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LncRNA CALML3-AS1 modulated by m(6)A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression.
Zhang H, Wang SQ, Zhu JB, Wang LN, Lin H, Li LF, Cheng YD, Duan CJ, Zhang CF. Zhang H, et al. Cancer Gene Ther. 2023 Dec;30(12):1649-1662. doi: 10.1038/s41417-023-00670-7. Epub 2023 Oct 27. Cancer Gene Ther. 2023. PMID: 37884580
Non-small cell lung cancer (NSCLC) is a common and lethal malignancy. The carcinogenic roles of lncRNA CALML3 antisense RNA 1 (CALML3-AS1) have been documented. However, the function and potential mechanisms of CALML3-AS1 in the progression of NSCLC need to b …
Non-small cell lung cancer (NSCLC) is a common and lethal malignancy. The carcinogenic roles of lncRNA CALML3 antisense RNA 1 (CAL …
LncRNA CALML3-AS1 regulates chondrocyte apoptosis by acting as a sponge for miR-146a.
Nie T, Zhang C, Zhang G, Fang L, Liu X, Li R, Cui L, Wang J. Nie T, et al. Autoimmunity. 2021 Sep;54(6):336-342. doi: 10.1080/08916934.2021.1943663. Epub 2021 Jul 20. Autoimmunity. 2021. PMID: 34282692
Our bioinformatics analysis showed that miR-146a may bind with long non-coding RNA (lncRNA) CALML3 antisense RNA 1 (CALML3-AS1). Our study was therefore carried out to investigate the interactions between lncRNA CALML3-AS1 and miR-146a in osteoarthritis. ...M …
Our bioinformatics analysis showed that miR-146a may bind with long non-coding RNA (lncRNA) CALML3 antisense RNA 1 (CALML3-AS1 …
OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis.
Chang W, Luo Q, Wu X, Nan Y, Zhao P, Zhang L, Luo A, Jiao W, Zhu Q, Fu Y, Liu Z. Chang W, et al. Cell Rep. 2022 Oct 25;41(4):111561. doi: 10.1016/j.celrep.2022.111561. Cell Rep. 2022. PMID: 36288705 Free article.
Mechanistically, OTUB2 promotes the deubiquitination and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and subsequently regulates the transcription of calmodulin-like protein 3 (CALML3). Activation of CALML3-mediated mitochondrial cal …
Mechanistically, OTUB2 promotes the deubiquitination and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and s …
Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.
Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, Xia J. Yang B, et al. Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2. Nat Commun. 2018. PMID: 29445139 Free PMC article.
We also reveal the biological role of CALML3 in metastasis initiation at a network level, including proximal regulation and cascading influences in dysfunctional pathways. Our further experiments and clinical samples show that DNB with CALML3 reduced pulmonary metas …
We also reveal the biological role of CALML3 in metastasis initiation at a network level, including proximal regulation and cascading …
LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR-20a-5p/RBM38 axis.
Zhang X, Zhang X, Jia Q, Li H, Ma R, Yang G, Yin F, Jiang N, Yin D. Zhang X, et al. BMC Cancer. 2022 Mar 29;22(1):344. doi: 10.1186/s12885-022-09360-3. BMC Cancer. 2022. PMID: 35351042 Free PMC article.
It is imperative to have a better understanding of the molecular mechanisms underlying TC development and identify novel therapeutic targets. This study characterized the role of lncRNA CALML3-AS1 (CALML3-AS1) in the development of papillary thyroid cancer (PTC). .. …
It is imperative to have a better understanding of the molecular mechanisms underlying TC development and identify novel therapeutic targets …
LncRNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316.
Wang F, Zu Y, Huang W, Chen H, Xie H, Yang Y. Wang F, et al. Biochem Biophys Res Commun. 2018 Sep 26;504(1):171-176. doi: 10.1016/j.bbrc.2018.08.150. Epub 2018 Sep 1. Biochem Biophys Res Commun. 2018. PMID: 30177388
LncRNAs are also closely associated with bladder cancer (BCa) progression. In the present study, we screened out a novel lncRNA CALML3-AS1 with increased expression value in BCa tissues. Particularly, we showed that CALML3-AS1 overexpression correlates with advanced …
LncRNAs are also closely associated with bladder cancer (BCa) progression. In the present study, we screened out a novel lncRNA CALML3 …
Upregulation of lncRNA CALML3-AS1 promotes cell proliferation and metastasis in cervical cancer via activation of the Wnt/beta-catenin pathway.
Liu CN, Zhang HY, Liu CL, Wang CC. Liu CN, et al. Eur Rev Med Pharmacol Sci. 2019 Jul;23(13):5611-5620. doi: 10.26355/eurrev_201907_18295. Eur Rev Med Pharmacol Sci. 2019. PMID: 31298313 Free article.
OBJECTIVE: It is well verified that lncRNA are emerging as imperative regulators in various tumors. LncRNA CALML3-AS1 (CALML3-AS1), a freshly discovered lncRNA, has been confirmed as a tumor promoter in bladder cancer. ...The functions of CALML3-AS1 on cell p …
OBJECTIVE: It is well verified that lncRNA are emerging as imperative regulators in various tumors. LncRNA CALML3-AS1 (CALML3- …
UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2 and ERK1/2 pathways in cataract.
Jia Y, Qin Q, Fang CP, Shen W, Sun TT, Huang YL, Li WJ, Deng AM. Jia Y, et al. Int J Mol Med. 2018 May;41(5):3041-3050. doi: 10.3892/ijmm.2018.3478. Epub 2018 Feb 9. Int J Mol Med. 2018. PMID: 29436594
Notably, silencing of CALML3 had similar effects to UVB irradiation and inhibited the activation JNK1/2 and ERK1/2 pathways. Nimodipine, a Ca2+-channel antagonist, significantly attenuated the damages induced by CALML3 downregulation. In conclusion, UVB irradiation …
Notably, silencing of CALML3 had similar effects to UVB irradiation and inhibited the activation JNK1/2 and ERK1/2 pathways. Nimodipi …
Immunolocalization of the tumor-sensitive calmodulin-like protein CALML3 in normal human skin and hyperproliferative skin disorders.
Bennett RD, Pittelkow MR, Strehler EE. Bennett RD, et al. PLoS One. 2013 Apr 18;8(4):e62347. doi: 10.1371/journal.pone.0062347. Print 2013. PLoS One. 2013. PMID: 23638045 Free PMC article.
CALML3 nuclear localization was inversely correlated to Ki-67 staining in each disease, indicating that CALML3 nuclear presence is related to terminal cell differentiation and postmitotic state. ...This suggests that CALML3 is a useful marker for normal and b …
CALML3 nuclear localization was inversely correlated to Ki-67 staining in each disease, indicating that CALML3 nuclear presenc …
Human Calmodulin-Like Protein CALML3: A Novel Marker for Normal Oral Squamous Mucosa That Is Downregulated in Malignant Transformation.
Brooks MD, Bennett RD, Weaver AL, Sebo TJ, Eckert SE, Strehler EE, Carr AB. Brooks MD, et al. Int J Dent. 2013;2013:592843. doi: 10.1155/2013/592843. Epub 2013 Jul 8. Int J Dent. 2013. PMID: 23935623 Free PMC article.
Immunohistochemical analysis using an affinity-purified CALML3 antibody was performed on biopsy-confirmed oral tissue samples representing these phases. ...CALML3 may thus be a sensitive new marker for oral cancer screening....
Immunohistochemical analysis using an affinity-purified CALML3 antibody was performed on biopsy-confirmed oral tissue samples represe …
43 results