Abstract
Synovial fluid adenosine triphosphate pyrophosphohydrolase, an enzyme which manifests increased activity in chondrocalcinosis and osteoarthritis, was partially characterized in synovial fluids from 41 patients who had a variety of arthropathies. Activity was found to be a soluble, heat labile, and divalent cation-dependent nonspecific nucleotide pyrophosphohydrolase with pH optimum 9.0-9.5.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphatases / analysis*
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Adenosine Triphosphatases / antagonists & inhibitors
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Arthritis, Rheumatoid / enzymology
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Calcium Metabolism Disorders / enzymology
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Chromatography, Ion Exchange
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Gout / enzymology
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Humans
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Hydrogen-Ion Concentration
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Joint Diseases / blood
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Joint Diseases / enzymology*
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Kinetics
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Osteoarthritis / enzymology
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Pyrophosphatases*
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Substrate Specificity
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Synovial Fluid / enzymology*
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Uridine Diphosphate Glucose / metabolism
Substances
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Adenosine Triphosphatases
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Pyrophosphatases
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ATP pyrophosphohydrolase
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Uridine Diphosphate Glucose