Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 3
2010 1
2012 1
2013 1
2014 3
2015 22
2016 21
2017 18
2018 18
2019 21
2020 18
2021 11
2022 20
2023 18
2024 10

Text availability

Article attribute

Article type

Publication date

Search Results

162 results

Results by year

Filters applied: . Clear all
Page 1
Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models.
Kee TR, Espinoza Gonzalez P, Wehinger JL, Bukhari MZ, Ermekbaeva A, Sista A, Kotsiviras P, Liu T, Kang DE, Woo JA. Kee TR, et al. Front Aging Neurosci. 2021 Apr 22;13:660843. doi: 10.3389/fnagi.2021.660843. eCollection 2021. Front Aging Neurosci. 2021. PMID: 33967741 Free PMC article. Review.
CHCHD2 also regulates cell migration and differentiation, mitochondrial cristae structure, and apoptosis. In this review, we summarize the known disease-associated mutations of CHCHD2 in Asian and Caucasian populations, the physiological functions of CHCHD2,
CHCHD2 also regulates cell migration and differentiation, mitochondrial cristae structure, and apoptosis. In this review, we summariz
Increased CHCHD2 expression promotes liver fibrosis in nonalcoholic steatohepatitis via Notch/osteopontin signaling.
Li Y, Xiu W, Xu J, Chen X, Wang G, Duan J, Sun L, Liu B, Xie W, Pu G, Wang Q, Wang C. Li Y, et al. JCI Insight. 2022 Dec 8;7(23):e162402. doi: 10.1172/jci.insight.162402. JCI Insight. 2022. PMID: 36477358 Free PMC article.
The role of coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2) in NASH remains unknown. CHCHD2's functions as a transcription factor have received much less attention than those in mitochondria. ...In line with these findings, CHCHD2 deficiency …
The role of coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2) in NASH remains unknown. CHCHD2's functions as a …
CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy.
Shammas MK, Huang TH, Narendra DP. Shammas MK, et al. Biochem Soc Trans. 2023 Apr 26;51(2):797-809. doi: 10.1042/BST20221365. Biochem Soc Trans. 2023. PMID: 37021679 Review.
Modeling these disorders is revealing how mitochondrial dysfunction may drive ALS and PD pathogenesis by a gain of function mechanism, driven by protein misfolding of CHCHD2 and CHCHD10 into toxic species. It is also laying the groundwork for precision therapy of CHCHD2
Modeling these disorders is revealing how mitochondrial dysfunction may drive ALS and PD pathogenesis by a gain of function mechanism, drive …
Mitochondrial CHCHD2 and CHCHD10: Roles in Neurological Diseases and Therapeutic Implications.
Zhou W, Ma D, Tan EK. Zhou W, et al. Neuroscientist. 2020 Apr;26(2):170-184. doi: 10.1177/1073858419871214. Epub 2019 Sep 16. Neuroscientist. 2020. PMID: 31526091 Review.
Functionally, CHCHD2 and CHCHD10 have been demonstrated to interact with each other in mitochondria. ...Multiple experimental models suggest that CHCHD2 maintains mitochondrial cristae and disease-associated CHCHD2 mutations function in a loss-of-function man …
Functionally, CHCHD2 and CHCHD10 have been demonstrated to interact with each other in mitochondria. ...Multiple experimental models …
CHCHD2 and CHCHD10: Future therapeutic targets in cognitive disorder and motor neuron disorder.
Jiang T, Wang Y, Wang X, Xu J. Jiang T, et al. Front Neurosci. 2022 Aug 18;16:988265. doi: 10.3389/fnins.2022.988265. eCollection 2022. Front Neurosci. 2022. PMID: 36061599 Free PMC article. Review.
CHCHD2 and CHCHD10 are homolog mitochondrial proteins that play key roles in the neurological, cardiovascular, and reproductive systems. ...This review focuses on the functions of CHCHD2 and/or CHCHD10. This review reveals protective effects and mechanisms of CHC
CHCHD2 and CHCHD10 are homolog mitochondrial proteins that play key roles in the neurological, cardiovascular, and reproductive syste
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q. Ruan Y, et al. Cell Death Dis. 2022 Feb 16;13(2):156. doi: 10.1038/s41419-022-04602-5. Cell Death Dis. 2022. PMID: 35173147 Free PMC article.
Further, during mitochondria stress-induced by carbonyl cyanide m-chlorophenylhydrazone (CCCP) treatment, CHCHD2 and CHCHD10 translocate to the cytosol and interacte with eIF2a, which attenuates mtISR overactivation by suppressing eIF2a phosphorylation and its downstream r …
Further, during mitochondria stress-induced by carbonyl cyanide m-chlorophenylhydrazone (CCCP) treatment, CHCHD2 and CHCHD10 transloc …
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion and therapeutic resistance.
Lumibao JC, Haak PL, Kolossov VL, Chen JE, Stutchman J, Ruiz A, Sivaguru M, Sarkaria JN, Harley BAC, Steelman AJ, Gaskins HR. Lumibao JC, et al. Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1. Int J Oncol. 2023. PMID: 37654190 Free PMC article.
CHCHD2 was distributed in both the mitochondria and nuclei of U87 and U87vIII cells, and the U87vIII cells exhibited a greater nuclear expression of CHCHD2 compared to isogenic U87 cells. Incubation under hypoxic conditions, serum starvation and the reductive unfold
CHCHD2 was distributed in both the mitochondria and nuclei of U87 and U87vIII cells, and the U87vIII cells exhibited a greater nuclea
Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10-what distinguishes the two?
Ikeda A, Imai Y, Hattori N. Ikeda A, et al. Front Cell Dev Biol. 2022 Sep 9;10:996061. doi: 10.3389/fcell.2022.996061. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36158221 Free PMC article. Review.
Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) are mitochondrial proteins that are thought to be genes which duplicated during evolution and are the causative genes for Parkinson's dis …
Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD1 …
Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1.
Liu W, Duan X, Xu L, Shang W, Zhao J, Wang L, Li JC, Chen CH, Liu JP, Tong C. Liu W, et al. Cell Death Differ. 2020 Jun;27(6):2014-2029. doi: 10.1038/s41418-019-0482-7. Epub 2020 Jan 6. Cell Death Differ. 2020. PMID: 31907391 Free PMC article.
Overexpression of Chchd2 carrying human disease-related point mutations failed to fully rescue the mitochondrial defects in Chchd2 mutants. ...The expression level of Opa1 was reduced in Chchd2 mutants and increased when Chchd2 was overexpressed. The c …
Overexpression of Chchd2 carrying human disease-related point mutations failed to fully rescue the mitochondrial defects in Chchd2
CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and neuropathological features of Parkinson's disease.
Fan L, Zhang S, Li X, Hu Z, Yang J, Zhang S, Zheng H, Su Y, Luo H, Liu X, Fan Y, Sun H, Zhang Z, Miao J, Song B, Xia Z, Shi C, Mao C, Xu Y. Fan L, et al. Brain Pathol. 2023 May;33(3):e13124. doi: 10.1111/bpa.13124. Epub 2022 Nov 2. Brain Pathol. 2023. PMID: 36322611 Free PMC article.
The p.Thr61Ile (p.T61I) mutation in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) was deemed a causative factor in Parkinson's disease (PD). However, the pathomechanism of the CHCHD2 p.T61I mutation in PD remains unclear. Few existing mouse models …
The p.Thr61Ile (p.T61I) mutation in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) was deemed a causative factor in …
162 results