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    Results: 1 to 20 of 103

    1.

    Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

    Tabb MM, Kholodovych V, Grün F, Zhou C, Welsh WJ, Blumberg B.

    Environ Health Perspect. 2004 Feb;112(2):163-9.PMID: 14754570 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.

    Zhou C, Tabb MM, Nelson EL, Grün F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B.

    J Clin Invest. 2006 Aug;116(8):2280-2289.PMID: 16841097 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

    Zhou C, Verma S, Blumberg B.

    Nucl Recept Signal. 2009;7:e001. Epub 2009 Jan 16. Review.PMID: 19240808 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

    Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA.

    Mol Pharmacol. 2002 Sep;62(3):638-46.PMID: 12181440 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription.

    Takeshita A, Koibuchi N, Oka J, Taguchi M, Shishiba Y, Ozawa Y.

    Eur J Endocrinol. 2001 Oct;145(4):513-7.PMID: 11581012 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.

    Schuetz EG, Brimer C, Schuetz JD.

    Mol Pharmacol. 1998 Dec;54(6):1113-7.PMID: 9855641 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor.

    Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E, Robertson LW.

    Environ Health Perspect. 2005 Jan;113(1):83-7.PMID: 15626652 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

    Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT.

    Mol Endocrinol. 2000 Jan;14(1):27-39.PMID: 10628745 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

    Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA.

    J Biol Chem. 2000 May 19;275(20):15122-7.PMID: 10748001 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Humanized xenobiotic response in mice expressing nuclear receptor SXR.

    Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RM.

    Nature. 2000 Jul 27;406(6794):435-9.PMID: 10935643 [PubMed - indexed for MEDLINE]Related articles

    11.

    Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor.

    Rosenfeld JM, Vargas R Jr, Xie W, Evans RM.

    Mol Endocrinol. 2003 Jul;17(7):1268-82. Epub 2003 Mar 27.PMID: 12663745 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

    Rushmore TH, Kong AN.

    Curr Drug Metab. 2002 Oct;3(5):481-90. Review.PMID: 12369894 [PubMed - indexed for MEDLINE]Related articles

    13.

    Polychlorinated biphenyls affect gene expression in the rabbit preimplantation embryo.

    Kietz S, Fischer B.

    Mol Reprod Dev. 2003 Mar;64(3):251-60.PMID: 12548657 [PubMed - indexed for MEDLINE]Related articles

    14.

    Induction of phase I, II and III drug metabolism/transport by xenobiotics.

    Xu C, Li CY, Kong AN.

    Arch Pharm Res. 2005 Mar;28(3):249-68. Review.PMID: 15832810 [PubMed - indexed for MEDLINE]Related articles

    15.

    Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells.

    Machala M, Bláha L, Lehmler HJ, Plísková M, Májková Z, Kapplová P, Sovadinová I, Vondrácek J, Malmberg T, Robertson LW.

    Chem Res Toxicol. 2004 Mar;17(3):340-7.PMID: 15025504 [PubMed - indexed for MEDLINE]Related articles

    16.

    Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).

    Jacobs MN, Nolan GT, Hood SR.

    Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33.PMID: 15885729 [PubMed - indexed for MEDLINE]Related articles

    17.

    Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.

    Zhang H, LeCulyse E, Liu L, Hu M, Matoney L, Zhu W, Yan B.

    Arch Biochem Biophys. 1999 Aug 1;368(1):14-22.PMID: 10415106 [PubMed - indexed for MEDLINE]Related articles

    18.

    The nuclear pregnane X receptor regulates xenobiotic detoxification.

    Kliewer SA.

    J Nutr. 2003 Jul;133(7 Suppl):2444S-2447S. Review.PMID: 12840222 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

    Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM.

    Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80.PMID: 11248086 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.

    Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B.

    Mol Endocrinol. 2007 Sep;21(9):2099-111. Epub 2007 Jun 26.PMID: 17595319 [PubMed - indexed for MEDLINE]Related articlesFree article

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