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Page 1
Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription.
Pereira LA, Klejman MP, Timmers HT. Pereira LA, et al. Gene. 2003 Oct 2;315:1-13. doi: 10.1016/s0378-1119(03)00714-5. Gene. 2003. PMID: 14557059 Review.
Genetic identification of Mot1p as a repressor of pol II transcription was supported by findings that Mot1p and BTAF1 could dissociate TBP from TATA DNA complexes using the energy of ATP hydrolysis. ...We review these data in the context of previous findings with particula …
Genetic identification of Mot1p as a repressor of pol II transcription was supported by findings that Mot1p and BTAF1 could dissociat …
Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants.
Klejman MP, Zhao X, van Schaik FM, Herr W, Timmers HT. Klejman MP, et al. Nucleic Acids Res. 2005 Sep 22;33(17):5426-36. doi: 10.1093/nar/gki850. Print 2005. Nucleic Acids Res. 2005. PMID: 16179647 Free PMC article.
Here, we present an extensive mapping study of TBP residues involved in BTAF1 interaction. This shows that residues in the concave, DNA-binding surface of TBP are important for BTAF1 binding. In addition, BTAF1 interacts with residues in helix 2 on the convex …
Here, we present an extensive mapping study of TBP residues involved in BTAF1 interaction. This shows that residues in the concave, D …
NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.
Klejman MP, Pereira LA, van Zeeburg HJ, Gilfillan S, Meisterernst M, Timmers HT. Klejman MP, et al. Mol Cell Biol. 2004 Nov;24(22):10072-82. doi: 10.1128/MCB.24.22.10072-10082.2004. Mol Cell Biol. 2004. PMID: 15509807 Free PMC article.
Here, we present evidence that the NC2alpha subunit interacts with BTAF1. In contrast, the NC2beta subunit is not able to associate with BTAF1 and seems to interfere with the BTAF1-TBP interaction. Addition of NC2alpha or the NC2 complex can stimulate the abi …
Here, we present evidence that the NC2alpha subunit interacts with BTAF1. In contrast, the NC2beta subunit is not able to associate w …
Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila.
Yagi Y, Ip YT. Yagi Y, et al. EMBO Rep. 2005 Nov;6(11):1088-94. doi: 10.1038/sj.embor.7400542. Epub 2005 Sep 30. EMBO Rep. 2005. PMID: 16200050 Free PMC article.
We have identified a novel component, Helicase89B, that is required for the inducible antimicrobial response in Drosophila larvae by means of a P-element insertional genetic screen. Helicase89B belongs to the Mot1p/BTAF1 subfamily of SNF2-like ATPases. This subfamily can i …
We have identified a novel component, Helicase89B, that is required for the inducible antimicrobial response in Drosophila larvae by means o …
An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.
Wansleeben C, van Gurp L, de Graaf P, Mousson F, Marc Timmers HT, Meijlink F. Wansleeben C, et al. Mech Dev. 2011 May-Jun;128(5-6):279-88. doi: 10.1016/j.mod.2011.03.002. Epub 2011 Mar 16. Mech Dev. 2011. PMID: 21419221 Free article.
The mouse Btaf1 gene, an ortholog of yeast MOT1, encodes a highly conserved general transcription factor. ...Here we report the isolation of a mouse line carrying a Btaf1 allele containing an ENU-induced point mutation that causes a substitution mutation in the B …
The mouse Btaf1 gene, an ortholog of yeast MOT1, encodes a highly conserved general transcription factor. ...Here we report the isola …
The general transcription machinery and general cofactors.
Thomas MC, Chiang CM. Thomas MC, et al. Crit Rev Biochem Mol Biol. 2006 May-Jun;41(3):105-78. doi: 10.1080/10409230600648736. Crit Rev Biochem Mol Biol. 2006. PMID: 16858867 Review.
Three classes of general cofactors, including TBP-associated factors (TAFs), Mediator, and upstream stimulatory activity (USA)-derived positive cofactors (PC1/PARP-1, PC2, PC3/DNA topoisomerase I, and PC4) and negative cofactor 1 (NC1/HMGB1), normally function independently or in …
Three classes of general cofactors, including TBP-associated factors (TAFs), Mediator, and upstream stimulatory activity (USA)-derived posit …
Integrated bioinformatics and validation to construct lncRNA-miRNA-mRNA ceRNA network in status epilepticus.
Lin Y, Wen H, Yang B, Wang C, Liang R. Lin Y, et al. Heliyon. 2023 Nov 10;9(11):e22205. doi: 10.1016/j.heliyon.2023.e22205. eCollection 2023 Nov. Heliyon. 2023. PMID: 38074882 Free PMC article.
The constructed ceRNA network-1 contained 7 up-regulated DE-mRNAs (Arid5a, Adm, Insig1, Midn, Btaf1, Per1, Slc25a25), 1 down-regulated DE-miRNA (mmu-miR-6413), and 1 up-regulated DE-lncRNA (Zmiz1os1). ...
The constructed ceRNA network-1 contained 7 up-regulated DE-mRNAs (Arid5a, Adm, Insig1, Midn, Btaf1, Per1, Slc25a25), 1 down-regulate …
Chromatin interaction of TATA-binding protein is dynamically regulated in human cells.
de Graaf P, Mousson F, Geverts B, Scheer E, Tora L, Houtsmuller AB, Timmers HT. de Graaf P, et al. J Cell Sci. 2010 Aug 1;123(Pt 15):2663-71. doi: 10.1242/jcs.064097. Epub 2010 Jul 13. J Cell Sci. 2010. PMID: 20627952
TBP dynamics are regulated by the joint action of the SNF2-related BTAF1 protein and the NC2 complex. Strikingly, both BTAF1 and NC2 predominantly affect TBP dissociation rates, leaving the association rate unchanged. ...Our results support a model for a BTAF1 …
TBP dynamics are regulated by the joint action of the SNF2-related BTAF1 protein and the NC2 complex. Strikingly, both BTAF1 a …
Molecular architecture of the basal transcription factor B-TFIID.
Pereira LA, Klejman MP, Ruhlmann C, Kavelaars F, Oulad-Abdelghani M, Timmers HT, Schultz P. Pereira LA, et al. J Biol Chem. 2004 May 21;279(21):21802-7. doi: 10.1074/jbc.M313519200. Epub 2004 Feb 26. J Biol Chem. 2004. PMID: 14988402 Free article.
BTAF1 has been proposed to play a key role in the dynamic regulation of TBP function in RNA polymerase II transcription. ...The central portion of BTAF1 localizes to the base of the thumb. Comparison of the native B-TFIID with its recombinant form shows that both sh …
BTAF1 has been proposed to play a key role in the dynamic regulation of TBP function in RNA polymerase II transcription. ...The centr …
miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.
Hewitson JP, Shah KM, Brown N, Grevitt P, Hain S, Newling K, Sharp TV, Kaye PM, Lagos D. Hewitson JP, et al. EMBO Rep. 2019 Apr;20(4):e46620. doi: 10.15252/embr.201846620. Epub 2019 Mar 4. EMBO Rep. 2019. PMID: 30833344 Free PMC article.
The transcriptomic hallmark of splenic CD4(+) T cells lacking the miR-132/212 cluster during chronic infection is an increase in mRNA levels of ribosomal protein (RP) genes. BTAF1, a co-factor of B-TFIID and novel miR-132/212-3p target, and p300 contribute towards miR-132/ …
The transcriptomic hallmark of splenic CD4(+) T cells lacking the miR-132/212 cluster during chronic infection is an increase in mRNA levels …
28 results