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Year Number of Results
2010 2
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2014 1
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2023 1
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ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.
Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. Katsurahara K, et al. Cancer Sci. 2021 Mar;112(3):1026-1037. doi: 10.1111/cas.14796. Epub 2021 Jan 22. Cancer Sci. 2021. PMID: 33404124 Free PMC article.
The function of ANO9 in gastrointestinal cancer remains unclear. We investigated the biological behaviors and clinical prognostic values of ANO9 in gastric cancer (GC). ...IHC revealed a correlation between the expression of ANO9 and PD-L2 and also that the s …
The function of ANO9 in gastrointestinal cancer remains unclear. We investigated the biological behaviors and clinical prognostic val …
ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma.
Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E. Katsurahara K, et al. Ann Surg Oncol. 2020 Sep;27(9):3218-3230. doi: 10.1245/s10434-020-08368-y. Epub 2020 Mar 29. Ann Surg Oncol. 2020. PMID: 32227267
BACKGROUND: Few studies have reported the function and activation mechanism of ANO9 in esophageal squamous cell carcinoma (ESCC). The current study aimed to investigate the role of ANO9 in the regulation of tumor progression. ...In the cell cycle analysis, depletion …
BACKGROUND: Few studies have reported the function and activation mechanism of ANO9 in esophageal squamous cell carcinoma (ESCC). The …
ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer.
Jun I, Park HS, Piao H, Han JW, An MJ, Yun BG, Zhang X, Cha YH, Shin YK, Yook JI, Jung J, Gee HY, Park JS, Yoon DS, Jeung HC, Lee MG. Jun I, et al. Br J Cancer. 2017 Dec 5;117(12):1798-1809. doi: 10.1038/bjc.2017.355. Epub 2017 Oct 12. Br J Cancer. 2017. PMID: 29024940 Free PMC article.
Mechanistic analysis suggested that physical association of ANO9 with epidermal growth factor receptor (EGFR) underlies ANO9-induced cell proliferation. ...In addition, high ANO9 expression is a poor prognostic factor in patients with pancreatic cancer. ...
Mechanistic analysis suggested that physical association of ANO9 with epidermal growth factor receptor (EGFR) underlies ANO9-i …
Identification and characterization of ANO9 in stage II and III colorectal carcinoma.
Li C, Cai S, Wang X, Jiang Z. Li C, et al. Oncotarget. 2015 Oct 6;6(30):29324-34. doi: 10.18632/oncotarget.4979. Oncotarget. 2015. PMID: 26317553 Free PMC article.
BACKGROUND AND OBJECTIVES: The precise role and potential underlying mechanisms of anoctamin 9 (ANO9) remain largely unknown. This study aims to characterize the role and oncogenic mechanisms of ANO9 in stage II and III colorectal cancer (CRC). ...Decreased expressi …
BACKGROUND AND OBJECTIVES: The precise role and potential underlying mechanisms of anoctamin 9 (ANO9) remain largely unknown. This st …
Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal.
Kim H, Kim H, Lee J, Lee B, Kim HR, Jung J, Lee MO, Oh U. Kim H, et al. Cell Calcium. 2018 May;71:75-85. doi: 10.1016/j.ceca.2017.12.003. Epub 2017 Dec 30. Cell Calcium. 2018. PMID: 29604966
The cAMP-induced ANO9 currents were permeable to cations. The cAMP-dependent ANO9 currents were augmented by intracellular Ca(2+). Ano9 transcripts were predominant in the intestines. Human intestinal SW480 cells expressed high levels of Ano9 transcrip …
The cAMP-induced ANO9 currents were permeable to cations. The cAMP-dependent ANO9 currents were augmented by intracellular Ca( …
Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function.
Leitzke S, Seidel J, Ahrens B, Schreiber R, Kunzelmann K, Sperrhacke M, Bhakdi S, Reiss K. Leitzke S, et al. Membranes (Basel). 2022 Jan 20;12(2):123. doi: 10.3390/membranes12020123. Membranes (Basel). 2022. PMID: 35207044 Free PMC article.
Inhibitor experiments indicated that ANO4/ANO9-mediated enhancement of TGFalpha-cleavage broadened the spectrum of participating metalloproteinases. Annexin V-staining demonstrated increased externalisation of PS in ANO4/ANO9-overexpressing cells. Competition experi …
Inhibitor experiments indicated that ANO4/ANO9-mediated enhancement of TGFalpha-cleavage broadened the spectrum of participating meta …
Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.
Kim H, Kim H, Nguyen LT, Ha T, Lim S, Kim K, Kim SH, Han K, Hyeon SJ, Ryu H, Park YS, Kim SH, Kim IB, Hong GS, Lee SE, Choi Y, Cohen LB, Oh U. Kim H, et al. Prog Neurobiol. 2022 Dec;219:102369. doi: 10.1016/j.pneurobio.2022.102369. Epub 2022 Oct 28. Prog Neurobiol. 2022. PMID: 36330924
In line with the difference in olfaction between birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick CNGA2, a major transduction channel, showed greater responses to cAMP. Thus, we concluded that the signal amplification by ANO9 is i …
In line with the difference in olfaction between birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick …
Contribution of Anoctamins to Cell Survival and Cell Death.
Kunzelmann K, Ousingsawat J, Benedetto R, Cabrita I, Schreiber R. Kunzelmann K, et al. Cancers (Basel). 2019 Mar 19;11(3):382. doi: 10.3390/cancers11030382. Cancers (Basel). 2019. PMID: 30893776 Free PMC article. Review.
Meanwhile, ANO1 has been examined in more detail, and the role of ANO1 in cell proliferation and the development of different types of malignomas is now well established. While ANO5, ANO7, and ANO9 may also be relevant for growth of cancers, evidence has been provided for …
Meanwhile, ANO1 has been examined in more detail, and the role of ANO1 in cell proliferation and the development of different types of malig …
TMEM16 proteins: unknown structure and confusing functions.
Picollo A, Malvezzi M, Accardi A. Picollo A, et al. J Mol Biol. 2015 Jan 16;427(1):94-105. doi: 10.1016/j.jmb.2014.09.028. Epub 2014 Oct 17. J Mol Biol. 2015. PMID: 25451786 Free PMC article. Review.
The roles of other family members, such as TMEM16C (ANO3), TMEM16D (ANO4), TMEM16F (ANO6), TMEM16G (ANO7) and TMEM16J (ANO9), remain poorly understood and controversial. These homologues were reported to be phospholipid scramblases, ion channels, to have both functions or …
The roles of other family members, such as TMEM16C (ANO3), TMEM16D (ANO4), TMEM16F (ANO6), TMEM16G (ANO7) and TMEM16J (ANO9), remain …
24 results