Increased activity of pyridoxal kinase in tongue in Down's syndrome

S P Coburn; J D Mahuren; W E Schaltenbrand

doi:10.1111/j.1365-2788.1991.tb00452.x

Increased activity of pyridoxal kinase in tongue in Down's syndrome

J Ment Defic Res. 1991 Dec:35 ( Pt 6):543-7. doi: 10.1111/j.1365-2788.1991.tb00452.x.

Authors

S P Coburn¹, J D Mahuren, W E Schaltenbrand

Affiliation

¹ Biochemistry Department, Fort Wayne State Developmental Center, Indiana 46835.

PMID: 1839316
DOI: 10.1111/j.1365-2788.1991.tb00452.x

Abstract

The concentrations of B6 vitamins, and the activities of pyridoxal kinase, pyridoxamine phosphate oxidase and pyridoxal phosphate phosphatase were measured in tongue. Pyridoxal kinase activity was significantly greater (P less than 0.01) in Down's syndrome subjects compared with controls.

Publication types

Comparative Study
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adolescent
Adult
Child
Child, Preschool
Down Syndrome / blood
Down Syndrome / metabolism*
Female
Humans
Male
Middle Aged
Pyridoxal Kinase / blood*
Pyridoxal Phosphate / blood
Pyridoxine / administration & dosage
Pyridoxine / metabolism*
Tongue*

Substances

Pyridoxal Phosphate
Pyridoxal Kinase
Pyridoxine