profiling identifies circulating biomarkers associated with hepatic steatosis in subjects with Prader-Willi syndrome.
Pascut D, Giraudi PJ, Banfi C, Ghilardi S, Tiribelli C, Bondesan A, Caroli D, Minocci A, Grugni G, Sartorio A. Pascut D, et al. Front Endocrinol (Lausanne). 2023 Nov 15;14:1254778. doi: 10.3389/fendo.2023.1254778. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 38034016 Free PMC article.
Receiver operating characteristic (ROC) curves assessed the discriminatory power of circulating protein while a logistic regression model evaluated the potential of a combination of protein biomarkers. RESULTS: CDH2, CTSO, QDPR, CANT1, ALDH1A1, TYMP, ADGRE, KYAT1, MCFD, SE …
Receiver operating characteristic (ROC) curves assessed the discriminatory power of circulating protein while a logistic regression model ev …
Comparison of Bilateral Cerebro-Renal Tissue Oxygenations in Healthy Children.
Öztürk NY, Aygün B, Uyar E, Girgin Fİ. Öztürk NY, et al. Indian J Pediatr. 2020 Feb;87(2):99-104. doi: 10.1007/s12098-019-03093-1. Epub 2019 Dec 26. Indian J Pediatr. 2020. PMID: 31879839
OBJECTIVE: To investigate right and left cerebral tissue (ctSO(2)) and renal tissue oxygenations (rtSO(2)) in otherwise healthy children. ...RESULTS: The median age was 6.7 y (IQR 3-10.4) and median weight was 21 kg (IQR 13-33). Right and left sided ctSO(2) and rtSO …
OBJECTIVE: To investigate right and left cerebral tissue (ctSO(2)) and renal tissue oxygenations (rtSO(2)) in otherwise healthy child …
Epidemiology of accelerometer-based sleep parameters in US school-aged children and adults: NHANES 2011-2014.
Su S, Li X, Xu Y, McCall WV, Wang X. Su S, et al. Sci Rep. 2022 May 10;12(1):7680. doi: 10.1038/s41598-022-11848-8. Sci Rep. 2022. PMID: 35538108 Free PMC article.
Sleep duration showed a U-shaped association with age and reached the minimum at age 40 and started to increase again around age 50. The clock time for sleep onset (CTSO) delayed with age and reached the maximum at about age 20. CTSO then advanced until age 50, leve …
Sleep duration showed a U-shaped association with age and reached the minimum at age 40 and started to increase again around age 50. The clo …
Bioinformatics analysis of the key genes in osteosarcoma metastasis and immune invasion.
Liang J, Chen J, Hua S, Qin Z, Lu J, Lan C. Liang J, et al. Transl Pediatr. 2022 Oct;11(10):1656-1670. doi: 10.21037/tp-22-402. Transl Pediatr. 2022. PMID: 36345453 Free PMC article.
., ecotropic viral integration site 2B (EVI2B), CCAAT/enhancer binding protein (CEBPA), lymphocyte cytosolic protein 2 (LCP2), selectin L (SELL), and Niemann-Pick disease, type C2A (NPC2A)], and a prognostic model with 4 genes [i.e., insulin-like growth factors-2 (IGF2), cathepsi …
., ecotropic viral integration site 2B (EVI2B), CCAAT/enhancer binding protein (CEBPA), lymphocyte cytosolic protein 2 (LCP2), selectin L (S …
Integrating single-cell and bulk transcriptomic analyses to develop a cancer-associated fibroblast-derived biomarker for predicting prognosis and therapeutic response in breast cancer.
Li C, Yang L, Zhang Y, Hou Q, Wang S, Lu S, Tao Y, Hu W, Zhao L. Li C, et al. Front Immunol. 2024 Jan 3;14:1307588. doi: 10.3389/fimmu.2023.1307588. eCollection 2023. Front Immunol. 2024. PMID: 38235137 Free PMC article.
RESULTS: Integrated analyses of single-cell and bulk transcriptomic data as well as prognostic screening revealed a total of 43 prognostic CAFRGs; of which, 14 genes (TLN2, SGCE, SDC1, SAV1, RUNX1, PDLIM4, OSMR, NT5E, MFAP4, IGFBP6, CTSO, COL12A1, CCDC8 and C1S) were ident …
RESULTS: Integrated analyses of single-cell and bulk transcriptomic data as well as prognostic screening revealed a total of 43 prognostic C …
26 results