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2013 5
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93 results

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MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Hu L, Xie X, Xue H, Wang T, Panayi AC, Lin Z, Xiong Y, Cao F, Yan C, Chen L, Cheng P, Zha K, Sun Y, Liu G, Yu C, Hu Y, Tao R, Zhou W, Mi B, Liu G. Hu L, et al. Exp Mol Med. 2022 Jul;54(7):961-972. doi: 10.1038/s12276-022-00799-9. Epub 2022 Jul 13. Exp Mol Med. 2022. PMID: 35831436 Free PMC article.
Moreover, in vitro, overexpression of miR-1224-5p slowed Rankl-induced osteoclast differentiation and promoted osteoblast differentiation via the Rap1-signaling pathway by targeting ADCY2. In addition, in vivo overexpression of miR-1224-5p significantly promoted fracture h …
Moreover, in vitro, overexpression of miR-1224-5p slowed Rankl-induced osteoclast differentiation and promoted osteoblast differentiation vi …
ADCY2 rs10059539 C>T polymorphism confers a decreased risk of hepatocellular carcinoma in Chinese Han women.
Chao X, Miao F, Feng X, Shi H, Wang Y, Wu J, Zhao L, Zhang W, Jiang C. Chao X, et al. Eur J Cancer Prev. 2021 Sep 1;30(5):351-356. doi: 10.1097/CEJ.0000000000000638. Eur J Cancer Prev. 2021. PMID: 34010241 Retracted.
OBJECTIVE: Hepatocellular carcinoma (HCC) poses a serious threat to human health. ADCY2 gene polymorphisms may be related to HCC susceptibility. Therefore, we investigated whether ADCY2 gene polymorphisms are correlated to the risk of HCC in a Chinese Han population …
OBJECTIVE: Hepatocellular carcinoma (HCC) poses a serious threat to human health. ADCY2 gene polymorphisms may be related to HCC susc …
circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis.
Wei W, Pan J, Wang J, Mao S, Qian Y, Lin X, Ling Q, Ye W, Zhou Y, Zhao Y, Huang J, Huang X, Ma Z, Wang H, Li C, Sun J, Jin J. Wei W, et al. Mol Carcinog. 2023 Oct;62(10):1546-1562. doi: 10.1002/mc.23598. Epub 2023 Jul 26. Mol Carcinog. 2023. PMID: 37493101
Mechanistically, circSLC25A13 played as a microRNA sponge of miR-616-3p, which inhibited the expression of adenylate cyclase 2 (ADCY2). Downregulation of miR-616-3p and overexpression of ADCY2 partially rescued circSLC25A13 deficient induced cell growth arrest. In s …
Mechanistically, circSLC25A13 played as a microRNA sponge of miR-616-3p, which inhibited the expression of adenylate cyclase 2 (ADCY2 …
Molecular cloning, sequence identification, and gene expression analysis of bovine ADCY2 gene.
Li YX, Jin HG, Yan CG, Ren CY, Jiang CJ, Jin CD, Seo KS, Jin X. Li YX, et al. Mol Biol Rep. 2014 Jun;41(6):3561-8. doi: 10.1007/s11033-014-3167-9. Epub 2014 May 6. Mol Biol Rep. 2014. PMID: 24797538
Analyses of the putative protein sequence showed that ADCY2 had high homology among species, except with the non-mammal Oreochromis niloticus. ...These data will serve as a foundation for further insight into the cattle ADCY2 gene....
Analyses of the putative protein sequence showed that ADCY2 had high homology among species, except with the non-mammal Oreochromis n …
Estrogen Promotes cAMP Production in Mesenchymal Stem Cells by Regulating ADCY2.
Zhao G, Li X, Miao H, Chen S, Hou Y. Zhao G, et al. Int J Stem Cells. 2020 Mar 30;13(1):55-64. doi: 10.15283/ijsc19139. Int J Stem Cells. 2020. PMID: 32114743 Free PMC article.
