Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease.
Koide T, Mandai S, Kitaoka R, Matsuki H, Chiga M, Yamamoto K, Yoshioka K, Yagi Y, Suzuki S, Fujiki T, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Rai T, Yokota T, Uchida S.
Koide T, et al.
Circ Res. 2023 Feb 17;132(4):415-431. doi: 10.1161/CIRCRESAHA.122.321939. Epub 2023 Jan 26.
Circ Res. 2023.
PMID: 36700539
Free article.
Cultures of A10 embryonic rat VSMCs showed increased calcification and transcription of osterix (Sp7), osteocalcin (Bglap), and osteopontin (Spp1) when treated with rat CKD serum. sEVs, but not sEV-depleted serum, accelerated calcification in VSMCs. ...
Cultures of A10 embryonic rat VSMCs showed increased calcification and transcription of osterix (Sp7), osteocalcin (Bglap), and osteo …