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CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression.
Li Y, Shen X, Yang X, Lian F, Li Y, Li J, Huang Y, Shen W, Liu H. Li Y, et al. Front Genet. 2023 Aug 2;14:1240650. doi: 10.3389/fgene.2023.1240650. eCollection 2023. Front Genet. 2023. PMID: 37600654 Free PMC article. Review.
Here we summarized the genomic localization, protein structure and basic functions of CHDH and discuss the progress of CHDH research in metabolic disorders and other diseases. Moreover, we described the regulatory role of CHDH on the progression of different …
Here we summarized the genomic localization, protein structure and basic functions of CHDH and discuss the progress of CHDH re …
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Yao RQ, Ren C, Xia ZF, Yao YM. Yao RQ, et al. Autophagy. 2021 Feb;17(2):385-401. doi: 10.1080/15548627.2020.1725377. Epub 2020 Feb 12. Autophagy. 2021. PMID: 32048886 Free PMC article. Review.
In this review, we summarized the recent findings and mechanisms covering different kinds of organelle-specific autophagy, as well as their involvement in various diseases, aiming to arouse concern about the significance of the quality control of multiple organelles in the treatm …
In this review, we summarized the recent findings and mechanisms covering different kinds of organelle-specific autophagy, as well as their …
CHDH-PNPLA3 Gene-Gene Interactions Predict Insulin Resistance in Children with Obesity.
Chirita-Emandi A, Serban CL, Paul C, Andreescu N, Velea I, Mihailescu A, Serafim V, Tiugan DA, Tutac P, Zimbru C, Puiu M, Niculescu MD. Chirita-Emandi A, et al. Diabetes Metab Syndr Obes. 2020 Nov 19;13:4483-4494. doi: 10.2147/DMSO.S277268. eCollection 2020. Diabetes Metab Syndr Obes. 2020. PMID: 33239899 Free PMC article.
Out of 52 single nucleotide polymorphisms analysed, the interaction between genotypes CHDH(rs12676) and PNPLA3(rs738409) predicted insulin resistance. ...Plasma choline levels and alanine aminotransferase modulated the gene interaction effect, significantly improving the m …
Out of 52 single nucleotide polymorphisms analysed, the interaction between genotypes CHDH(rs12676) and PNPLA3(rs738409) predicted in …
Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.
Chang H, Li L, Peng T, Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, Nöthen MM, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M; Swedish Bipolar Study Group; MooDS Consortium; Xiao X, Li M. Chang H, et al. Mol Neurobiol. 2017 Sep;54(7):5166-5176. doi: 10.1007/s12035-016-0041-x. Epub 2016 Aug 25. Mol Neurobiol. 2017. PMID: 27562178
Follow-up genetic analyses of CHDH variants in multiple independent clinical datasets (including 11,564 cases and 17,686 controls) identified a risk SNP rs9836592 showing consistent associations with BPD (P (meta) = 5.72 10(-4)), and the risk allele indicated an increased …
Follow-up genetic analyses of CHDH variants in multiple independent clinical datasets (including 11,564 cases and 17,686 controls) id …
Polymorphisms in CHDH gene and the risk of tooth agenesis.
Mostowska A, Biedziak B, Dunin-Wilczynska I, Komorowska A, Jagodzinski PP. Mostowska A, et al. Birth Defects Res A Clin Mol Teratol. 2011 Mar;91(3):169-76. doi: 10.1002/bdra.20771. Epub 2011 Feb 9. Birth Defects Res A Clin Mol Teratol. 2011. PMID: 21308979
Moreover, the gene-gene interaction analysis revealed a significant epistatic interaction between CHDH (rs6445606) and PLD2 (rs3764897) in the susceptibility to hypodontia (p=0.004). CONCLUSION: Our study identified CHDH and PLD2 as novel candidate genes, the nucleo …
Moreover, the gene-gene interaction analysis revealed a significant epistatic interaction between CHDH (rs6445606) and PLD2 (rs376489 …
Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation.
McClatchie T, Meredith M, Ouédraogo MO, Slow S, Lever M, Mann MRW, Zeisel SH, Trasler JM, Baltz JM. McClatchie T, et al. J Biol Chem. 2017 Aug 18;292(33):13784-13794. doi: 10.1074/jbc.M117.803080. Epub 2017 Jun 29. J Biol Chem. 2017. PMID: 28663368 Free PMC article.
Chdh transcripts and CHDH protein were expressed in oocytes. No CHDH enzyme activity was detected in GV oocyte lysate, but CHDH became highly active during oocyte meiotic maturation. ...We then determined whether oocytes synthesized betaine and whether
Chdh transcripts and CHDH protein were expressed in oocytes. No CHDH enzyme activity was detected in GV oocyte lysate,
Deletion of murine choline dehydrogenase results in diminished sperm motility.
Johnson AR, Craciunescu CN, Guo Z, Teng YW, Thresher RJ, Blusztajn JK, Zeisel SH. Johnson AR, et al. FASEB J. 2010 Aug;24(8):2752-61. doi: 10.1096/fj.09-153718. Epub 2010 Apr 6. FASEB J. 2010. PMID: 20371614 Free PMC article.
We have previously identified single nucleotide polymorphisms (SNPs) in the human CHDH gene that, when present, seem to alter the activity of the CHDH enzyme. ...Chdh(+/+) and Chdh(-/-) mice produced comparable amounts of sperm; the impaired fertility …
We have previously identified single nucleotide polymorphisms (SNPs) in the human CHDH gene that, when present, seem to alter the act …
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Park S, Choi SG, Yoo SM, Son JH, Jung YK. Park S, et al. Autophagy. 2014;10(11):1906-20. doi: 10.4161/auto.32177. Epub 2014 Oct 30. Autophagy. 2014. PMID: 25483962 Free PMC article.
Conversely, overexpression of CHDH accelerates PARK2-mediated mitophagy. CHDH is found on both the outer and inner membranes of mitochondria in resting cells. ...Further, CHDH is crucial to the mitophagy induced by MPP+ in SN4741 cells. ...
Conversely, overexpression of CHDH accelerates PARK2-mediated mitophagy. CHDH is found on both the outer and inner membranes o …
Nutritional Genomics in Nonalcoholic Fatty Liver Disease.
Vasconcellos C, Ferreira O, Lopes MF, Ribeiro AF, Vasques J, Guerreiro CS. Vasconcellos C, et al. Biomedicines. 2023 Jan 23;11(2):319. doi: 10.3390/biomedicines11020319. Biomedicines. 2023. PMID: 36830856 Free PMC article. Review.
Different genetic polymorphisms seem to be involved in this context, including variants in PNPLA3, TM6SF2, PEMT, and CHDH genes, playing a role in the disease's susceptibility, development, and severity. ...
Different genetic polymorphisms seem to be involved in this context, including variants in PNPLA3, TM6SF2, PEMT, and CHDH genes, play …
The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.
Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DC. Wang Z, et al. Clin Cancer Res. 2007 Nov 1;13(21):6327-34. doi: 10.1158/1078-0432.CCR-07-0310. Clin Cancer Res. 2007. PMID: 17975144
PURPOSE: We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor (ER)-positive breast cancer patients receiving tamoxifen monotherapy. ...EXPERIMENTAL DESIGN: In a consecutive series of 148 ER-positive and …
PURPOSE: We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor …
64 results