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Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario.

Boyes WK, Bushnell PJ, Crofton KM, Evans M, Simmons JE.

Environ Health Perspect. 2000 May;108 Suppl 2:317-22. Review.PMID: 10807561 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual function.

Boyes WK, Bercegeay M, Ali JS, Krantz T, McGee J, Evans M, Raymer JH, Bushnell PJ, Simmons JE.

Toxicol Sci. 2003 Nov;76(1):121-30. Epub 2003 Aug 12.PMID: 12915717 [PubMed - indexed for MEDLINE]Related articlesFree article

Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats.

Bushnell PJ.

Fundam Appl Toxicol. 1997 Mar;36(1):30-8.PMID: 9073464 [PubMed - indexed for MEDLINE]Related articles

Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model.

Boyes WK, Evans MV, Eklund C, Janssen P, Simmons JE.

Risk Anal. 2005 Jun;25(3):677-86.PMID: 16022699 [PubMed - indexed for MEDLINE]Related articles

A physiologically based pharmacokinetic model for trichloroethylene in the male long-evans rat.

Simmons JE, Boyes WK, Bushnell PJ, Raymer JH, Limsakun T, McDonald A, Sey YM, Evans MV.

Toxicol Sci. 2002 Sep;69(1):3-15.PMID: 12215655 [PubMed - indexed for MEDLINE]Related articlesFree article

Momentary brain concentration of trichloroethylene predicts the effects on rat visual function.

Boyes WK, Bercegeay M, Krantz T, Evans M, Benignus V, Simmons JE.

Toxicol Sci. 2005 Sep;87(1):187-96. Epub 2005 Jun 23.PMID: 15976185 [PubMed - indexed for MEDLINE]Related articlesFree article

The ototoxicity of trichloroethylene: extrapolation and relevance of high-concentration, short-duration animal exposure data.

Crofton KM, Zhao X.

Fundam Appl Toxicol. 1997 Jul;38(1):101-6.PMID: 9268609 [PubMed - indexed for MEDLINE]Related articles

Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. II. 1,1,1-Trichloroethane and trichloroethylene.

Laparé S, Tardif R, Brodeur J.

Int Arch Occup Environ Health. 1995;67(6):375-94.PMID: 8567088 [PubMed - indexed for MEDLINE]Related articles

Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose.

Simmons JE, Evans MV, Boyes WK.

J Toxicol Environ Health A. 2005 Jun 11-25;68(11-12):927-50.PMID: 16020185 [PubMed - indexed for MEDLINE]Related articles

Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats.

Dallas CE, Gallo JM, Ramanathan R, Muralidhara S, Bruckner JV.

Toxicol Appl Pharmacol. 1991 Sep 1;110(2):303-14.PMID: 1891776 [PubMed - indexed for MEDLINE]Related articles

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

Fisher JW, Whittaker TA, Taylor DH, Clewell HJ 3rd, Andersen ME.

Toxicol Appl Pharmacol. 1989 Jul;99(3):395-414.PMID: 2749729 [PubMed - indexed for MEDLINE]Related articles

Development of a screening approach to interpret human biomonitoring data on volatile organic compounds: reverse dosimetry on biomonitoring data for trichloroethylene.

Liao KH, Tan YM, Clewell HJ 3rd.

Risk Anal. 2007 Oct;27(5):1223-36.PMID: 18076492 [PubMed - indexed for MEDLINE]Related articles

Acute effects of trichloroethylene on blood concentrations and performance decrements in rats and their relevance to humans.

Kishi R, Harabuchi I, Ikeda T, Katakura Y, Miyake H.

Br J Ind Med. 1993 May;50(5):470-80.PMID: 8507600 [PubMed - indexed for MEDLINE]Related articlesFree article

Behavioral components of tolerance to repeated inhalation of trichloroethylene (TCE) in rats.

Bushnell PJ, Oshiro WM.

Neurotoxicol Teratol. 2000 Mar-Apr;22(2):221-9.PMID: 10758351 [PubMed - indexed for MEDLINE]Related articles

Tissue dosimetry expansion and cross-validation of rat and mouse physiologically based pharmacokinetic models for trichloroethylene.

Keys DA, Bruckner JV, Muralidhara S, Fisher JW.

Toxicol Sci. 2003 Nov;76(1):35-50. Epub 2003 Aug 12.PMID: 12915716 [PubMed - indexed for MEDLINE]Related articlesFree article

Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint.

Miller FJ, Schlosser PM, Janszen DB.

Toxicology. 2000 Aug 14;149(1):21-34. Review.PMID: 10963858 [PubMed - indexed for MEDLINE]Related articles

Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.

Dobrev ID, Andersen ME, Yang RS.

Arch Toxicol. 2001 May;75(3):134-44.PMID: 11409535 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans.

Allen BC, Fisher JW.

Risk Anal. 1993 Feb;13(1):71-86.PMID: 8451462 [PubMed - indexed for MEDLINE]Related articles

Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes.

Haddad S, Tardif GC, Tardif R.

J Toxicol Environ Health A. 2006 Dec;69(23):2095-136.PMID: 17060096 [PubMed - indexed for MEDLINE]Related articles

In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane.

Dobrev ID, Andersen ME, Yang RS.

Environ Health Perspect. 2002 Oct;110(10):1031-9.PMID: 12361929 [PubMed - indexed for MEDLINE]Related articlesFree article