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26224291,29529618,29655497,26293224,34055474,23666589,36280158,31470454,35091036,17481929,26831479,33468344,28401341,25421958,26801677,30151929,31146571,27488378,34397615,26253269,22371896,29656981,27561596,22773397,19651948,24382724,26233784,30845037,34053300,28249976,30234625,26397726,27440566,11033554,26864855,19669849,25825157,20100413,24951731,35625278,19797586,30830037,32698642,22290130,20213514,22608685,33929342,17219829,30558680,18602187,23645338,26258318,19808441,31107376,30093266,20675336,32402578,8792993,31112072,26689584,27520693,19841968,18179914,29887199,26869065,23552769,26462348,30562290,32901395,24514089,28040397,12422090,29040128,29870449,22890771,26901276,21553797,19995312,26873243,21968901,33856366,15846464,32475280,33482673,34719272,19255223,23463287,30545448,24048091,22824854,35188900,22019197,31593059,12075382,31728604,16360328,24412247,27049212,18065867,24717822,23446823,20381287,19560786,31129555,10527443,30910245,24418770,30048880,11745530,26280681,29103776,18297449,20360210,17140514,26241469,31490860,16242027,19654529,33840539,29401093,16779814,34876010,29078909,11747694,25779885,34807762,12897501,24650025,26725710,30995208,26749522,21169530,25129595,11033559,31322947,11835177,30801375,7604344,28492106,31691335,28576711,36375749,20390472,20500808,11300297,24675203,8339575,23695383,28122314,28240419,26259793,8709381,28291188,22314530,29279933,31393339,33242142,35051610,8092833,27106640,2035760,19263587,9549786,23138708,8515103,14649677,28145954,29506833,25701387,31915682,28561169,3511759,12400768,30221380,14513443,30644281,36507629,15190554,26329794,19458950,30739547,26857632,25459073,27755287,29793587,9379707,25925714,31070495,32026706,29529619,21837686,32600192,1346815,32577466,23633187,30027615,33291550,28659322,28541147,25519076,28245229,10639702,30476297,8288664,33731164,22447433,33905919,28051245,32747743,27955626,30855592,24745317,29501602,1740934,27916373,25380688,27633945,36580056,18591602,31397077,17078078,32898359,26559541,29905629,26499129,28421546,9523322,25624333,26209148,29447384,12448241,29470904,32600673,28976634,10714971,27239017,31343489,14735075,16033021,29985244,9292578,9082104,32036473,25560964,28651885,28390182,26297104,30348572,30876673,27587217,28827508,36738866,34398899,10843394,10945814,34460441,31877146,31573423,27124826,9498450,28128093,28456368,24811854,30069504,34069492,22541145,8975446,28097503,32652630,32197146,22159247,3342127,26716084,20830204,12045594,10030599,35573772,10639356,29909051,22676321,32053565,27287137,35785460,12423612,28570348,27727049,6731687,32658180,31397701,15988258,25893337,16570547,30141716,6111670,3511760,15014292,35089196,20148647,3178333,28421514,31863932,33202066,29644481,21501065,28462459,27622281,30696456,16807815,29558373,1569669,30506486,36736635,30325073,35583546,28914105,22215478,36916725,33877055,2681652,30724762,1083096,11901320,21179910,29046121,25135015,1858734,14455426,14655003,8601899,9060514,18988275,12550049,29490404,33139277,30738405,6998390,29945163,35977680,25405131,1634811,27246239,30600188,23744500,9738752,8427396,3300580,320960,16708249,9177855,34243156,31256214,4053982,30479973,30134418,27198480,28466180,18459178,37088221,2258355,20162715,1879181,32810135,33913540,32133517,11030609,29239678,32072608,8814072,25769485,29701568,25557933,21792723,29254741,15577462,3873389,19060522,28094033,6749897,25483838,21485671,6662840,33375415,11857961,31736523,36920741,933218,2781408,8262097,31880853,36821410,526005,30542746,8789865,27116085,29632794,8934495,26487224,27384870,1564460,8109937,27886979,2798242,31816270,12746774,28601215,32839277,20116732,21151625,34084697,28652422,28400887,22391848,6372034,36113029,12754030,10172048,31349830,23271532,35278318,23271533,13827918,12075647,26964315,36853948,27137674,8462861,10951369,30994542,32398496,34505961,21868717,36671223,26817470,29222580,3346316,25774270,5142052,23120682,36008360,1866543,30675553,28003070,34094701,8449841,32447067,32095400,29955439,7567087,30845046,31758281,33571573,29231172,24193267,23182318,35222858,31461126,12533379,24904728,32940027,36672548,31461137,34859113,25932244,26818598,31005895,3619426,31566549,32745111,35903523,24977067,24926038,28344486,7016899,20922074,35453234,31356317,7890847,33804372,26929668,27122728,31318802,29894570,35775358,34336384,29539902,29299893,36988599,15220806,33615119,27657360,33404392,27654018,26025817,35745772,14172481,7206736,25861611,1357375,26970387,13030759,36687463,15220808,18651014,31954462,31954461,31954460,31954459,31954458,11442955,31540675,32541591,30781454,30352772,31954463,28433121,9145164,13889658,33665133,13223378,13865911,29240935,29149292,32397094,27666356,9125038,35737358,31901693,35737365,13357893,32118605,13282169,34208413,13382110,13289010,13388990,13484596,14956817,14391774,13547794,22529497,4098662,13254395,18898802,2861479,14107256,26694532,28483782,15403441,22359010,31748799,13102826,18124858,13320279,14042243,13320278,26678999,15423272,23487365,19310886,31632658,27653497,26229155,34558718,2021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Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA.

