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Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.

Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T. Ikeda F, et al. J Clin Invest. 2004 Aug;114(4):475-84. doi: 10.1172/JCI19657. J Clin Invest. 2004. PMID: 15314684 Free PMC article.

TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.

Kanazawa K, Kudo A. Kanazawa K, et al. J Bone Miner Res. 2005 May;20(5):840-7. doi: 10.1359/JBMR.041225. Epub 2004 Dec 20. J Bone Miner Res. 2005. PMID: 15824857 Free article.

Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos: a possible mechanism for downregulation of osteoclastogenesis.

Kamel Mohamed SG, Sugiyama E, Shinoda K, Hounoki H, Taki H, Maruyama M, Miyahara T, Kobayashi M. Kamel Mohamed SG, et al. Biochem Biophys Res Commun. 2005 Apr 15;329(3):839-45. doi: 10.1016/j.bbrc.2005.02.049. Biochem Biophys Res Commun. 2005. PMID: 15752732

BSP and RANKL induce osteoclastogenesis and bone resorption synergistically.

Valverde P, Tu Q, Chen J. Valverde P, et al. J Bone Miner Res. 2005 Sep;20(9):1669-79. doi: 10.1359/JBMR.050511. Epub 2005 May 16. J Bone Miner Res. 2005. PMID: 16059638 Free article.

Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1.

Takatsuna H, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K. Takatsuna H, et al. J Bone Miner Res. 2005 Apr;20(4):653-62. doi: 10.1359/JBMR.041213. Epub 2004 Dec 6. J Bone Miner Res. 2005. PMID: 15765185 Free article.

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T. Takayanagi H, et al. Dev Cell. 2002 Dec;3(6):889-901. doi: 10.1016/s1534-5807(02)00369-6. Dev Cell. 2002. PMID: 12479813 Free article.

c-myc is required for osteoclast differentiation.

Battaglino R, Kim D, Fu J, Vaage B, Fu XY, Stashenko P. Battaglino R, et al. J Bone Miner Res. 2002 May;17(5):763-73. doi: 10.1359/jbmr.2002.17.5.763. J Bone Miner Res. 2002. PMID: 12009006 Free article.

Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells.

Mohamed SG, Sugiyama E, Shinoda K, Taki H, Hounoki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Ogawa H, Miyahara T. Mohamed SG, et al. Bone. 2007 Oct;41(4):592-602. doi: 10.1016/j.bone.2007.05.016. Epub 2007 Jun 13. Bone. 2007. PMID: 17627913

Inhibition of receptor activator of nuclear factor-κB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.

Koide N, Kondo Y, Odkhuu E, Ulziisaikhan J, Ukaji T, Yokochi T, Umezawa K. Koide N, et al. Immunol Lett. 2014 Sep;161(1):31-7. doi: 10.1016/j.imlet.2014.04.006. Epub 2014 May 2. Immunol Lett. 2014. PMID: 24792671

Coenzyme q10 regulates osteoclast and osteoblast differentiation.

Moon HJ, Ko WK, Jung MS, Kim JH, Lee WJ, Park KS, Heo JK, Bang JB, Kwon IK. Moon HJ, et al. J Food Sci. 2013 May;78(5):H785-891. doi: 10.1111/1750-3841.12116. Epub 2013 Apr 12. J Food Sci. 2013. PMID: 23582186

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