Convertases other than furin cleave beta-secretase to its mature form

FASEB J. 2001 Aug;15(10):1810-2. doi: 10.1096/fj.00-0891fje.
No abstract available

MeSH terms

  • Alzheimer Disease / enzymology
  • Amyloid Precursor Protein Secretases
  • Animals
  • Aspartic Acid Endopeptidases / genetics
  • Aspartic Acid Endopeptidases / metabolism*
  • Cell Line
  • Endopeptidases
  • Enzyme Precursors / metabolism
  • Enzyme Stability
  • Furin
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation
  • Recombinant Proteins / metabolism
  • Serine Endopeptidases / metabolism*
  • Subtilisins / deficiency
  • Subtilisins / genetics
  • Subtilisins / metabolism*
  • Transfection

Substances

  • Enzyme Precursors
  • Recombinant Proteins
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Serine Endopeptidases
  • Subtilisins
  • Furin
  • Aspartic Acid Endopeptidases
  • BACE2 protein, human
  • BACE1 protein, human
  • Bace1 protein, mouse