Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function

Biochem Soc Trans. 2000;28(4):464-9.

Abstract

Comparison of peptidase gene families in the newly released Drosophila melanogaster and Caenorhabditis elegans genomes highlights important differences in peptidase distributions with relevance to the evolution of both form and function in these two organisms and can help to identify the most appropriate model when using comparative studies relevant to the human condition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Drosophila melanogaster / genetics*
  • Genome
  • Invertebrates
  • Matrix Metalloproteinases / genetics
  • Metalloendopeptidases / genetics
  • Neprilysin / genetics
  • Neuropeptides / genetics
  • Neuropeptides / physiology*
  • Peptide Hydrolases / genetics
  • Peptide Hydrolases / physiology*
  • Peptidyl-Dipeptidase A / genetics
  • Phenotype
  • Phylogeny
  • Serine Endopeptidases / genetics
  • Zinc / metabolism

Substances

  • Neuropeptides
  • Peptide Hydrolases
  • Peptidyl-Dipeptidase A
  • Serine Endopeptidases
  • Matrix Metalloproteinases
  • Metalloendopeptidases
  • Neprilysin
  • Zinc