PubMed

Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.

Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD.

Environ Health Perspect. 2008 Sep;116(9):1154-61.PMID: 18795156 [PubMed - indexed for MEDLINE]Related articlesFree article

Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.

Wang XJ, Sun Z, Chen W, Eblin KE, Gandolfi JA, Zhang DD.

Toxicol Appl Pharmacol. 2007 Dec 1;225(2):206-13. Epub 2007 Aug 7.PMID: 17765279 [PubMed - indexed for MEDLINE]Related articlesFree article

Nrf2 protects against As(III)-induced damage in mouse liver and bladder.

Jiang T, Huang Z, Chan JY, Zhang DD.

Toxicol Appl Pharmacol. 2009 Oct 1;240(1):8-14. Epub 2009 Jun 16.PMID: 19538980 [PubMed - indexed for MEDLINE]Related articles

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction.

Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD.

Toxicol Appl Pharmacol. 2008 Aug 1;230(3):383-9. Epub 2008 Mar 12.PMID: 18417180 [PubMed - indexed for MEDLINE]Related articlesFree article

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.

Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S.

Antioxid Redox Signal. 2007 Nov;9(11):1963-70.PMID: 17822364 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells.

Papaiahgari S, Zhang Q, Kleeberger SR, Cho HY, Reddy SP.

Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):43-52.PMID: 16487036 [PubMed - indexed for MEDLINE]Related articles

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.

He X, Chen MG, Lin GX, Ma Q.

J Biol Chem. 2006 Aug 18;281(33):23620-31. Epub 2006 Jun 19.PMID: 16785233 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.

Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP.

Exp Cell Res. 2003 Nov 1;290(2):234-45.PMID: 14567983 [PubMed - indexed for MEDLINE]Related articles

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2.

Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD.

Carcinogenesis. 2008 Jun;29(6):1235-43. Epub 2008 Apr 15.PMID: 18413364 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity.

Gong P, Cederbaum AI.

J Biol Chem. 2006 May 26;281(21):14573-9. Epub 2006 Mar 21.PMID: 16551616 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of Nrf2 in defense against cadmium-induced oxidative stress.

He X, Chen MG, Ma Q.

Chem Res Toxicol. 2008 Jul;21(7):1375-83. Epub 2008 May 31.PMID: 18512965 [PubMed - indexed for MEDLINE]Related articles

Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling.

Zhu L, Pi J, Wachi S, Andersen ME, Wu R, Chen Y.

Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L469-77. Epub 2007 Dec 21.PMID: 18156441 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association.

He X, Lin GX, Chen MG, Zhang JX, Ma Q.

Toxicol Sci. 2007 Jul;98(1):298-309. Epub 2007 Apr 9.PMID: 17420218 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma.

Li N, Nel AE.

Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):88-98. Review.PMID: 16487041 [PubMed - indexed for MEDLINE]Related articles

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals.

Surh YJ, Kundu JK, Na HK.

Planta Med. 2008 Oct;74(13):1526-39. Epub 2008 Oct 20. Review.PMID: 18937164 [PubMed - indexed for MEDLINE]Related articles

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid.

Pi J, Zhang Q, Woods CG, Wong V, Collins S, Andersen ME.

Toxicol Appl Pharmacol. 2008 Feb 1;226(3):236-43. Epub 2007 Sep 26.PMID: 17980396 [PubMed - indexed for MEDLINE]Related articles

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.

Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S.

PLoS Med. 2006 Oct;3(10):e420.PMID: 17020408 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner.

Hwang YP, Kim HG, Han EH, Jeong HG.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):318-27. Epub 2008 May 2.PMID: 18554677 [PubMed - indexed for MEDLINE]Related articles

Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation.

Wruck CJ, Götz ME, Herdegen T, Varoga D, Brandenburg LO, Pufe T.

Mol Pharmacol. 2008 Jun;73(6):1785-95. Epub 2008 Mar 11.PMID: 18334601 [PubMed - indexed for MEDLINE]Related articlesFree article

Apomorphine protects against 6-hydroxydopamine-induced neuronal cell death through activation of the Nrf2-ARE pathway.

Hara H, Ohta M, Adachi T.

J Neurosci Res. 2006 Sep;84(4):860-6.PMID: 16802348 [PubMed - indexed for MEDLINE]Related articles