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    Results: 1 to 20 of 271

    1.

    Compound cytotoxicity profiling using quantitative high-throughput screening.

    Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP.

    Environ Health Perspect. 2008 Mar;116(3):284-91.PMID: 18335092 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

    O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR, Gao B, Kaludercic N, Angeline A, Bernardi P, Brain P, Hougham C.

    Arch Toxicol. 2006 Sep;80(9):580-604. Epub 2006 Apr 6.PMID: 16598496 [PubMed - indexed for MEDLINE]Related articles

    3.

    Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans.

    Abraham VC, Towne DL, Waring JF, Warrior U, Burns DJ.

    J Biomol Screen. 2008 Jul;13(6):527-37. Epub 2008 Jun 19.PMID: 18566484 [PubMed - indexed for MEDLINE]Related articles

    4.

    A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker.

    Cho MH, Niles A, Huang R, Inglese J, Austin CP, Riss T, Xia M.

    Toxicol In Vitro. 2008 Jun;22(4):1099-106. Epub 2008 Mar 4.PMID: 18400464 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening.

    Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP.

    Chem Res Toxicol. 2008 Mar;21(3):659-67. Epub 2008 Feb 19.PMID: 18281954 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity.

    Zhu H, Rusyn I, Richard A, Tropsha A.

    Environ Health Perspect. 2008 Apr;116(4):506-13.PMID: 18414635 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Liver cell models in in vitro toxicology.

    Guillouzo A.

    Environ Health Perspect. 1998 Apr;106 Suppl 2:511-32. Review.PMID: 9599700 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Quantitative structure-activity-activity and quantitative structure-activity investigations of human and rodent toxicity.

    Lessigiarska I, Worth AP, Netzeva TI, Dearden JC, Cronin MT.

    Chemosphere. 2006 Dec;65(10):1878-87. Epub 2006 May 22.PMID: 16714047 [PubMed - indexed for MEDLINE]Related articles

    9.

    Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers.

    Xu J, Ma M, Purcell WM.

    Toxicol Appl Pharmacol. 2003 Jun 1;189(2):100-11.PMID: 12781628 [PubMed - indexed for MEDLINE]Related articles

    10.

    Dose-Response Modeling of High-Throughput Screening Data.

    Parham F, Austin C, Southall N, Huang R, Tice R, Portier C.

    J Biomol Screen. 2009 Oct 14. [Epub ahead of print]PMID: 19828774 [PubMed - as supplied by publisher]Related articles

    11.

    Kinetic assessment of persistent halogenated xenobiotics in cell culture models: comparison of mono- and poly-halogenated compounds.

    Mühlebach SF, Karlaganis G, Honegger UE.

    Chemosphere. 2006 Mar;62(11):1838-45. Epub 2005 Oct 10.PMID: 16216307 [PubMed - indexed for MEDLINE]Related articles

    12.

    Subacute cytotoxicity testing with cultured human lung cells.

    Yang A, Cardona DL, Barile FA.

    Toxicol In Vitro. 2002 Feb;16(1):33-9.PMID: 11812637 [PubMed - indexed for MEDLINE]Related articles

    13.

    Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling.

    Valerio LG Jr, Arvidson KB, Chanderbhan RF, Contrera JF.

    Toxicol Appl Pharmacol. 2007 Jul 1;222(1):1-16. Epub 2007 Mar 24.PMID: 17482223 [PubMed - indexed for MEDLINE]Related articles

    14.

    Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potential.

    Evans SM, Casartelli A, Herreros E, Minnick DT, Day C, George E, Westmoreland C.

    Toxicol In Vitro. 2001 Aug-Oct;15(4-5):579-84.PMID: 11566594 [PubMed - indexed for MEDLINE]Related articles

    15.

    A strategy for primary high throughput cytotoxicity screening in pharmaceutical toxicology.

    Bugelski PJ, Atif U, Molton S, Toeg I, Lord PG, Morgan DG.

    Pharm Res. 2000 Oct;17(10):1265-72.PMID: 11145233 [PubMed - indexed for MEDLINE]Related articles

    16.

    Comparison of in vivo acute lethal potency and in vitro cytotoxicity of 48 chemicals.

    Shrivastava R, Delomenie C, Chevalier A, John G, Ekwall B, Walum E, Massingham R.

    Cell Biol Toxicol. 1992 Apr-Jun;8(2):157-70.PMID: 1422925 [PubMed - indexed for MEDLINE]Related articles

    17.

    In vitro cytotoxicity assessment.

    O'Brien P, Haskins JR.

    Methods Mol Biol. 2007;356:415-25.PMID: 16988420 [PubMed - indexed for MEDLINE]Related articles

    18.

    In vitro cytotoxicity assay to screen compounds for apoptosis-inducing potential on lymphocytes and neutrophils.

    Nagami K, Kawashima Y, Kuno H, Kemi M, Matsumoto H.

    J Toxicol Sci. 2002 Aug;27(3):191-203.PMID: 12238143 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Research perspectives for pre-screening alternatives to animal experimentation: on the relevance of cytotoxicity measurements, barrier passage determinations and high throughput screening in vitro to select potentially hazardous compounds in large sets of chemicals.

    Walum E, Hedander J, Garberg P.

    Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):393-7. Review.PMID: 15982691 [PubMed - indexed for MEDLINE]Related articles

    20.

    In vitro setting of dose-effect relationships of 32 metal compounds in the Balb/3T3 cell line, as a basis for predicting their carcinogenic potential.

    Mazzotti F, Sabbioni E, Ponti J, Ghiani M, Fortaner S, Rossi GL.

    Altern Lab Anim. 2002 Mar-Apr;30(2):209-17.PMID: 11971756 [PubMed - indexed for MEDLINE]Related articles

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