Abstract
Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.
MeSH terms
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Azides / pharmacology*
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Candida / drug effects*
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Chronic Disease
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Cyanides / pharmacology*
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Granuloma / blood
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Humans
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Hydrogen Peroxide / metabolism
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Infant, Newborn
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Infant, Newborn, Diseases / blood
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Infections / blood
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Lactobacillus acidophilus / drug effects*
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Leukocytes / enzymology*
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Lymphadenitis / blood
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Male
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Metabolism, Inborn Errors
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Peroxidases / antagonists & inhibitors*
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Peroxidases / blood*
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Staphylococcus / drug effects*
Substances
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Azides
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Cyanides
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Hydrogen Peroxide
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Peroxidases