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    Results: 1 to 20 of 149

    1.

    Chiral discrimination in platinum anticancer drugs.

    Benedetti M, Malina J, Kasparkova J, Brabec V, Natile G.

    Environ Health Perspect. 2002 Oct;110 Suppl 5:779-82. Review.PMID: 12426131 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.

    Kasparkova J, Novakova O, Farrell N, Brabec V.

    Biochemistry. 2003 Jan 28;42(3):792-800.PMID: 12534292 [PubMed - indexed for MEDLINE]Related articles

    3.

    Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.

    Najajreh Y, Kasparkova J, Marini V, Gibson D, Brabec V.

    J Biol Inorg Chem. 2005 Nov;10(7):722-31. Epub 2005 Nov 8.PMID: 16208494 [PubMed - indexed for MEDLINE]Related articles

    4.

    DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.

    Novakova O, Kasparkova J, Malina J, Natile G, Brabec V.

    Nucleic Acids Res. 2003 Nov 15;31(22):6450-60.PMID: 14602903 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.

    Kasparkova J, Vojtiskova M, Natile G, Brabec V.

    Chemistry. 2008;14(4):1330-41.PMID: 18022972 [PubMed - indexed for MEDLINE]Related articles

    6.

    Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites.

    Qu Y, Scarsdale NJ, Tran MC, Farrell NP.

    J Biol Inorg Chem. 2003 Jan;8(1-2):19-28. Epub 2002 Jul 31.PMID: 12459895 [PubMed - indexed for MEDLINE]Related articles

    7.

    DNA interactions of new antitumor aminophosphine platinum(II) complexes.

    Neplechová K, Kaspárková J, Vrána O, Nováková O, Habtemariam A, Watchman B, Sadler PJ, Brabec V.

    Mol Pharmacol. 1999 Jul;56(1):20-30.PMID: 10385680 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking.

    Kaspárková J, Nováková O, Vrána O, Farrell N, Brabec V.

    Biochemistry. 1999 Aug 24;38(34):10997-1005.PMID: 10460154 [PubMed - indexed for MEDLINE]Related articles

    9.

    Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action.

    Kasparkova J, Novakova O, Marini V, Najajreh Y, Gibson D, Perez JM, Brabec V.

    J Biol Chem. 2003 Nov 28;278(48):47516-25. Epub 2003 Sep 10.PMID: 12970368 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Cellular pharmacology of polynuclear platinum anti-cancer agents.

    Roberts JD, Peroutka J, Farrell N.

    J Inorg Biochem. 1999 Oct;77(1-2):51-7.PMID: 10626354 [PubMed - indexed for MEDLINE]Related articles

    11.

    A rare example of three abundant conformers in one retro model of the cisplatin-DNA d(GpG) intrastrand cross link. Unambiguous evidence that guanine O6 to carrier amine ligand hydrogen bonding is not important. possible effect of the Lippard base pair step adjacent to the lesion on carrier ligand hydrogen bonding in DNA adducts.

    Sullivan ST, Ciccarese A, Fanizzi FP, Marzilli LG.

    J Am Chem Soc. 2001 Sep 26;123(38):9345-55.PMID: 11562217 [PubMed - indexed for MEDLINE]Related articles

    12.

    DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.

    Kasparkova J, Marini V, Najajreh Y, Gibson D, Brabec V.

    Biochemistry. 2003 May 27;42(20):6321-32.PMID: 12755637 [PubMed - indexed for MEDLINE]Related articles

    13.

    Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent.

    Delalande O, Malina J, Brabec V, Kozelka J.

    Biophys J. 2005 Jun;88(6):4159-69. Epub 2005 Apr 1.PMID: 15805172 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.

    Malina J, Hofr C, Maresca L, Natile G, Brabec V.

    Biophys J. 2000 Apr;78(4):2008-21.PMID: 10733979 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.

    Brabec V, Neplechova K, Kasparkova J, Farrell N.

    J Biol Inorg Chem. 2000 Jun;5(3):364-8.PMID: 10907747 [PubMed - indexed for MEDLINE]Related articles

    16.

    Nonclassical platinum antitumor agents: perspectives for design and development of new drugs complementary to cisplatin.

    Farrell N.

    Cancer Invest. 1993;11(5):578-89. Review.PMID: 8402226 [PubMed - indexed for MEDLINE]Related articles

    17.

    Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.

    Kasparkova J, Farrell N, Brabec V.

    J Biol Chem. 2000 May 26;275(21):15789-98.PMID: 10747955 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands.

    de Mier-Vinué J, Gay M, Montaña AM, Sáez RI, Moreno V, Kasparkova J, Vrana O, Heringova P, Brabec V, Boccarelli A, Coluccia M, Natile G.

    J Med Chem. 2008 Feb 14;51(3):424-31. Epub 2008 Jan 16.PMID: 18197615 [PubMed - indexed for MEDLINE]Related articles

    19.

    Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.

    Kasparkova J, Novakova O, Najajreh Y, Gibson D, Perez JM, Brabec V.

    Chem Res Toxicol. 2003 Nov;16(11):1424-32.PMID: 14615968 [PubMed - indexed for MEDLINE]Related articles

    20.

    Trans-platinum complexes in cancer therapy.

    Coluccia M, Natile G.

    Anticancer Agents Med Chem. 2007 Jan;7(1):111-23. Review.PMID: 17266508 [PubMed - indexed for MEDLINE]Related articles

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