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11238922,12370293,11103932,11438644,9889196,10772807,9840932,7838523,12724424,12359725,10878006,9468218,9388487,8637717,10942577,9632134,10995387,9003781,11257126,10783242,11581254,10359664,9108451,7589260,10559988,9425288,10047461,9858587,12810668,11884610,11953320,11154267,11513744,9710622,11416152,10942587,8853893,9918914,10918595,12857729,16081423,9094315,9869641,9724724,10229195,15601848,11175348,10708481,11340163,11533444,9829836,7488142,10867026,9472014,9407125,10995386,14551212,25860957,12501191,10551888,10373534,8943316,8560263,10982843,11943869,8979268,15004027,12354776,9029153,8861947,17495531,12947099,10906181,10884410,11132966,12676926,10085115,11113184,11369759,16024922,8301538,9858588,12419181,11706002,11907280,11980914,14699150,8443411,12173048,14612406,12081504,11676600,11278991,16431923,16446360,11304535,10936504,10790398,8475101,9710638,9696820,9922449,12149264,11236929,11733001,8591034,10519216,8999795,8810285,15964852,9882337,10806104,11283255,11408575,9826690,19858290,9087377,1517236,9864142,7553852,21945277,7569954,7642695,12930830,8242751,7698977,10931829,14572899,10751146,10938080,7621701,9251027,10433828,11745413,8756624,11237594,15671017,14652010,10330164,12941268,10095772,9823900,8242750,12588988,7874496,1532660,11452014,9105046,8887674,12651890,14612403,15980415,10910135,8127873,10652300,9671462,9933170,10748114,12429912,1396589,9731536,12724400,11738041,15355984,8475104,10930425,11076534,19150984,10938106,12475960,15159402,11287574,12482952,14985333,9268577,8601310,10962581,26861625,9372912,12970441,15988025,9858585,11230108,10200261,14657672,12172026,8207080,9632748,12036957,1475706,10805723,8769642,11997503,15855168,11726663,11296295,19029251,11051553,33210757,10626899,8591024,24022486,12351729,1329201,11438650,15824106,10692408,11029659,8964491,16308562,8752210,11029468,11705873,11684017,16191191,12815053,9683792,11549591,12364325,9679057,1312467,19170105,21088490,8308077,9294175,11604388,8402887,8397206,14701826,15744308,11454864,12221087,10196317,11714273,8798463,11781350,11359766,10793138,12236581,11461705,12044161,14597612,11486031,12105215,14561402,10428798,25548279,12745075,1518810,10454565,15133678,8266103,1535244,12084729,8591023,15197472,11264176,16262255,15247247,11588240,11827161,10828061,9261366,9626358,10380937,9001207,1714386,8458862,10656618,12485874,1372993,11956189,10871384,16954377,15722557,9278499,11349131,14536078,11884622,8799808,12729791,15753125,15607961,11502743,9891042,10339564,25619768,11802789,11504716,8781234,11532001,9552413,15115752,12588990,9552358,9141623,9560221,8800213,15660127,10778740,11402021,11418614,17015463,8251505,7622566,16581770,21099355,21807893,10998356,8078587,12759351,11498537,9280344,11494044,8163865,11067844,8828805,28132839,12947101,16378951,9071705,10921241,8510751,21325496,25049391,17198398,11095697,15955820,11463386,7732022,20215406,12869192,28056778,8539622,17826007,10995786,12600080,8500168,10958787,10525536,8727661,9243501,7552724,9632813,16020661,10320381,17638878,11230113,26429916,29665367,14993212,12732645,11287748,9251019,8670864,10487753,7633437,17293600,12726855,22584582,9063745,10846177,9395203,9426687,8730095,19423708,12716909,12929089,23671119,11287628,15649889,9616080,10092646,14506259,18794371,11027291,15067004,14624238,10936682,11113154,12897141,12134018,11602254,21646402,27005485,18332217,10575231,8550604,16540140,11724777,9733854,15200949,10580002,20810654,12140753,17698606,10455103,16188887,14726682,17361108,9584169,10490639,16504183,18356301,1652372,11801729,11524422,12386167,1279696,16294044,35595767,15749021,9819444,15141303,11071782,9620273,9611274,8631817,17804818,23264631,11395479,23781148,18336471,34085229,16082198,12170178,22331465,17376478,15016823,27828963,15905174,10500095,15606011,14656438,15178429,11584302,11553343,26266831,10929103,10877824,17218276,12121977,11919196,9677190,18959818,18559500,7615496,12429741,12898219,12182847,9647650,21217199,10934208,8626446,31309634,28137908,7568034,12695516,25429106,12729926,9521129,12207013,36961375,16118210,23028682,19781672,9251007,12695666,11110801,12167630,12407107,21092281,32553169,1833068,27815502,12204665,12356752,27448301,9013862,16980972,17568194,14623875,25409301,11163436,11278837,19901524,9017598,17255359,25918937,15173007,12123447,24101496,12665514,14659740,11113136,30305396,8647814,15235594,16582606,10934199,8549800,21816347,20139727,37104883,16875671,9504914,15621527,12588977,15696186,16546994,15797862,22588722,25728284,22796189,18245951,23065011,11342215,11891112,11816025,10722661,11346650,30082790,11318983,22401310,11166203,16455663,9820826,15136770,15127225,10373465,21347226,9552396,16082227,9573348,8681138,14749377,9393434,9861450,18490441,9487122,14675149,12398936,11416138,11709559,15695825,23316279,27182644,22951823,17689156,18615713,16611745,20514425,18354084,11584018,12857883,15576935,12562757,12851383,11395523,12560341,15611618,11477067,17207919,17373709,19773423,8611624,12872229,12535642,12588995,11824754,19033152,19829063,118176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HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.

