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Year Number of Results
1987 1
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2012 2
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2023 2
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COA3 overexpression promotes non-small cell lung cancer metastasis by reprogramming glucose metabolism.
Lin H, Gao Y, Sun K, Zhang Q, Li Y, Chen M, Jin F. Lin H, et al. Am J Cancer Res. 2022 Aug 15;12(8):3662-3678. eCollection 2022. Am J Cancer Res. 2022. PMID: 36119836 Free PMC article.
Silencing of COA3 significantly attenuated, while forced COA3 expression enhanced the migration and invasiveness of NSCLC cells. Mechanistically, we found that aerobic glycolysis, induced at least in part by dynamic-related protein 1 (DRP1) phosphorylation-mediated …
Silencing of COA3 significantly attenuated, while forced COA3 expression enhanced the migration and invasiveness of NSCLC cell …
Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria.
Mick DU, Vukotic M, Piechura H, Meyer HE, Warscheid B, Deckers M, Rehling P. Mick DU, et al. J Cell Biol. 2010 Oct 4;191(1):141-54. doi: 10.1083/jcb.201007026. Epub 2010 Sep 27. J Cell Biol. 2010. PMID: 20876281 Free PMC article.
Consequently, lack of Coa3 or Cox14 function traps Mss51 in the committed state and promotes Cox1 synthesis. Our data indicate that Coa1 binding to sequestered Mss51 in complex with Cox14, Coa3, and Cox1 is essential for full inactivation....
Consequently, lack of Coa3 or Cox14 function traps Mss51 in the committed state and promotes Cox1 synthesis. Our data indicate that C …
Human COA3 Is an Oligomeric Highly Flexible Protein in Solution.
Neira JL, Martínez-Rodríguez S, Hernández-Cifre JG, Cámara-Artigas A, Clemente P, Peralta S, Fernández-Moreno MÁ, Garesse R, García de la Torre J, Rizzuti B. Neira JL, et al. Biochemistry. 2016 Nov 15;55(45):6209-6220. doi: 10.1021/acs.biochem.6b00644. Epub 2016 Nov 4. Biochemistry. 2016. PMID: 27791355
Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature.
Ostergaard E, Weraarpachai W, Ravn K, Born AP, Jønson L, Duno M, Wibrand F, Shoubridge EA, Vissing J. Ostergaard E, et al. J Med Genet. 2015 Mar;52(3):203-7. doi: 10.1136/jmedgenet-2014-102914. Epub 2015 Jan 20. J Med Genet. 2015. PMID: 25604084
Whole exome sequencing identified compound heterozygous mutations (c.199dupC, c.215A>G) in COA3, a small inner membrane COX assembly factor, resulting in a pronounced decrease in the steady-state levels of COA3 protein. ...Immunoblot analysis showed that COX14 wa …
Whole exome sequencing identified compound heterozygous mutations (c.199dupC, c.215A>G) in COA3, a small inner membrane COX assemb …
Integrative genomics analysis highlights functionally relevant genes for equine behaviour.
Holtby AR, Hall TJ, McGivney BA, Han H, Murphy KJ, MacHugh DE, Katz LM, Hill EW. Holtby AR, et al. Anim Genet. 2023 Aug;54(4):457-469. doi: 10.1111/age.13320. Epub 2023 Mar 27. Anim Genet. 2023. PMID: 36971191

The SNPs of high significance (q < 0.01) were in proximity to genes (coping - GABARAP, NDM, OAZ1, RPS15A, SPARCL1, VAMP2; cortisol - CEBPA, COA3, DUSP1, HNRNPH1, RACK1) with biological functions in social behaviour, autism spectrum disorder, suicide, stress-induced anxi

…

The SNPs of high significance (q < 0.01) were in proximity to genes (coping - GABARAP, NDM, OAZ1, RPS15A, SPARCL1, VAMP2; cortisol - CEBP

