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    Results: 1 to 20 of 701

    1.

    Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid.

    Paul DS, Harmon AW, Devesa V, Thomas DJ, Stýblo M.

    Environ Health Perspect. 2007 May;115(5):734-42. Epub 2007 Jan 29.PMID: 17520061 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes.

    Walton FS, Harmon AW, Paul DS, Drobná Z, Patel YM, Styblo M.

    Toxicol Appl Pharmacol. 2004 Aug 1;198(3):424-33.PMID: 15276423 [PubMed - indexed for MEDLINE]Related articles

    3.

    Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.

    Egawa K, Maegawa H, Shi K, Nakamura T, Obata T, Yoshizaki T, Morino K, Shimizu S, Nishio Y, Suzuki E, Kashiwagi A.

    J Biol Chem. 2002 Oct 11;277(41):38863-9. Epub 2002 Jul 29.PMID: 12147684 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.

    Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.

    Mol Endocrinol. 2001 Aug;15(8):1411-22.PMID: 11463863 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.

    Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS.

    J Biol Chem. 2008 Oct 10;283(41):27653-67. Epub 2008 Jul 31.PMID: 18669636 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.

    Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.

    J Biol Chem. 2005 Jun 10;280(23):22523-9. Epub 2005 Apr 11.PMID: 15824124 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

    Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A.

    Endocrinology. 2005 Mar;146(3):1328-37. Epub 2004 Dec 2.PMID: 15576463 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.

    Kachko I, Maissel A, Mazor L, Ben-Romano R, Watson RT, Hou JC, Pessin JE, Bashan N, Rudich A.

    Endocrinology. 2009 Jun;150(6):2618-26. Epub 2009 Jan 29.PMID: 19179444 [PubMed - indexed for MEDLINE]Related articles

    9.

    Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.

    Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y.

    Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1385-94.PMID: 12006370 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

    Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.

    Cell Signal. 2007 Dec;19(12):2444-57. Epub 2007 Aug 3.PMID: 17826953 [PubMed - indexed for MEDLINE]Related articles

    11.

    Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

    Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP.

    J Biol Chem. 2005 Jun 3;280(22):21622-8. Epub 2005 Mar 30.PMID: 15799971 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta.

    Ben-Romano R, Rudich A, Tirosh A, Potashnik R, Sasaoka T, Riesenberg K, Schlaeffer F, Bashan N.

    Diabetologia. 2004 Jun;47(6):1107-17. Epub 2004 May 28.PMID: 15168016 [PubMed - indexed for MEDLINE]Related articles

    13.

    Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes.

    Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, Miyake K, Sano W, Akimoto K, Ohno S, Kasuga M.

    Mol Cell Biol. 1998 Dec;18(12):6971-82.PMID: 9819385 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.

    Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M.

    J Biol Chem. 2003 Oct 3;278(40):38870-4. Epub 2003 Jul 10.PMID: 12855688 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes.

    Worrall DS, Olefsky JM.

    Mol Endocrinol. 2002 Feb;16(2):378-89.PMID: 11818508 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.

    Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH.

    Circulation. 2007 Oct 2;116(14):1585-95. Epub 2007 Sep 17.PMID: 17875968 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.

    Mahadev K, Wu X, Zilbering A, Zhu L, Lawrence JT, Goldstein BJ.

    J Biol Chem. 2001 Dec 28;276(52):48662-9. Epub 2001 Oct 11.PMID: 11598110 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.

    Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM.

    Mol Cell Biol. 2004 Oct;24(19):8778-89.PMID: 15367694 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism.

    Nakayama A, Hiromura M, Adachi Y, Sakurai H.

    J Biol Inorg Chem. 2008 Jun;13(5):675-84. Epub 2008 Feb 21.PMID: 18288506 [PubMed - indexed for MEDLINE]Related articles

    20.

    Mechanism of inhibition of insulin-stimulated glucose transport by 4-bromocrotonic acid in 3T3-L1 adipocytes.

    Chai SP, Fong JC.

    Cell Signal. 2003 Mar;15(3):269-77.PMID: 12531425 [PubMed - indexed for MEDLINE]Related articles

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