PubMed

Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.

Slotkin TA, MacKillop EA, Ryde IT, Seidler FJ.

Environ Health Perspect. 2007 Sep;115(9):1306-13.PMID: 17805420 [PubMed - indexed for MEDLINE]Related articlesFree article

Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.

Qiao D, Seidler FJ, Violin JD, Slotkin TA.

Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):183-90.PMID: 14741763 [PubMed - indexed for MEDLINE]Related articles

Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.

Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA.

Brain Res. 2001 Feb 9;891(1-2):54-68.PMID: 11164809 [PubMed - indexed for MEDLINE]Related articles

Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.

Qiao D, Seidler FJ, Slotkin TA.

Toxicol Appl Pharmacol. 2005 Aug 1;206(1):17-26. Epub 2004 Dec 24.PMID: 15963341 [PubMed - indexed for MEDLINE]Related articles

Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.

Song X, Violin JD, Seidler FJ, Slotkin TA.

Toxicol Appl Pharmacol. 1998 Jul;151(1):182-91.PMID: 9705902 [PubMed - indexed for MEDLINE]Related articles

Developmental cholinotoxicants: nicotine and chlorpyrifos.

Slotkin TA.

Environ Health Perspect. 1999 Feb;107 Suppl 1:71-80. Review.PMID: 10229709 [PubMed - indexed for MEDLINE]Related articlesFree article

Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases.

Wu YJ, Harp P, Yan XR, Pope CN.

Chem Biol Interact. 2003 Jan 6;142(3):255-68.PMID: 12453664 [PubMed - indexed for MEDLINE]Related articles

Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?

Crumpton TL, Seidler FJ, Slotkin TA.

Brain Res Dev Brain Res. 2000 Jun 30;121(2):189-95.PMID: 10876031 [PubMed - indexed for MEDLINE]Related articles

Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?

Meyer A, Seidler FJ, Cousins MM, Slotkin TA.

Environ Health Perspect. 2003 Dec;111(16):1871-6.PMID: 14644659 [PubMed - indexed for MEDLINE]Related articlesFree article

Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.

Slotkin TA, Seidler FJ, Wu C, MacKillop EA, Linden KG.

Environ Health Perspect. 2009 Mar;117(3):338-43. Epub 2008 Sep 9.PMID: 19337505 [PubMed - indexed for MEDLINE]Related articlesFree article

Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.

Lassiter TL, MacKillop EA, Ryde IT, Seidler FJ, Slotkin TA.

Brain Res Bull. 2009 Mar 30;78(6):313-22. Epub 2008 Oct 31.PMID: 18977280 [PubMed - indexed for MEDLINE]Related articles

Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.

Jameson RR, Seidler FJ, Slotkin TA.

Environ Health Perspect. 2007 Jan;115(1):65-70.PMID: 17366821 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.

Meyer A, Seidler FJ, Slotkin TA.

Environ Health Perspect. 2004 Feb;112(2):170-8.PMID: 14754571 [PubMed - indexed for MEDLINE]Related articlesFree article

Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.

Jameson RR, Seidler FJ, Qiao D, Slotkin TA.

Environ Health Perspect. 2006 May;114(5):667-72.PMID: 16675418 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel.

Slotkin TA, MacKillop EA, Ryde IT, Tate CA, Seidler FJ.

Environ Health Perspect. 2007 Jan;115(1):93-101.PMID: 17366826 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.

Song X, Seidler FJ, Saleh JL, Zhang J, Padilla S, Slotkin TA.

Toxicol Appl Pharmacol. 1997 Jul;145(1):158-74.PMID: 9221834 [PubMed - indexed for MEDLINE]Related articles

Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.

Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA.

Environ Health Perspect. 2004 Mar;112(3):295-301.PMID: 14998743 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.

Qiao D, Seidler FJ, Slotkin TA.

Environ Health Perspect. 2001 Sep;109(9):909-13.PMID: 11673119 [PubMed - indexed for MEDLINE]Related articlesFree article

Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.

Qiao D, Seidler FJ, Abreu-Villaça Y, Tate CA, Cousins MM, Slotkin TA.

Brain Res Dev Brain Res. 2004 Jan 31;148(1):43-52.PMID: 14757517 [PubMed - indexed for MEDLINE]Related articles

Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.

Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA.

Neurotoxicol Teratol. 2002 Nov-Dec;24(6):733-41.PMID: 12460655 [PubMed - indexed for MEDLINE]Related articles