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Page 1
β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer.
Suzuki T, Kilbey A, Casa-Rodríguez N, Lawlor A, Georgakopoulou A, Hayman H, Yin Swe KL, Nordin A, Cantù C, Vantourout P, Ridgway RA, Byrne RM, Chen L, Verzi MP, Gay DM, Gil Vázquez E, Belnoue-Davis HL, Gilroy K, Køstner AH, Kersten C, Thuwajit C, Andersen DK, Wiesheu R, Jandke A, Blyth K, Roseweir AK, Leedham SJ, Dunne PD, Edwards J, Hayday A, Sansom OJ, Coffelt SB. Suzuki T, et al. Cancer Immunol Res. 2023 Aug 3;11(8):1137-1155. doi: 10.1158/2326-6066.CIR-22-0644. Cancer Immunol Res. 2023. PMID: 37309673 Free PMC article.
We then demonstrated that beta-catenin activation through loss of Apc rapidly suppressed expression of the mRNA encoding the HNF4A and HNF4G transcription factors, preventing their binding to promoter regions of Btnl genes. Reexpression of BTNL1 and BTNL6 in cancer cells i …
We then demonstrated that beta-catenin activation through loss of Apc rapidly suppressed expression of the mRNA encoding the HNF4A and HNF4G …
Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability.
Guo H, Zhang J, Jiang Z, Zhu X, Yang J, Mu R, Du Y, Tian Y, Zhu P, Fan Z. Guo H, et al. EMBO J. 2023 Mar 15;42(6):e112039. doi: 10.15252/embj.2022112039. Epub 2023 Jan 30. EMBO J. 2023. PMID: 36715460 Free PMC article.
Loss of circBtnl1 in mice enhanced ISC self-renewal capacity and epithelial regeneration, without changes in mRNA and protein levels of its parental gene Btnl1. Mechanistically, circBtnl1 and Atf4 mRNA competitively bound the ATP-dependent RNA helicase Ddx3y to impair the …
Loss of circBtnl1 in mice enhanced ISC self-renewal capacity and epithelial regeneration, without changes in mRNA and protein levels of its …
The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.
Lebrero-Fernández C, Bas-Forsberg A. Lebrero-Fernández C, et al. Sci Rep. 2016 Aug 16;6:31524. doi: 10.1038/srep31524. Sci Rep. 2016. PMID: 27528202 Free PMC article.
Murine Butyrophilin-like (Btnl) 1 and Btnl6 are primarily restricted to intestinal epithelium where they regulate the function of intraepithelial T lymphocytes. We recently demonstrated that Btnl1 and Btnl6 can form an intra-family heterocomplex and that the Btnl1-B …
Murine Butyrophilin-like (Btnl) 1 and Btnl6 are primarily restricted to intestinal epithelium where they regulate the function of intraepith …
A butyrophilin family member critically inhibits T cell activation.
Yamazaki T, Goya I, Graf D, Craig S, Martin-Orozco N, Dong C. Yamazaki T, et al. J Immunol. 2010 Nov 15;185(10):5907-14. doi: 10.4049/jimmunol.1000835. Epub 2010 Oct 13. J Immunol. 2010. PMID: 20944003
The putative receptor for BTNL1 was found on activated T cells and APCs. Also, recombinant BTNL1 molecule inhibited T cell proliferation by arresting cell cycle progression. ...Therefore, BTNL1 is a critical inhibitory molecule for T cell activation and immun …
The putative receptor for BTNL1 was found on activated T cells and APCs. Also, recombinant BTNL1 molecule inhibited T cell pro …
New Insights Into the Regulation of γδ T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity.
Blazquez JL, Benyamine A, Pasero C, Olive D. Blazquez JL, et al. Front Immunol. 2018 Jul 11;9:1601. doi: 10.3389/fimmu.2018.01601. eCollection 2018. Front Immunol. 2018. PMID: 30050536 Free PMC article. Review.
