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2013 1
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21 results

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Page 1
Characterization and prognostic impact of ACTBL2-positive tumor-infiltrating leukocytes in epithelial ovarian cancer.
Topalov NE, Mayr D, Kuhn C, Leutbecher A, Scherer C, Kraus FBT, Tauber CV, Beyer S, Meister S, Hester A, Kolben T, Burges A, Mahner S, Trillsch F, Kessler M, Jeschke U, Czogalla B. Topalov NE, et al. Sci Rep. 2023 Dec 18;13(1):22620. doi: 10.1038/s41598-023-49286-9. Sci Rep. 2023. PMID: 38114558 Free PMC article.
Actin beta-like 2 (ACTBL2) was recently identified as a new mediator of migration in ovarian cancer cells. ...Our results provide significant evidence of the prognostic impact and cellular composition of ACTBL2-expressing TILs in EOC. Complementary studies are requi …
Actin beta-like 2 (ACTBL2) was recently identified as a new mediator of migration in ovarian cancer cells. ...Our results provide sig …
The origin of the expressed retrotransposed gene ACTBL2 and its influence on human melanoma cells' motility and focal adhesion formation.
Malek N, Michrowska A, Mazurkiewicz E, Mrówczyńska E, Mackiewicz P, Mazur AJ. Malek N, et al. Sci Rep. 2021 Feb 8;11(1):3329. doi: 10.1038/s41598-021-82074-x. Sci Rep. 2021. PMID: 33558623 Free PMC article.
We also discovered that ACTBL2 is expressed at a very low level in several melanoma cell lines, but a small subset of cells exhibited a high ACTBL2 expression. We found that clones with knocked-out ACTBL2 (CR-ACTBL2) or overexpressing actbl2 (OE …
We also discovered that ACTBL2 is expressed at a very low level in several melanoma cell lines, but a small subset of cells exhibited …
Are non-muscle actin isoforms functionally equivalent?
Simiczyjew A, Pietraszek-Gremplewicz K, Mazur AJ, Nowak D. Simiczyjew A, et al. Histol Histopathol. 2017 Nov;32(11):1125-1139. doi: 10.14670/HH-11-896. Epub 2017 Apr 25. Histol Histopathol. 2017. PMID: 28439872 Review.
Two of them, beta and gamma non-muscle actin isoforms, which differ only by four amino acids located at the N-terminus of the polypeptide chain, are required for survival and proper cell functioning. We also summarized data about actbl2, which is suggested to be a newly di …
Two of them, beta and gamma non-muscle actin isoforms, which differ only by four amino acids located at the N-terminus of the polypeptide ch …
The expression pattern of ACTBL2 in thymoma reveals its potential therapeutic target efficacy.
Liu M, Meng Q. Liu M, et al. J BUON. 2020 Sep-Oct;25(5):2496-2503. J BUON. 2020. PMID: 33277874 Free article.
METHODS: We identified a series of non-coding (nc) RNAs (including BCL11A, miR-3977, miR-4460 and miR-542-3p) and TF (FAM185A, MGAM2, SEC14L4, ACTBL2), and predicted transcription factors (including AHR, ATF4, CEBPA and DDIT3) that have significant regulatory effects on th …
METHODS: We identified a series of non-coding (nc) RNAs (including BCL11A, miR-3977, miR-4460 and miR-542-3p) and TF (FAM185A, MGAM2, SEC14L …
Identification of actin beta-like 2 (ACTBL2) as novel, upregulated protein in colorectal cancer.
Ghazanfar S, Fatima I, Aslam M, Musharraf SG, Sherman NE, Moskaluk C, Fox JW, Akhtar MW, Sadaf S. Ghazanfar S, et al. J Proteomics. 2017 Jan 30;152:33-40. doi: 10.1016/j.jprot.2016.10.011. Epub 2016 Oct 27. J Proteomics. 2017. PMID: 27989943
Thus ACTBL2 association and differential upregulation in colorectal cancer is novel, and as such may contribute to our understanding of the colorectal carcinogenesis and potentially serve a function in developing markers for colorectal cancer. ...We corroborated the findin …
Thus ACTBL2 association and differential upregulation in colorectal cancer is novel, and as such may contribute to our understanding …
TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells.
Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T. Hödebeck M, et al. Front Physiol. 2014 Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014. Front Physiol. 2014. PMID: 25520667 Free PMC article.
Subsequent in silico analyses suggested that this transcription factor binds to the promotor region of ACTBL2 encoding kappa-actin which was shown to be abundantly expressed in VSMCs upon exposure to biomechanical stretch. Furthermore, ACTBL2 expression was inhibite …
Subsequent in silico analyses suggested that this transcription factor binds to the promotor region of ACTBL2 encoding kappa-actin wh …
Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer.
Topalov NE, Mayr D, Scherer C, Chelariu-Raicu A, Beyer S, Hester A, Kraus F, Zheng M, Kaltofen T, Kolben T, Burges A, Mahner S, Trillsch F, Jeschke U, Czogalla B. Topalov NE, et al. Front Oncol. 2021 Sep 23;11:713026. doi: 10.3389/fonc.2021.713026. eCollection 2021. Front Oncol. 2021. PMID: 34631538 Free PMC article.
Aiming to assess the molecular impact of ACTBL2 on cellular characteristics, functional assays were executed in vitro upon siRNA knockdown of ACTBL2 and NFAT5. ACTBL2 expression was identified as an independent negative prognostic factor for overall survival …
Aiming to assess the molecular impact of ACTBL2 on cellular characteristics, functional assays were executed in vitro upon siRNA knoc …
Enhanced ileum function in weaned piglets via Laminaria digitata and alginate lyase dietary inclusion: A combined proteomics and metabolomics analysis.
Ribeiro DM, Leclercq CC, Charton SAB, Costa MM, Carvalho DFP, Cocco E, Sergeant K, Renaut J, Freire JPB, Prates JAM, de Almeida AM. Ribeiro DM, et al. J Proteomics. 2023 Oct 30;289:105013. doi: 10.1016/j.jprot.2023.105013. Epub 2023 Sep 27. J Proteomics. 2023. PMID: 37775079
Additionally, the inclusion of seaweed fostered a rise in proteins linked to enhanced enterocyte structural integrity (ACTBL2, CRMP1, FLII, EML2 and MYLK), elevated peptidase activity (NAALADL1 and CAPNS1), and heightened anti-inflammatory activity (C3), underscoring impro …
Additionally, the inclusion of seaweed fostered a rise in proteins linked to enhanced enterocyte structural integrity (ACTBL2, CRMP1, …
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H, Hu R, Hu G. Cong M, et al. Nat Cancer. 2020 Feb;1(2):222-234. doi: 10.1038/s43018-019-0021-y. Epub 2020 Jan 20. Nat Cancer. 2020. PMID: 35122005
Mechanistically, MTSS1 interacts with the E3 ligase RanBP2-type and C3HC4-type zinc finger containing 1 (RBCK1) to facilitate RBCK1-mediated p65 ubiquitination and degradation, thus suppressing the NF-kappaB signaling pathway and tumorigenesis. In addition, actin beta-like 2 ( …
Mechanistically, MTSS1 interacts with the E3 ligase RanBP2-type and C3HC4-type zinc finger containing 1 (RBCK1) to facilitate RBCK1-mediated …
Proteomic analysis for identifying the differences in molecular profiling between fanconi anaemia and aplastic anaemia.
Hou H, Li D, Yao YH, Lu J, Sun YN, Hu YX, Wu SY, Chu XR, Xiao PF, Xu GQ, Hu SY. Hou H, et al. Am J Transl Res. 2019 Oct 15;11(10):6522-6533. eCollection 2019. Am J Transl Res. 2019. PMID: 31737203 Free PMC article.
Eight hub proteins with a high degree of connectivity were obtained as follows: alpha-enolase (ENO1), HSP90AA1, phosphoglycerate kinase 1 (PGK1), HSP90AB1, ACTC1, ACTBL2, EEF1A1 and CFL1. Upregulation of ENO1 and CFL1 in patients with FA was confirmed through a WB experime …
Eight hub proteins with a high degree of connectivity were obtained as follows: alpha-enolase (ENO1), HSP90AA1, phosphoglycerate kinase 1 (P …
21 results