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Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

Caldwell JC, Keshava N.

Environ Health Perspect. 2006 Sep;114(9):1457-63. Review.PMID: 16966105 [PubMed - indexed for MEDLINE]Related articlesFree article

Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.

Keshava N, Caldwell JC.

Environ Health Perspect. 2006 Sep;114(9):1464-70. Review.PMID: 16966106 [PubMed - indexed for MEDLINE]Related articlesFree article

Trichloroethylene cancer epidemiology: a consideration of select issues.

Scott CS, Chiu WA.

Environ Health Perspect. 2006 Sep;114(9):1471-8. Review.PMID: 16966107 [PubMed - indexed for MEDLINE]Related articlesFree article

Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures.

Caldwell JC, Keshava N, Evans MV.

Environ Mol Mutagen. 2008 Mar;49(2):142-54. Review.PMID: 17973308 [PubMed - indexed for MEDLINE]Related articles

Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.

Moore MM, Harrington-Brock K.

Environ Health Perspect. 2000 May;108 Suppl 2:215-23. Review.PMID: 10807553 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.

Corton JC.

Crit Rev Toxicol. 2008;38(10):857-75. Review.PMID: 18821149 [PubMed - indexed for MEDLINE]Related articles

Issues in the pharmacokinetics of trichloroethylene and its metabolites.

Chiu WA, Okino MS, Lipscomb JC, Evans MV.

Environ Health Perspect. 2006 Sep;114(9):1450-6. Review.PMID: 16966104 [PubMed - indexed for MEDLINE]Related articlesFree article

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.

Clewell HJ, Andersen ME.

Crit Rev Toxicol. 2004 Sep-Oct;34(5):385-445. Review.PMID: 15560567 [PubMed - indexed for MEDLINE]Related articles

Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.

Bull RJ.

Environ Health Perspect. 2000 May;108 Suppl 2:241-59. Review.PMID: 10807555 [PubMed - indexed for MEDLINE]Related articlesFree article

Key scientific issues in the health risk assessment of trichloroethylene.

Chiu WA, Caldwell JC, Keshava N, Scott CS.

Environ Health Perspect. 2006 Sep;114(9):1445-9. Review.PMID: 16966103 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Kim S, Kim D, Pollack GM, Collins LB, Rusyn I.

Toxicol Appl Pharmacol. 2009 Jul 1;238(1):90-9. Epub 2009 May 3.PMID: 19409406 [PubMed - indexed for MEDLINE]Related articles

A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice.

Abbas R, Fisher JW.

Toxicol Appl Pharmacol. 1997 Nov;147(1):15-30.PMID: 9356303 [PubMed - indexed for MEDLINE]Related articles

A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.

Delinsky AD, Bruckner JV, Bartlett MG.

Biomed Chromatogr. 2005 Oct;19(8):617-39. Review.PMID: 15828053 [PubMed - indexed for MEDLINE]Related articles

Kinetics of chloral hydrate and its metabolites in male human volunteers.

Merdink JL, Robison LM, Stevens DK, Hu M, Parker JC, Bull RJ.

Toxicology. 2008 Mar 12;245(1-2):130-40. Epub 2007 Dec 28.PMID: 18243465 [PubMed - indexed for MEDLINE]Related articles

Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.

Greenberg MS, Burton GA, Fisher JW.

Toxicol Appl Pharmacol. 1999 Feb 1;154(3):264-78.PMID: 9931286 [PubMed - indexed for MEDLINE]Related articles

Comments on article "Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene" by Clewell and Andersen.

Caldwell JC, Evans MV, Marcus AH, Scott CS, Chiu WA, Okino MS, Preuss PW.

Crit Rev Toxicol. 2006 Mar;36(3):291-4; discussion 295-8.PMID: 16686425 [PubMed - indexed for MEDLINE]Related articles

Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Kim S, Collins LB, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I.

Toxicology. 2009 Aug 21;262(3):230-8. Epub 2009 Jun 21.PMID: 19549554 [PubMed - indexed for MEDLINE]Related articles

Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate.

Larson JL, Bull RJ.

Toxicol Appl Pharmacol. 1992 Aug;115(2):278-85.PMID: 1641861 [PubMed - indexed for MEDLINE]Related articles

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

Bull RJ, Orner GA, Cheng RS, Stillwell L, Stauber AJ, Sasser LB, Lingohr MK, Thrall BD.

Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65.PMID: 12127263 [PubMed - indexed for MEDLINE]Related articles

Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol.

Bronley-DeLancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG.

Environ Health Perspect. 2006 Aug;114(8):1237-42.PMID: 16882532 [PubMed - indexed for MEDLINE]Related articlesFree article