Abstract
Comparison of peptidase gene families in the newly released Drosophila melanogaster and Caenorhabditis elegans genomes highlights important differences in peptidase distributions with relevance to the evolution of both form and function in these two organisms and can help to identify the most appropriate model when using comparative studies relevant to the human condition.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Caenorhabditis elegans / genetics*
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Drosophila melanogaster / genetics*
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Genome
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Invertebrates
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Matrix Metalloproteinases / genetics
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Metalloendopeptidases / genetics
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Neprilysin / genetics
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Neuropeptides / genetics
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Neuropeptides / physiology*
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Peptide Hydrolases / genetics
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Peptide Hydrolases / physiology*
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Peptidyl-Dipeptidase A / genetics
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Phenotype
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Phylogeny
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Serine Endopeptidases / genetics
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Zinc / metabolism
Substances
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Neuropeptides
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Peptide Hydrolases
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Peptidyl-Dipeptidase A
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Serine Endopeptidases
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Matrix Metalloproteinases
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Metalloendopeptidases
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Neprilysin
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Zinc