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Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.

Melnick RL, Thayer KA, Bucher JR.

Environ Health Perspect. 2008 Jan;116(1):130-5.PMID: 18197312 [PubMed - indexed for MEDLINE]Related articlesFree article

Are tumor incidence rates from chronic bioassays telling us what we need to know about carcinogens?

Gaylor DW.

Regul Toxicol Pharmacol. 2005 Mar;41(2):128-33. Epub 2004 Dec 19.PMID: 15698536 [PubMed - indexed for MEDLINE]Related articles

Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.

Rhomberg LR, Baetcke K, Blancato J, Bus J, Cohen S, Conolly R, Dixit R, Doe J, Ekelman K, Fenner-Crisp P, Harvey P, Hattis D, Jacobs A, Jacobson-Kram D, Lewandowski T, Liteplo R, Pelkonen O, Rice J, Somers D, Turturro A, West W, Olin S.

Crit Rev Toxicol. 2007;37(9):729-837. Review.PMID: 17957539 [PubMed - indexed for MEDLINE]Related articles

Hydroquinone: an evaluation of the human risks from its carcinogenic and mutagenic properties.

McGregor D.

Crit Rev Toxicol. 2007;37(10):887-914. Review.PMID: 18027166 [PubMed - indexed for MEDLINE]Related articles

Approaches to evaluating the toxicity and carcinogenicity of man-made fibers: summary of a workshop held November 11-13, 1991, Durham, North Carolina.

McClellan RO, Miller FJ, Hesterberg TW, Warheit DB, Bunn WB, Kane AB, Lippmann M, Mast RW, McConnell EE, Reinhardt CF.

Regul Toxicol Pharmacol. 1992 Dec;16(3):321-64. Review.PMID: 1293648 [PubMed - indexed for MEDLINE]Related articles

Dose-response analyses of experimental cancer data.

Melnick RL, Kohn MC.

Drug Metab Rev. 2000 May;32(2):193-209. Review.PMID: 10774775 [PubMed - indexed for MEDLINE]Related articles

Cancer dose--response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity.

Kirman CR, Gargas ML, Marsh GM, Strother DE, Klaunig JE, Collins JJ, Deskin R.

Regul Toxicol Pharmacol. 2005 Oct;43(1):85-103.PMID: 16099568 [PubMed - indexed for MEDLINE]Related articles

Absence of morphologic correlation between chemical toxicity and chemical carcinogenesis.

Huff J.

Environ Health Perspect. 1993 Dec;101 Suppl 5:45-53. Review.PMID: 8013424 [PubMed - indexed for MEDLINE]Related articlesFree article

Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling.

Valerio LG Jr, Arvidson KB, Chanderbhan RF, Contrera JF.

Toxicol Appl Pharmacol. 2007 Jul 1;222(1):1-16. Epub 2007 Mar 24.PMID: 17482223 [PubMed - indexed for MEDLINE]Related articles

Carcinogenesis bioassays: study duration and biological relevance.

Haseman J, Melnick R, Tomatis L, Huff J.

Food Chem Toxicol. 2001 Jul;39(7):739-44.PMID: 11397520 [PubMed - indexed for MEDLINE]Related articles

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature in 1993 to 1994 and by the National Toxicology Program in 1995 to 1996.

Gold LS, Manley NB, Slone TH, Rohrbach L.

Environ Health Perspect. 1999 Aug;107 Suppl 4:527-600.PMID: 10421768 [PubMed - indexed for MEDLINE]Related articlesFree article

Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. International Life Sciences Institute.

Robinson DE, MacDonald JS.

Toxicol Pathol. 2001;29 Suppl:13-9. Review.PMID: 11695549 [PubMed - indexed for MEDLINE]Related articles

An examination of the association between maximum-tolerated dose and carcinogenicity in 326 long-term studies in rats and mice.

Haseman JK, Seilkop SK.

Fundam Appl Toxicol. 1992 Aug;19(2):207-13.PMID: 1516777 [PubMed - indexed for MEDLINE]Related articles

Experimental design constraints on carcinogenic potency estimates.

Rieth JP, Starr TB.

J Toxicol Environ Health. 1989;27(3):287-96.PMID: 2754755 [PubMed - indexed for MEDLINE]Related articles

Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.

EFSA GMO Panel Working Group on Animal Feeding Trials.

Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13. Review.PMID: 18328408 [PubMed - indexed for MEDLINE]Related articles

Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans.

Knight A, Bailey J, Balcombe J.

Altern Lab Anim. 2006 Feb;34(1):29-38.PMID: 16522148 [PubMed - indexed for MEDLINE]Related articles

A search for chemical agents causing human cancer--lessons learned from rodent carcinogenicity studies.

Enomoto M.

J Toxicol Sci. 2000 Dec;25(5):381-92. Review.PMID: 11201169 [PubMed - indexed for MEDLINE]Related articles

Long-term chemical carcinogenesis bioassays predict human cancer hazards. Issues, controversies, and uncertainties.

Huff J.

Ann N Y Acad Sci. 1999;895:56-79.PMID: 10676409 [PubMed - indexed for MEDLINE]Related articles

Characterizing dose-response relationships in multiple cancer bioassays.

French JL, Williams PL.

Risk Anal. 2001 Feb;21(1):91-102.PMID: 11332555 [PubMed - indexed for MEDLINE]Related articles

Bioassays of shortened duration for drugs: statistical implications.

Kodell RL, Lin KK, Thorn BT, Chen JJ.

Toxicol Sci. 2000 Jun;55(2):415-32.PMID: 10828275 [PubMed - indexed for MEDLINE]Related articlesFree article