PubMed

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment.

Barton HA, Clewell HJ 3rd.

Environ Health Perspect. 2000 May;108 Suppl 2:323-34. Review.PMID: 10807562 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluating human variability in chemical risk assessment: hazard identification and dose-response assessment for noncancer oral toxicity of trichloroethylene.

Barton HA, Flemming CD, Lipscomb JC.

Toxicology. 1996 Jul 17;111(1-3):271-87. Review.PMID: 8711742 [PubMed - indexed for MEDLINE]Related articles

Using physiologically-based pharmacokinetic modeling to address nonlinear kinetics and changes in rodent physiology and metabolism due to aging and adaptation in deriving reference values for propylene glycol methyl ether and propylene glycol methyl ether acetate.

Kirman CR, Sweeney LM, Corley R, Gargas ML.

Risk Anal. 2005 Apr;25(2):271-84.PMID: 15876203 [PubMed - indexed for MEDLINE]Related articles

Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP).

Jarabek AM, Asgharian B, Miller FJ.

Inhal Toxicol. 2005 Jun-Jul;17(7-8):317-34.PMID: 16020031 [PubMed - indexed for MEDLINE]Related articles

Investigation of the potential impact of benchmark dose and pharmacokinetic modeling in noncancer risk assessment.

Clewell HJ 3rd, Gentry PR, Gearhart JM.

J Toxicol Environ Health. 1997 Dec 26;52(6):475-515.PMID: 9397182 [PubMed - indexed for MEDLINE]Related articles

Alternatives for a risk assessment on chronic noncancer effects from oral exposure to trichloroethylene.

Barton HA, Das S.

Regul Toxicol Pharmacol. 1996 Dec;24(3):269-85.PMID: 8975757 [PubMed - indexed for MEDLINE]Related articles

Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose.

Simmons JE, Evans MV, Boyes WK.

J Toxicol Environ Health A. 2005 Jun 11-25;68(11-12):927-50.PMID: 16020185 [PubMed - indexed for MEDLINE]Related articles

Determination of a site-specific reference dose for methylmercury for fish-eating populations.

Shipp AM, Gentry PR, Lawrence G, Van Landingham C, Covington T, Clewell HJ, Gribben K, Crump K.

Toxicol Ind Health. 2000 Nov;16(9-10):335-438. Review.PMID: 11762928 [PubMed - indexed for MEDLINE]Related articles

A trichloroethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling.

Cronin WJ 4th, Oswald EJ, Shelley ML, Fisher JW, Flemming CD.

Risk Anal. 1995 Oct;15(5):555-65.PMID: 7501875 [PubMed - indexed for MEDLINE]Related articles

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

Clewell HJ 3rd, Gentry PR, Covington TR, Gearhart JM.

Environ Health Perspect. 2000 May;108 Suppl 2:283-305. Review.PMID: 10807559 [PubMed - indexed for MEDLINE]Related articlesFree article

Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic end points.

Bogen KT, Gold LS.

Regul Toxicol Pharmacol. 1997 Feb;25(1):26-42. Review.PMID: 9056499 [PubMed - indexed for MEDLINE]Related articles

Trichloroethylene and cancer: epidemiologic evidence

Scott CS, Cogliano VJ.

Environ Health Perspect. 2000 May;108 Suppl 2:159-60.PMID: 10807549 [PubMed - as supplied by publisher]Related articles

Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly.

Evans MV, Chiu WA, Okino MS, Caldwell JC.

Toxicol Appl Pharmacol. 2009 May 1;236(3):329-40. Epub 2009 Feb 26.PMID: 19249323 [PubMed - indexed for MEDLINE]Related articles

A unified approach to risk assessment for cancer and noncancer endpoints based on benchmark doses and uncertainty/safety factors.

Gaylor DW, Kodell RL, Chen JJ, Krewski D.

Regul Toxicol Pharmacol. 1999 Apr;29(2 Pt 1):151-7.PMID: 10341145 [PubMed - indexed for MEDLINE]Related articles

Reassessing benzene risks using internal doses and Monte-Carlo uncertainty analysis.

Cox LA Jr.

Environ Health Perspect. 1996 Dec;104 Suppl 6:1413-29.PMID: 9118928 [PubMed - indexed for MEDLINE]Related articlesFree article

Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane.

Lu Y, Rieth S, Lohitnavy M, Dennison J, El-Masri H, Barton HA, Bruckner J, Yang RS.

Regul Toxicol Pharmacol. 2008 Mar;50(2):249-60. Epub 2007 Dec 14.PMID: 18226845 [PubMed - indexed for MEDLINE]Related articles

Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations.

Sweeney LM, Tyler TR, Kirman CR, Corley RA, Reitz RH, Paustenbach DJ, Holson JF, Whorton MD, Thompson KM, Gargas ML.

Toxicol Sci. 2001 Jul;62(1):124-39.PMID: 11399800 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of mechanistic information in risk assessment for toxic chemicals.

Becking GC.

Toxicol Lett. 1995 May;77(1-3):15-24. Review.PMID: 7618129 [PubMed - indexed for MEDLINE]Related articles

Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: an example with acrylic acid.

Andersen M, Sarangapani R, Gentry R, Clewell H, Covington T, Frederick CB.

Toxicol Sci. 2000 Oct;57(2):312-25.PMID: 11006361 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans.

Allen BC, Fisher JW.

Risk Anal. 1993 Feb;13(1):71-86.PMID: 8451462 [PubMed - indexed for MEDLINE]Related articles