Young SW, Roberts T, Johnson S, Dalton JP, Coleman B, Wiles S. Young SW, et al. Clin Orthop Relat Res. 2015 Nov;473(11):3573-84. doi: 10.1007/s11999-015-4464-x. Epub 2015 Jul 30. Clin Orthop Relat Res. 2015. PMID: 26224291 Free PMC article.

The John N. Insall Award: Higher Tissue Concentrations of Vancomycin Achieved With Intraosseous Regional Prophylaxis in Revision TKA: A Randomized Controlled Trial.

Young SW, Zhang M, Moore GA, Pitto RP, Clarke HD, Spangehl MJ. Young SW, et al. Clin Orthop Relat Res. 2018 Jan;476(1):66-74. doi: 10.1007/s11999.0000000000000013. Clin Orthop Relat Res. 2018. PMID: 29529618 Free PMC article. Clinical Trial.

The AAHKS Clinical Research Award: Intraosseous Regional Prophylaxis Provides Higher Tissue Concentrations in High BMI Patients in Total Knee Arthroplasty: A Randomized Trial.

Chin SJ, Moore GA, Zhang M, Clarke HD, Spangehl MJ, Young SW. Chin SJ, et al. J Arthroplasty. 2018 Jul;33(7S):S13-S18. doi: 10.1016/j.arth.2018.03.013. Epub 2018 Mar 15. J Arthroplasty. 2018. PMID: 29655497 Clinical Trial.

CORR Insights(®): Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA.

Zalavras CG. Zalavras CG. Clin Orthop Relat Res. 2015 Nov;473(11):3585-7. doi: 10.1007/s11999-015-4521-5. Epub 2015 Aug 21. Clin Orthop Relat Res. 2015. PMID: 26293224 Free PMC article. No abstract available.

Intraosseous Regional Administration of Antibiotic Prophylaxis in Total Knee Arthroplasty.

Arthur JR, Bingham JS, Clarke HD, Spangehl MJ, Young SW. Arthur JR, et al. JBJS Essent Surg Tech. 2020 Dec 24;10(4):e20.00001. doi: 10.2106/JBJS.ST.20.00001. eCollection 2020 Oct-Dec. JBJS Essent Surg Tech. 2020. PMID: 34055474 Free PMC article.

The Mark Coventry Award: Higher tissue concentrations of vancomycin with low-dose intraosseous regional versus systemic prophylaxis in TKA: a randomized trial.

Young SW, Zhang M, Freeman JT, Mutu-Grigg J, Pavlou P, Moore GA. Young SW, et al. Clin Orthop Relat Res. 2014 Jan;472(1):57-65. doi: 10.1007/s11999-013-3038-z. Clin Orthop Relat Res. 2014. PMID: 23666589 Free PMC article. Clinical Trial.

Intraosseous Regional Administration of Antibiotic Prophylaxis for Total Knee Arthroplasty: A Systematic Review.

Miltenberg B, Ludwick L, Masood R, Menendez ME, Moverman MA, Pagani NR, Puzzitiello RN, Smith EL. Miltenberg B, et al. J Arthroplasty. 2023 Apr;38(4):769-774. doi: 10.1016/j.arth.2022.10.023. Epub 2022 Oct 22. J Arthroplasty. 2023. PMID: 36280158

Dual Antibiotic Prophylaxis in Total Knee Arthroplasty: Where Do We Stand?

Villa JM, Pannu TS, Riesgo AM, Patel PD, Mont MA, Higuera-Rueda CA. Villa JM, et al. J Knee Surg. 2020 Feb;33(2):100-105. doi: 10.1055/s-0039-1695742. Epub 2019 Aug 30. J Knee Surg. 2020. PMID: 31470454 Review.

Higher Tissue Concentrations of Vancomycin Achieved With Low-Dose Intraosseous Injection Versus Intravenous Despite Limited Tourniquet Duration in Primary Total Knee Arthroplasty: A Randomized Trial.

Spangehl MJ, Clarke HD, Moore GA, Zhang M, Probst NE, Young SW. Spangehl MJ, et al. J Arthroplasty. 2022 May;37(5):857-863. doi: 10.1016/j.arth.2022.01.057. Epub 2022 Jan 26. J Arthroplasty. 2022. PMID: 35091036 Clinical Trial.

Vascular graft infection by Staphylococcus aureus: efficacy of cefazolin, teicoplanin and vancomycin prophylaxis protocols in a rat model.

Atahan E, Gul M, Ergun Y, Eroglu E. Atahan E, et al. Eur J Vasc Endovasc Surg. 2007 Aug;34(2):182-7. doi: 10.1016/j.ejvs.2007.03.002. Epub 2007 May 4. Eur J Vasc Endovasc Surg. 2007. PMID: 17481929 Free article.

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