Hall C, Nelson DM, Ye X, Baker K, DeCaprio JA, Seeholzer S, Lipinski M, Adams PD. Hall C, et al. Mol Cell Biol. 2001 Mar;21(5):1854-65. doi: 10.1128/MCB.21.5.1854-1865.2001. Mol Cell Biol. 2001. PMID: 11238922 Free PMC article.

Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity.

Nelson DM, Ye X, Hall C, Santos H, Ma T, Kao GD, Yen TJ, Harper JW, Adams PD. Nelson DM, et al. Mol Cell Biol. 2002 Nov;22(21):7459-72. doi: 10.1128/MCB.22.21.7459-7472.2002. Mol Cell Biol. 2002. PMID: 12370293 Free PMC article.

Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells.

Sandhu C, Donovan J, Bhattacharya N, Stampfer M, Worland P, Slingerland J. Sandhu C, et al. Oncogene. 2000 Nov 9;19(47):5314-23. doi: 10.1038/sj.onc.1203908. Oncogene. 2000. PMID: 11103932

Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinases.

Wohlschlegel JA, Dwyer BT, Takeda DY, Dutta A. Wohlschlegel JA, et al. Mol Cell Biol. 2001 Aug;21(15):4868-74. doi: 10.1128/MCB.21.15.4868-4874.2001. Mol Cell Biol. 2001. PMID: 11438644 Free PMC article.

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.

Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K. Petersen BO, et al. EMBO J. 1999 Jan 15;18(2):396-410. doi: 10.1093/emboj/18.2.396. EMBO J. 1999. PMID: 9889196 Free PMC article.

Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)-independent Cdk2 inhibition in human carcinoma T47D-H3 cells.

Bilodeau JF, Faure R, Piedboeuf B, Mirault ME. Bilodeau JF, et al. Exp Cell Res. 2000 May 1;256(2):347-57. doi: 10.1006/excr.2000.4844. Exp Cell Res. 2000. PMID: 10772807

The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.

Saville MK, Watson RJ. Saville MK, et al. Oncogene. 1998 Nov 26;17(21):2679-89. doi: 10.1038/sj.onc.1202503. Oncogene. 1998. PMID: 9840932

Phosphorylation of E2F-1 by cyclin A-cdk2.

Kitagawa M, Higashi H, Suzuki-Takahashi I, Segawa K, Hanks SK, Taya Y, Nishimura S, Okuyama A. Kitagawa M, et al. Oncogene. 1995 Jan 19;10(2):229-36. Oncogene. 1995. PMID: 7838523

The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.

Wei Y, Jin J, Harper JW. Wei Y, et al. Mol Cell Biol. 2003 May;23(10):3669-80. doi: 10.1128/MCB.23.10.3669-3680.2003. Mol Cell Biol. 2003. PMID: 12724424 Free PMC article.

Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.

Lents NH, Keenan SM, Bellone C, Baldassare JJ. Lents NH, et al. J Biol Chem. 2002 Dec 6;277(49):47469-75. doi: 10.1074/jbc.M207425200. Epub 2002 Sep 30. J Biol Chem. 2002. PMID: 12359725 Free article.

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