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Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites.

Fisher JW.

Environ Health Perspect. 2000 May;108 Suppl 2:265-73. Review.PMID: 10807557 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly.

Evans MV, Chiu WA, Okino MS, Caldwell JC.

Toxicol Appl Pharmacol. 2009 May 1;236(3):329-40. Epub 2009 Feb 26.PMID: 19249323 [PubMed - indexed for MEDLINE]Related articles

A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice.

Abbas R, Fisher JW.

Toxicol Appl Pharmacol. 1997 Nov;147(1):15-30.PMID: 9356303 [PubMed - indexed for MEDLINE]Related articles

Issues in the pharmacokinetics of trichloroethylene and its metabolites.

Chiu WA, Okino MS, Lipscomb JC, Evans MV.

Environ Health Perspect. 2006 Sep;114(9):1450-6. Review.PMID: 16966104 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

Fisher JW, Whittaker TA, Taylor DH, Clewell HJ 3rd, Andersen ME.

Toxicol Appl Pharmacol. 1989 Jul;99(3):395-414.PMID: 2749729 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans.

Allen BC, Fisher JW.

Risk Anal. 1993 Feb;13(1):71-86.PMID: 8451462 [PubMed - indexed for MEDLINE]Related articles

A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.

Fisher JW, Mahle D, Abbas R.

Toxicol Appl Pharmacol. 1998 Oct;152(2):339-59.PMID: 9853003 [PubMed - indexed for MEDLINE]Related articles

Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.

Greenberg MS, Burton GA, Fisher JW.

Toxicol Appl Pharmacol. 1999 Feb 1;154(3):264-78.PMID: 9931286 [PubMed - indexed for MEDLINE]Related articles

Metabolism of trichloroethylene.

Lash LH, Fisher JW, Lipscomb JC, Parker JC.

Environ Health Perspect. 2000 May;108 Suppl 2:177-200. Review.PMID: 10807551 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

Fisher JW, Whittaker TA, Taylor DH, Clewell HJ 3rd, Andersen ME.

Toxicol Appl Pharmacol. 1990 Mar 1;102(3):497-513.PMID: 2315918 [PubMed - indexed for MEDLINE]Related articles

Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse.

Fisher JW, Gargas ML, Allen BC, Andersen ME.

Toxicol Appl Pharmacol. 1991 Jun 15;109(2):183-95.PMID: 2068722 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Kim S, Kim D, Pollack GM, Collins LB, Rusyn I.

Toxicol Appl Pharmacol. 2009 Jul 1;238(1):90-9. Epub 2009 May 3.PMID: 19409406 [PubMed - indexed for MEDLINE]Related articles

Tissue dosimetry expansion and cross-validation of rat and mouse physiologically based pharmacokinetic models for trichloroethylene.

Keys DA, Bruckner JV, Muralidhara S, Fisher JW.

Toxicol Sci. 2003 Nov;76(1):35-50. Epub 2003 Aug 12.PMID: 12915716 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

Clewell HJ 3rd, Gentry PR, Covington TR, Gearhart JM.

Environ Health Perspect. 2000 May;108 Suppl 2:283-305. Review.PMID: 10807559 [PubMed - indexed for MEDLINE]Related articlesFree article

A trichloroethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling.

Cronin WJ 4th, Oswald EJ, Shelley ML, Fisher JW, Flemming CD.

Risk Anal. 1995 Oct;15(5):555-65.PMID: 7501875 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics for regulatory risk analysis: the case of trichloroethylene.

Bogen KT.

Regul Toxicol Pharmacol. 1988 Dec;8(4):447-66.PMID: 3222486 [PubMed - indexed for MEDLINE]Related articles

Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

Hack CE, Chiu WA, Jay Zhao Q, Clewell HJ.

Regul Toxicol Pharmacol. 2006 Oct;46(1):63-83. Epub 2006 Aug 4.PMID: 16889879 [PubMed - indexed for MEDLINE]Related articles

Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic recirculation of major metabolites.

Stenner RD, Merdink JL, Fisher JW, Bull RJ.

Risk Anal. 1998 Jun;18(3):261-9.PMID: 9664722 [PubMed - indexed for MEDLINE]Related articles

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.

Clewell HJ, Andersen ME.

Crit Rev Toxicol. 2004 Sep-Oct;34(5):385-445. Review.PMID: 15560567 [PubMed - indexed for MEDLINE]Related articles

The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans.

Lipscomb JC, Teuschler LK, Swartout J, Popken D, Cox T, Kedderis GL.

Risk Anal. 2003 Dec;23(6):1221-38.PMID: 14641897 [PubMed - indexed for MEDLINE]Related articles