PubMed

Dose-response analyses of the carcinogenic effects of trichloroethylene in experimental animals.

Rhomberg LR.

Environ Health Perspect. 2000 May;108 Suppl 2:343-58. Review.PMID: 10807564 [PubMed - indexed for MEDLINE]Related articlesFree article

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.

Clewell HJ, Andersen ME.

Crit Rev Toxicol. 2004 Sep-Oct;34(5):385-445. Review.PMID: 15560567 [PubMed - indexed for MEDLINE]Related articles

Trichloroethylene and cancer: epidemiologic evidence

Scott CS, Cogliano VJ.

Environ Health Perspect. 2000 May;108 Suppl 2:159-60.PMID: 10807549 [PubMed - as supplied by publisher]Related articles

Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic end points.

Bogen KT, Gold LS.

Regul Toxicol Pharmacol. 1997 Feb;25(1):26-42. Review.PMID: 9056499 [PubMed - indexed for MEDLINE]Related articles

A trichloroethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling.

Cronin WJ 4th, Oswald EJ, Shelley ML, Fisher JW, Flemming CD.

Risk Anal. 1995 Oct;15(5):555-65.PMID: 7501875 [PubMed - indexed for MEDLINE]Related articles

Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models.

Fisher JW, Allen BC.

Risk Anal. 1993 Feb;13(1):87-95.PMID: 8451463 [PubMed - indexed for MEDLINE]Related articles

Biologically based dose-response model for liver tumors induced by trichloroethylene.

Chen CW.

Environ Health Perspect. 2000 May;108 Suppl 2:335-42.PMID: 10807563 [PubMed - indexed for MEDLINE]Related articlesFree article

Chloroform mode of action: implications for cancer risk assessment.

Golden RJ, Holm SE, Robinson DE, Julkunen PH, Reese EA.

Regul Toxicol Pharmacol. 1997 Oct;26(2):142-55. Review.PMID: 9356278 [PubMed - indexed for MEDLINE]Related articles

Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.

Bull RJ.

Environ Health Perspect. 2000 May;108 Suppl 2:241-59. Review.PMID: 10807555 [PubMed - indexed for MEDLINE]Related articlesFree article

NTP Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

National Toxicology Program.

Natl Toxicol Program Tech Rep Ser. 1990 May;243:1-174.PMID: 12750750 [PubMed - as supplied by publisher]Related articles

NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.

Beland FA.

Toxic Rep Ser. 1999 Aug;(59):1-66, A1-E7.PMID: 11803702 [PubMed - indexed for MEDLINE]Related articles

Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly.

Evans MV, Chiu WA, Okino MS, Caldwell JC.

Toxicol Appl Pharmacol. 2009 May 1;236(3):329-40. Epub 2009 Feb 26.PMID: 19249323 [PubMed - indexed for MEDLINE]Related articles

Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.

Moore MM, Harrington-Brock K.

Environ Health Perspect. 2000 May;108 Suppl 2:215-23. Review.PMID: 10807553 [PubMed - indexed for MEDLINE]Related articlesFree article

Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate.

Larson JL, Bull RJ.

Toxicol Appl Pharmacol. 1992 Aug;115(2):278-85.PMID: 1641861 [PubMed - indexed for MEDLINE]Related articles

Improving cancer dose-response characterization by using physiologically based pharmacokinetic modeling: an analysis of pooled data for acrylonitrile-induced brain tumors to assess cancer potency in the rat.

Kirman CR, Hays SM, Kedderis GL, Gargas ML, Strother DE.

Risk Anal. 2000 Feb;20(1):135-51.PMID: 10795346 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Kim S, Kim D, Pollack GM, Collins LB, Rusyn I.

Toxicol Appl Pharmacol. 2009 Jul 1;238(1):90-9. Epub 2009 May 3.PMID: 19409406 [PubMed - indexed for MEDLINE]Related articles

Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

Caldwell JC, Keshava N.

Environ Health Perspect. 2006 Sep;114(9):1457-63. Review.PMID: 16966105 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

Clewell HJ 3rd, Gentry PR, Covington TR, Gearhart JM.

Environ Health Perspect. 2000 May;108 Suppl 2:283-305. Review.PMID: 10807559 [PubMed - indexed for MEDLINE]Related articlesFree article

NTP Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

National Toxicology Program.

Natl Toxicol Program Tech Rep Ser. 1998 Sep;467:1-379.PMID: 12579206 [PubMed - as supplied by publisher]Related articlesFree article

Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer.

Barton HA, Bull R, Schultz I, Andersen ME.

Toxicol Lett. 1999 May 20;106(1):9-21.PMID: 10378446 [PubMed - indexed for MEDLINE]Related articles