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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 2
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1983 2
1984 5
1985 3
1986 3
1987 2
1988 3
1989 1
1990 7
1991 2
1992 2
1993 5
1994 6
1995 1
1996 3
1997 3
1998 5
1999 2
2000 5
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70 results

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Page 1
Phosphorothioates, essential components of therapeutic oligonucleotides.
Eckstein F. Eckstein F. Nucleic Acid Ther. 2014 Dec;24(6):374-87. doi: 10.1089/nat.2014.0506. Nucleic Acid Ther. 2014. PMID: 25353652 Review.
It continues with applications where the target RNA should not be cleaved. A brief presentation of decoy oligonucleotides will be included, as well as some miscellaneous applications. Cellular uptake is a crucial step for oligonucleotides to reach their target and w …
It continues with applications where the target RNA should not be cleaved. A brief presentation of decoy oligonucleotides will be inc …
The versatility of oligonucleotides as potential therapeutics.
Eckstein F. Eckstein F. Expert Opin Biol Ther. 2007 Jul;7(7):1021-34. doi: 10.1517/14712598.7.7.1021. Expert Opin Biol Ther. 2007. PMID: 17665991 Review.
Oligonucleotides can in a variety of ways inhibit gene expression by interfering with translation. Oligonucleotides that are complementary to a target mRNA, antisense oligonucleotides, can prevent translation either by cleaving the target or by physically blo …
Oligonucleotides can in a variety of ways inhibit gene expression by interfering with translation. Oligonucleotides that are c …
Small non-coding RNAs as magic bullets.
Eckstein F. Eckstein F. Trends Biochem Sci. 2005 Aug;30(8):445-52. doi: 10.1016/j.tibs.2005.06.008. Trends Biochem Sci. 2005. PMID: 15996867 Review.
The application of siRNAs for both functional analysis of genes and medication raises several questions. These include the design of the double-stranded oligonucleotides, their preparation and introduction into cells or animals either as chemically synthesized entities or …
The application of siRNAs for both functional analysis of genes and medication raises several questions. These include the design of the dou …
Modified oligonucleotides: synthesis and strategy for users.
Verma S, Eckstein F. Verma S, et al. Among authors: eckstein f. Annu Rev Biochem. 1998;67:99-134. doi: 10.1146/annurev.biochem.67.1.99. Annu Rev Biochem. 1998. PMID: 9759484 Review.
Synthetic oligonucleotide analogs have greatly aided our understanding of several biochemical processes. ...In this chapter, we review the range, scope, and practical utility of such chemically modified oligonucleotides. Because of space limitations, we discuss only …
Synthetic oligonucleotide analogs have greatly aided our understanding of several biochemical processes. ...In this chapter, we revie …
Structure-function studies of the hammerhead ribozyme.
Verma S, Vaish NK, Eckstein F. Verma S, et al. Among authors: eckstein f. Curr Opin Chem Biol. 1997 Dec;1(4):532-6. doi: 10.1016/s1367-5931(97)80049-x. Curr Opin Chem Biol. 1997. PMID: 9667883 Review.
On the quality control of antisense oligonucleotides.
Eckstein F, Krieg AM, Stein CA, Agrawal S, Beaucage S, Cook PD, Crooke S, Gait MJ, Gewirtz A, Hélène C, Miller P, Narayanan R, Nicolin A, Nielsen P, Ohtsuka E, Seliger H, Stec W, Tidd D, Wagner R, Zon J. Eckstein F, et al. Antisense Nucleic Acid Drug Dev. 1996 Fall;6(3):149. doi: 10.1089/oli.1.1996.6.149. Antisense Nucleic Acid Drug Dev. 1996. PMID: 8915496 No abstract available.
Antisense technologies have a future fighting neurodegenerative diseases.
Seidman S, Eckstein F, Grifman M, Soreq H. Seidman S, et al. Among authors: eckstein f. Antisense Nucleic Acid Drug Dev. 1999 Aug;9(4):333-40. doi: 10.1089/oli.1.1999.9.333. Antisense Nucleic Acid Drug Dev. 1999. PMID: 10463077 Review.
Antisense technologies are ideally suited to this purpose. Tailor-designed to target specific RNA, antisense oligonucleotides and ribozymes offer tools to suppress the production of proteins mediating neurodegeneration. ...
Antisense technologies are ideally suited to this purpose. Tailor-designed to target specific RNA, antisense oligonucleotides and rib …
Side-effects and phosphorothioates.
Eckstein F. Eckstein F. Nat Biotechnol. 2002 Jun;20(6):549. doi: 10.1038/nbt0602-549a. Nat Biotechnol. 2002. PMID: 12042851 No abstract available.
Incorporation of terminal phosphorothioates into oligonucleotides.
Alefelder S, Patel BK, Eckstein F. Alefelder S, et al. Among authors: eckstein f. Nucleic Acids Res. 1998 Nov 1;26(21):4983-8. doi: 10.1093/nar/26.21.4983. Nucleic Acids Res. 1998. PMID: 9776763 Free PMC article.
Considerable effort has been directed towards studying the structure and function of oligonucleotides and several approaches rely on the attachment of reporter groups to oligonucleotides. We report here the introduction of 3'- and 5'-terminal phosphorothioates into …
Considerable effort has been directed towards studying the structure and function of oligonucleotides and several approaches rely on …
70 results