PubMed

Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.

Jameson RR, Seidler FJ, Qiao D, Slotkin TA.

Environ Health Perspect. 2006 May;114(5):667-72.PMID: 16675418 [PubMed - indexed for MEDLINE]Related articlesFree article

Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.

Slotkin TA, Seidler FJ.

Brain Res Bull. 2009 Aug 28;80(1-2):17-21. Epub 2009 Jun 17.PMID: 19539729 [PubMed - indexed for MEDLINE]Related articles

Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.

Song X, Violin JD, Seidler FJ, Slotkin TA.

Toxicol Appl Pharmacol. 1998 Jul;151(1):182-91.PMID: 9705902 [PubMed - indexed for MEDLINE]Related articles

Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.

Qiao D, Seidler FJ, Abreu-Villaça Y, Tate CA, Cousins MM, Slotkin TA.

Brain Res Dev Brain Res. 2004 Jan 31;148(1):43-52.PMID: 14757517 [PubMed - indexed for MEDLINE]Related articles

Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?

Das KP, Barone S Jr.

Toxicol Appl Pharmacol. 1999 Nov 1;160(3):217-30.PMID: 10544056 [PubMed - indexed for MEDLINE]Related articles

Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure.

Slotkin TA, Cousins MM, Tate CA, Seidler FJ.

Brain Res. 2001 Jun 1;902(2):229-43.PMID: 11384617 [PubMed - indexed for MEDLINE]Related articles

Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?

Crumpton TL, Seidler FJ, Slotkin TA.

Brain Res Dev Brain Res. 2000 Jun 30;121(2):189-95.PMID: 10876031 [PubMed - indexed for MEDLINE]Related articles

Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.

Dam K, Garcia SJ, Seidler FJ, Slotkin TA.

Brain Res Dev Brain Res. 1999 Aug 5;116(1):9-20.PMID: 10446342 [PubMed - indexed for MEDLINE]Related articles

Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.

Slotkin TA, MacKillop EA, Ryde IT, Seidler FJ.

Environ Health Perspect. 2007 Sep;115(9):1306-13.PMID: 17805420 [PubMed - indexed for MEDLINE]Related articlesFree article

Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.

Lassiter TL, MacKillop EA, Ryde IT, Seidler FJ, Slotkin TA.

Brain Res Bull. 2009 Mar 30;78(6):313-22. Epub 2008 Oct 31.PMID: 18977280 [PubMed - indexed for MEDLINE]Related articles

Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.

Jameson RR, Seidler FJ, Slotkin TA.

Environ Health Perspect. 2007 Jan;115(1):65-70.PMID: 17366821 [PubMed - indexed for MEDLINE]Related articlesFree article

Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures.

Monnet-Tschudi F, Zurich MG, Schilter B, Costa LG, Honegger P.

Toxicol Appl Pharmacol. 2000 Jun 15;165(3):175-83.PMID: 10873710 [PubMed - indexed for MEDLINE]Related articles

Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.

Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA.

Brain Res. 2001 Feb 9;891(1-2):54-68.PMID: 11164809 [PubMed - indexed for MEDLINE]Related articles

Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.

Qiao D, Seidler FJ, Violin JD, Slotkin TA.

Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):183-90.PMID: 14741763 [PubMed - indexed for MEDLINE]Related articles

Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by retinoic acid: increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase activity.

Matsuoka I, Mizuno N, Kurihara K.

Brain Res. 1989 Nov 13;502(1):53-60.PMID: 2573410 [PubMed - indexed for MEDLINE]Related articles

Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation.

Crumpton TL, Seidler FJ, Slotkin TA.

Brain Res. 2000 Feb 28;857(1-2):87-98.PMID: 10700556 [PubMed - indexed for MEDLINE]Related articles

Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein.

Garcia SJ, Seidler FJ, Qiao D, Slotkin TA.

Brain Res Dev Brain Res. 2002 Feb 28;133(2):151-61.PMID: 11882345 [PubMed - indexed for MEDLINE]Related articles

Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.

Slotkin TA, Seidler FJ, Fumagalli F.

Brain Res Bull. 2008 Jul 1;76(4):424-38. Epub 2008 Feb 1.PMID: 18502319 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of tyrosine hydroxylase and downregulation of choline acetyltransferase in lead-exposed PC12 cells: the role of PKC activation.

Tian X, Sun X, Suszkiw JB.

Toxicol Appl Pharmacol. 2000 Sep 15;167(3):246-52.PMID: 10986016 [PubMed - indexed for MEDLINE]Related articles

Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability.

Jameson RR, Seidler FJ, Qiao D, Slotkin TA.

Neuropsychopharmacology. 2006 Aug;31(8):1647-58. Epub 2005 Nov 30.PMID: 16319912 [PubMed - indexed for MEDLINE]Related articlesFree article