We confirmed that the expression of ADCY2 is significantly promoted by E2 and subsequently promoted the production of cAMP in MSCs. We also found that E2 promoted ADCY2 expression by inhibiting miR-152 and miR-148a. CONCLUSIONS: E2 promotes the expression of cAMP th …
We confirmed that the expression of ADCY2 is significantly promoted by E2 and subsequently promoted the production of cAMP in MSCs. W …
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2.
Petersen JE, Pedersen MH, Dmytriyeva O, Nellemose E, Arora T, Engelstoft MS, Asher WB, Javitch JA, Schwartz TW, Trauelsen M. Petersen JE, et al. Mol Metab. 2023 Aug;74:101757. doi: 10.1016/j.molmet.2023.101757. Epub 2023 Jun 20. Mol Metab. 2023. PMID: 37348738 Free PMC article.
Co-transfection with ADCY2 increased the FFAR1-induced cAMP response 4-5-fold in WT HEK293 cells, an effect fully inhibited by YM253890. Moreover, co-transfection with ADCY2 had no effect in Gq-deficient cells without reintroduction of either Gq or G11. ...
Co-transfection with ADCY2 increased the FFAR1-induced cAMP response 4-5-fold in WT HEK293 cells, an effect fully inhibited by YM2538 …
Investigation of the impact of an ADCY2 polymorphism as a predictive biomarker in bipolar disorder, suicide tendency and response to lithium carbonate therapy: the first report from Iran.
Aghabozorg Afjeh SS, Shams J, Hamednia S, Boshehri B, Olfat A, Omrani MD. Aghabozorg Afjeh SS, et al. Pharmacogenomics. 2020 Sep;21(14):1011-1020. doi: 10.2217/pgs-2020-0058. Epub 2020 Sep 7. Pharmacogenomics. 2020. PMID: 32893730
High rates of mortality due to both suicide and medical comorbidities in bipolar patients can be decreased through the administration of lithium, which affects the cerebral endothelium as well as neurons. To investigate the role of ADCY2 in risk of bipolar disorder, we gen …
High rates of mortality due to both suicide and medical comorbidities in bipolar patients can be decreased through the administration of lit …
CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.
Hardin M, Zielinski J, Wan ES, Hersh CP, Castaldi PJ, Schwinder E, Hawrylkiewicz I, Sliwinski P, Cho MH, Silverman EK. Hardin M, et al. Am J Respir Cell Mol Biol. 2012 Aug;47(2):203-8. doi: 10.1165/rcmb.2012-0011OC. Epub 2012 Mar 29. Am J Respir Cell Mol Biol. 2012. PMID: 22461431 Free PMC article.
CHRNA3/5 (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.5-2.4; P = 7.4 10(-7)), IREB2 (OR, 0.69; 95% CI, 0.5-0.9; P = 3.4 10(-3)), and ADCY2 (OR, 1.35; 95% CI, 1.1-1.7; P = 0.01) demonstrated significant associations with COPD. FAM13A (OR, 0.8; 95% CI, 0.7-1.0; P …
CHRNA3/5 (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.5-2.4; P = 7.4 10(-7)), IREB2 (OR, 0.69; 95% CI, 0.5-0.9; P = 3.4 10(-3)), …
A Novel Lipid Prognostic Signature of ADCY2, LIPE, and OLR1 in Head and Neck Squamous Cell Carcinoma.
Gao X, Zhao N, Dong L, Zheng X, Zhang Y, Ding C, Zhao S, Ma Z, Wang Y. Gao X, et al. Front Oncol. 2021 Nov 25;11:735993. doi: 10.3389/fonc.2021.735993. eCollection 2021. Front Oncol. 2021. PMID: 34900686 Free PMC article.
A novel lipid-related mRNA prognostic signature (LRPS, consisting of ADCY2, LIPE and OLR1) was developed, which could predict the survival and prognosis of HNSCC patients as an independent effective prognostic factor. ...A total number of 498 patients from TCGA with comple …
A novel lipid-related mRNA prognostic signature (LRPS, consisting of ADCY2, LIPE and OLR1) was developed, which could predict the sur …
93 results