As long as the field develops exponentially, new relationships between certain gammadelta T cell subsets, on one hand, and their BTN/BTNL counterparts mainly present on epithelial and tumor cells, on the other, are described in the scientific literature. Btnl1/Btnl6 in mic …
As long as the field develops exponentially, new relationships between certain gammadelta T cell subsets, on one hand, and their BTN/BTNL co …
Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.
Vantourout P, Laing A, Woodward MJ, Zlatareva I, Apolonia L, Jones AW, Snijders AP, Malim MH, Hayday AC. Vantourout P, et al. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1039-1044. doi: 10.1073/pnas.1701237115. Epub 2018 Jan 16. Proc Natl Acad Sci U S A. 2018. PMID: 29339503 Free PMC article.
In particular, murine and human gut gammadelta cell regulation depends on pairings of Btnl1 and Btnl6 and BTNL3 and BTNL8, respectively, whereas blood gammadelta cells are reported to be regulated by BTN3A1 independent of other BTNs. Addressing this paradox, we show that B …
In particular, murine and human gut gammadelta cell regulation depends on pairings of Btnl1 and Btnl6 and BTNL3 and BTNL8, respective …
Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.
Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML, Laing A, Spencer-Dene B, East P, Gibbons D, Irving PM, Pereira P, Steinhoff U, Hayday A. Di Marco Barros R, et al. Cell. 2016 Sep 22;167(1):203-218.e17. doi: 10.1016/j.cell.2016.08.030. Epub 2016 Sep 15. Cell. 2016. PMID: 27641500 Free PMC article.
However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 expressed by murine enterocytes is shown to shape the local TCR-Vgamma7(+) gammadelta compartment. Uninfluenced by microbial or food anti …
However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 …
Murine Butyrophilin-Like 1 and Btnl6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes.
Lebrero-Fernández C, Bergström JH, Pelaseyed T, Bas-Forsberg A. Lebrero-Fernández C, et al. Front Immunol. 2016 Jan 19;7:1. doi: 10.3389/fimmu.2016.00001. eCollection 2016. Front Immunol. 2016. PMID: 26834743 Free PMC article.
Although Btnl1 can exist in a cell surface-expressed homomeric form, we found that it additionally forms heteromeric complexes with Btnl6, and that the engagement of Btnl1 is a prerequisite for surface expression of Btnl6 on intestinal epithelial cells. ...The effec …
Although Btnl1 can exist in a cell surface-expressed homomeric form, we found that it additionally forms heteromeric complexes with B …
Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.
Bas A, Swamy M, Abeler-Dörner L, Williams G, Pang DJ, Barbee SD, Hayday AC. Bas A, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4376-81. doi: 10.1073/pnas.1010647108. Epub 2011 Feb 28. Proc Natl Acad Sci U S A. 2011. PMID: 21368163 Free PMC article.
Btnl1 protein is mostly cytoplasmic, but surface expression can be induced, and in vivo Btnl1 can be detected adjacent to the IEL. In a newly developed culture system, enforced epithelial cell expression of Btnl1 attenuated the cells' response to activated IE …
Btnl1 protein is mostly cytoplasmic, but surface expression can be induced, and in vivo Btnl1 can be detected adjacent to the …
Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer.
Lebrero-Fernández C, Wenzel UA, Akeus P, Wang Y, Strid H, Simrén M, Gustavsson B, Börjesson LG, Cardell SL, Öhman L, Quiding-Järbrink M, Bas-Forsberg A. Lebrero-Fernández C, et al. Immun Inflamm Dis. 2016 Apr 1;4(2):191-200. doi: 10.1002/iid3.105. eCollection 2016 Jun. Immun Inflamm Dis. 2016. PMID: 27957327 Free PMC article.
Colonic inflammation in Muc2(-/-) mice significantly down-regulated the expression of particularly Btnl1, Btnl4, and Btnl6 mRNA, and intestinal polyps derived from Apc(Min/+) mice displayed altered levels of Btn1a1, Btn2a2, and Btnl1 transcripts. ...
Colonic inflammation in Muc2(-/-) mice significantly down-regulated the expression of particularly Btnl1, Btnl4, and Btnl6 mRNA, and …
12 results