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    Results: 1 to 20 of 227

    1.

    Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.

    Keshava N, Caldwell JC.

    Environ Health Perspect. 2006 Sep;114(9):1464-70. Review.PMID: 16966106 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

    Caldwell JC, Keshava N.

    Environ Health Perspect. 2006 Sep;114(9):1457-63. Review.PMID: 16966105 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.

    Corton JC.

    Crit Rev Toxicol. 2008;38(10):857-75. Review.PMID: 18821149 [PubMed - indexed for MEDLINE]Related articles

    4.

    Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.

    Laughter AR, Dunn CS, Swanson CL, Howroyd P, Cattley RC, Corton JC.

    Toxicology. 2004 Oct 15;203(1-3):83-98.PMID: 15363585 [PubMed - indexed for MEDLINE]Related articles

    5.

    Key scientific issues in the health risk assessment of trichloroethylene.

    Chiu WA, Caldwell JC, Keshava N, Scott CS.

    Environ Health Perspect. 2006 Sep;114(9):1445-9. Review.PMID: 16966103 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Trichloroethylene cancer epidemiology: a consideration of select issues.

    Scott CS, Chiu WA.

    Environ Health Perspect. 2006 Sep;114(9):1471-8. Review.PMID: 16966107 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    PPARalpha agonist-induced rodent tumors: modes of action and human relevance.

    Klaunig JE, Babich MA, Baetcke KP, Cook JC, Corton JC, David RM, DeLuca JG, Lai DY, McKee RH, Peters JM, Roberts RA, Fenner-Crisp PA.

    Crit Rev Toxicol. 2003;33(6):655-780. Review.PMID: 14727734 [PubMed - indexed for MEDLINE]Related articles

    8.

    Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures.

    Caldwell JC, Keshava N, Evans MV.

    Environ Mol Mutagen. 2008 Mar;49(2):142-54. Review.PMID: 17973308 [PubMed - indexed for MEDLINE]Related articles

    9.

    trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.

    Maloney EK, Waxman DJ.

    Toxicol Appl Pharmacol. 1999 Dec 1;161(2):209-18.PMID: 10581215 [PubMed - indexed for MEDLINE]Related articles

    10.

    A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines.

    Doull J, Cattley R, Elcombe C, Lake BG, Swenberg J, Wilkinson C, Williams G, van Gemert M.

    Regul Toxicol Pharmacol. 1999 Jun;29(3):327-57. Review.PMID: 10388618 [PubMed - indexed for MEDLINE]Related articles

    11.

    Comments on article "Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene" by Clewell and Andersen.

    Caldwell JC, Evans MV, Marcus AH, Scott CS, Chiu WA, Okino MS, Preuss PW.

    Crit Rev Toxicol. 2006 Mar;36(3):291-4; discussion 295-8.PMID: 16686425 [PubMed - indexed for MEDLINE]Related articles

    12.

    Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.

    Clewell HJ, Andersen ME.

    Crit Rev Toxicol. 2004 Sep-Oct;34(5):385-445. Review.PMID: 15560567 [PubMed - indexed for MEDLINE]Related articles

    13.

    Issues in the pharmacokinetics of trichloroethylene and its metabolites.

    Chiu WA, Okino MS, Lipscomb JC, Evans MV.

    Environ Health Perspect. 2006 Sep;114(9):1450-6. Review.PMID: 16966104 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.

    Zhou YC, Waxman DJ.

    Environ Health Perspect. 1998 Aug;106 Suppl 4:983-8.PMID: 9703482 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?

    Melnick RL.

    Environ Health Perspect. 2001 May;109(5):437-42. Review.PMID: 11401753 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Rodent carcinogenicity of peroxisome proliferators and issues on human relevance.

    Lai DY.

    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2004 May;22(1):37-55. Review.PMID: 15845221 [PubMed - indexed for MEDLINE]Related articles

    17.

    Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.

    Moore MM, Harrington-Brock K.

    Environ Health Perspect. 2000 May;108 Suppl 2:215-23. Review.PMID: 10807553 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation.

    Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ.

    Mol Cell Biol. 2007 Jun;27(12):4238-47. Epub 2007 Apr 16.PMID: 17438130 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver.

    Lapinskas PJ, Brown S, Leesnitzer LM, Blanchard S, Swanson C, Cattley RC, Corton JC.

    Toxicology. 2005 Feb 1;207(1):149-63.PMID: 15590130 [PubMed - indexed for MEDLINE]Related articles

    20.

    Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.

    Morimura K, Cheung C, Ward JM, Reddy JK, Gonzalez FJ.

    Carcinogenesis. 2006 May;27(5):1074-80. Epub 2005 Dec 24.PMID: 16377806 [PubMed - indexed for MEDLINE]Related articlesFree article

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