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Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.

Luu HM, Hutter JC.

Environ Health Perspect. 2001 Nov;109(11):1095-101.PMID: 11712992 [PubMed - indexed for MEDLINE]Related articlesFree article

Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models.

Sarangapani R, Teeguarden J, Andersen ME, Reitz RH, Plotzke KP.

Toxicol Sci. 2003 Jan;71(1):41-52.PMID: 12520074 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.

Andersen ME, Sarangapani R, Reitz RH, Gallavan RH, Dobrev ID, Plotzke KP.

Toxicol Sci. 2001 Apr;60(2):214-31.PMID: 11248133 [PubMed - indexed for MEDLINE]Related articlesFree article

Bioavailability of D4 after inhalation and implantation exposure to silicones.

Meeks RG.

Environ Health Perspect. 2002 Aug;110(8):A442-3; author reply A445-8. No abstract available. PMID: 12153770 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.

Reddy MB, Dobrev ID, McNett DA, Tobin JM, Utell MJ, Morrow PE, Domoradzki JY, Plotzke KP, Andersen ME.

Toxicol Sci. 2008 Oct;105(2):275-85. Epub 2008 Jun 26.PMID: 18583370 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.

Reddy MB, Andersen ME, Morrow PE, Dobrev ID, Varaprath S, Plotzke KP, Utell MJ.

Toxicol Sci. 2003 Mar;72(1):3-18.PMID: 12604830 [PubMed - indexed for MEDLINE]Related articlesFree article

Disposition of radioactivity in fischer 344 rats after single and multiple inhalation exposure to [(14)C]Octamethylcyclotetrasiloxane ([(14)C]D(4)).

Plotzke KP, Crofoot SD, Ferdinandi ES, Beattie JG, Reitz RH, McNett DA, Meeks RG.

Drug Metab Dispos. 2000 Feb;28(2):192-204.PMID: 10640518 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.

Sarangapani R, Teeguarden J, Plotzke KP, McKim JM Jr, Andersen ME.

Toxicol Sci. 2002 Jun;67(2):159-72.PMID: 12011475 [PubMed - indexed for MEDLINE]Related articlesFree article

Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?

Andersen ME, Reddy MB, Plotzke KP.

Toxicol Lett. 2008 Jun 30;179(2):85-92. Epub 2008 Apr 22.PMID: 18513896 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure.

Nong A, Teeguarden JG, Clewell HJ 3rd, Dorman DC, Andersen ME.

J Toxicol Environ Health A. 2008;71(7):413-26.PMID: 18306088 [PubMed - indexed for MEDLINE]Related articles

Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.

Dobrev ID, Nong A, Liao KH, Reddy MB, Plotzke KP, Andersen ME.

Inhal Toxicol. 2008 Feb;20(4):361-73.PMID: 18302045 [PubMed - indexed for MEDLINE]Related articles

Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats.

Burns-Naas LA, Meeks RG, Kolesar GB, Mast RW, Elwell MR, Hardisty JF, Thevenaz P.

Int J Toxicol. 2002 Jan-Feb;21(1):39-53.PMID: 11936898 [PubMed - indexed for MEDLINE]Related articles

Closed-chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat.

Dobrev ID, Reddy MB, Plotzke KP, Varaprath S, McNett DA, Durham J, Andersen ME.

Inhal Toxicol. 2003 May;15(6):589-617.PMID: 12692732 [PubMed - indexed for MEDLINE]Related articles

PBPK models in risk assessment--A focus on chloroprene.

DeWoskin RS.

Chem Biol Interact. 2007 Mar 20;166(1-3):352-9. Epub 2007 Feb 8.PMID: 17324392 [PubMed - indexed for MEDLINE]Related articles

A physiologically based pharmacokinetic model for 2,4-toluenediamine leached from polyurethane foam-covered breast implants.

Luu HM, Hutter JC, Bushar HF.

Environ Health Perspect. 1998 Jul;106(7):393-400.PMID: 9637796 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of repeated inhalation on the distribution of uranium in rats.

Monleau M, Blanchardon E, Claraz M, Paquet F, Chazel V.

J Toxicol Environ Health A. 2006 Sep;69(17):1629-49.PMID: 16854790 [PubMed - indexed for MEDLINE]Related articles

A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation.

Siddiqui WH, Stump DG, Plotzke KP, Holson JF, Meeks RG.

Reprod Toxicol. 2007 Feb;23(2):202-15. Epub 2006 Dec 1.PMID: 17223010 [PubMed - indexed for MEDLINE]Related articles

A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes of soman in multiple species.

Sweeney RE, Langenberg JP, Maxwell DM.

Arch Toxicol. 2006 Nov;80(11):719-31. Epub 2006 May 23.PMID: 16718492 [PubMed - indexed for MEDLINE]Related articles

Physiologically based pharmacokinetic (PBPK) modeling of everolimus (RAD001) in rats involving non-linear tissue uptake.

Laplanche R, Meno-Tetang GM, Kawai R.

J Pharmacokinet Pharmacodyn. 2007 Jun;34(3):373-400. Epub 2007 Mar 13.PMID: 17431753 [PubMed - indexed for MEDLINE]Related articles

Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).

Reddy MB, Looney RJ, Utell MJ, Plotzke KP, Andersen ME.

Toxicol Sci. 2007 Oct;99(2):422-31. Epub 2007 Jul 14.PMID: 17630416 [PubMed - indexed for MEDLINE]Related articlesFree article