…
Harvest-inducibility of the promoter of alfalfa S-adenosyl-L-methionine: trans-caffeoyl-CoA3-O-methyltransferase gene.
Zhang J, Erickson LR. Zhang J, et al. Mol Biol Rep. 2012 Mar;39(3):2489-95. doi: 10.1007/s11033-011-1000-2. Epub 2011 Jun 11. Mol Biol Rep. 2012. PMID: 21667113
The hi12 cDNA was identified as part of the S-adenosyl-L-methionine: trans-caffeoyl-CoA3-O-methyltransferase gene of alfalfa, a gene encoding an essential key enzyme in lignin synthesis. ...
The hi12 cDNA was identified as part of the S-adenosyl-L-methionine: trans-caffeoyl-CoA3-O-methyltransferase gene of alfalfa, a gene …
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
Meng F, Wu L, Dong L, Mitchell AV, James Block C, Liu J, Zhang H, Lu Q, Song WM, Zhang B, Chen W, Hu J, Wang J, Yang Q, Hüttemann M, Wu G. Meng F, et al. Nat Commun. 2019 Nov 6;10(1):5033. doi: 10.1038/s41467-019-13034-3. Nat Commun. 2019. PMID: 31695034 Free PMC article.
We further identify an interaction between EGFL9 and the cytochrome c oxidase (COX) assembly factor COA3. Consequently, EGFL9 regulates COX activity and modulates cell metabolism, promoting a Warburg-like metabolic phenotype. ...
We further identify an interaction between EGFL9 and the cytochrome c oxidase (COX) assembly factor COA3. Consequently, EGFL9 regulat …
A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis.
Bourens M, Barrientos A. Bourens M, et al. EMBO Rep. 2017 Mar;18(3):477-494. doi: 10.15252/embr.201643103. Epub 2017 Jan 12. EMBO Rep. 2017. PMID: 28082314 Free PMC article.
Here, we show that the intermembrane space twin CX(9)C protein CMC1 forms an early CIV assembly intermediate with COX1 and two assembly factors, the cardiomyopathy proteins COA3 and COX14. A TALEN-mediated CMC1 knockout HEK293T cell line displayed normal COX1 synthesis but …
Here, we show that the intermembrane space twin CX(9)C protein CMC1 forms an early CIV assembly intermediate with COX1 and two assembly fact …
Coagulase gene polymorphisms of Staphylococcus aureus isolates from patients at Kosti Teaching Hospital, Sudan.
Ibrahim OMA, Bilal NE, Azoz MEH, Eltahir HB. Ibrahim OMA, et al. Access Microbiol. 2019 May 15;1(3):e000026. doi: 10.1099/acmi.0.000026. eCollection 2019. Access Microbiol. 2019. PMID: 32974518 Free PMC article.
Most of the coa3 isolates (75.4%) were methicillin-resistant. CONCLUSION: Three polymorphic genotypes of S. aureus were identified in patients at Kosti Hospital. The coa3 genotype was the predominant one and was mostly detected in methicillin-resistant isolates....
Most of the coa3 isolates (75.4%) were methicillin-resistant. CONCLUSION: Three polymorphic genotypes of S. aureus were identified in …
Bi-allelic loss of function variants in COX20 gene cause autosomal recessive sensory neuronopathy.
Dong HL, Ma Y, Yu H, Wei Q, Li JQ, Liu GL, Li HF, Chen L, Chen DF, Bai G, Wu ZY. Dong HL, et al. Brain. 2021 Sep 4;144(8):2457-2470. doi: 10.1093/brain/awab135. Brain. 2021. PMID: 33751098
We speculated that the mechanism of COX20 was similar to other causative genes (e.g. SURF1, COX6A1, COA3 and SCO2) for peripheral neuropathies, all of which are functionally important in the structure and assembly of complex IV. ...
We speculated that the mechanism of COX20 was similar to other causative genes (e.g. SURF1, COX6A1, COA3 and SCO2) for peripheral neu …
25 results