Similar articles for PMID: 19934398

Year	Number of Results
2000	1
2004	1
2005	2
2006	2
2007	3
2008	6
2009	7
2010	4
2011	3
2012	5
2013	7
2014	5
2015	8
2016	7
2017	5
2018	10
2019	16
2020	14
2021	16
2022	4
2023	6
2024	0

1

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Putcha P, et al. J Pharmacol Exp Ther. 2010 Mar;332(3):849-57. doi: 10.1124/jpet.109.158436. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934398 Free PMC article.

2

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.

McFarland NR, Dimant H, Kibuuka L, Ebrahimi-Fakhari D, Desjardins CA, Danzer KM, Danzer M, Fan Z, Schwarzschild MA, Hirst W, McLean PJ. McFarland NR, et al. PLoS One. 2014 Jan 20;9(1):e86048. doi: 10.1371/journal.pone.0086048. eCollection 2014. PLoS One. 2014. PMID: 24465863 Free PMC article.

3

14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.

Wang B, Underwood R, Kamath A, Britain C, McFerrin MB, McLean PJ, Volpicelli-Daley LA, Whitaker RH, Placzek WJ, Becker K, Ma J, Yacoubian TA. Wang B, et al. J Neurosci. 2018 Sep 19;38(38):8211-8232. doi: 10.1523/JNEUROSCI.1134-18.2018. Epub 2018 Aug 9. J Neurosci. 2018. PMID: 30093536 Free PMC article.

4

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, Freed T, Steed PM, Ommen AJ, Smith ED, Hughes PF, Woodward AR, Hanson GJ, McCall WS, Markworth CJ, Hinkley L, Jenks M, Geng L, Lewis M, Otto J, Pronk B, Verleysen K, Hall SE. Huang KH, et al. J Med Chem. 2009 Jul 23;52(14):4288-305. doi: 10.1021/jm900230j. J Med Chem. 2009. PMID: 19552433

5

Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters.

Aelvoet SA, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V. Aelvoet SA, et al. J Neurosci. 2014 Dec 3;34(49):16518-32. doi: 10.1523/JNEUROSCI.4933-13.2014. J Neurosci. 2014. PMID: 25471588 Free PMC article.

6

Applying chaperones to protein-misfolding disorders: molecular chaperones against α-synuclein in Parkinson's disease.

Chaari A, Hoarau-Véchot J, Ladjimi M. Chaari A, et al. Int J Biol Macromol. 2013 Sep;60:196-205. doi: 10.1016/j.ijbiomac.2013.05.032. Epub 2013 Jun 5. Int J Biol Macromol. 2013. PMID: 23748003 Review.

7

CHIP targets toxic alpha-Synuclein oligomers for degradation.

Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. Tetzlaff JE, et al. J Biol Chem. 2008 Jun 27;283(26):17962-8. doi: 10.1074/jbc.M802283200. Epub 2008 Apr 24. J Biol Chem. 2008. PMID: 18436529 Free PMC article.

8

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.

Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, Taglialatela G. Martin ZS, et al. J Neurochem. 2012 Feb;120(3):440-52. doi: 10.1111/j.1471-4159.2011.07576.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22060133 Free PMC article.

9

A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.

Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D. Xiong R, et al. Mol Pharmacol. 2015 Dec;88(6):1045-54. doi: 10.1124/mol.115.101451. Epub 2015 Sep 24. Mol Pharmacol. 2015. PMID: 26405178 Free PMC article.

10

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.

Park JH, Burgess JD, Faroqi AH, DeMeo NN, Fiesel FC, Springer W, Delenclos M, McLean PJ. Park JH, et al. Mol Neurodegener. 2020 Jan 13;15(1):5. doi: 10.1186/s13024-019-0349-x. Mol Neurodegener. 2020. PMID: 31931835 Free PMC article.

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