Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians

F Thameem; J K Wolford; C Bogardus; M Prochazka

doi:10.1006/mgme.2001.3154

Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians

Mol Genet Metab. 2001 Apr;72(4):360-3. doi: 10.1006/mgme.2001.3154.

Authors

F Thameem¹, J K Wolford, C Bogardus, M Prochazka

Affiliation

¹ Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 4212 North 16th Street, Phoenix, Arizona 85016, USA. fthameem@mail.nih.gov

PMID: 11286512
DOI: 10.1006/mgme.2001.3154

Abstract

Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 diabetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population.

MeSH terms

Anemia, Megaloblastic / genetics
Arizona
Carrier Proteins / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 1 / genetics*
DNA Primers / chemistry
Diabetes Mellitus, Type 2 / ethnology*
Diabetes Mellitus, Type 2 / genetics
Disease Susceptibility
Exons
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Indians, North American / genetics*
Introns
Membrane Transport Proteins*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide

Substances

Carrier Proteins
DNA Primers
Membrane Transport Proteins
SLC19A2 protein, human