Abstract
The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Chromosome Mapping*
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Crosses, Genetic
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DNA-Activated Protein Kinase
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DNA-Binding Proteins*
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Mice
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Mice, SCID / genetics*
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Molecular Sequence Data
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Muridae
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Mutation*
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Polymorphism, Genetic
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Protein Serine-Threonine Kinases / genetics*
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Recombination, Genetic
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Severe Combined Immunodeficiency / genetics*
Substances
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DNA-Binding Proteins
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DNA-Activated Protein Kinase
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Protein Serine-Threonine Kinases