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Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.

Bull RJ.

Environ Health Perspect. 2000 May;108 Suppl 2:241-59. Review.PMID: 10807555 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.

Corton JC.

Crit Rev Toxicol. 2008;38(10):857-75. Review.PMID: 18821149 [PubMed - indexed for MEDLINE]Related articles

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

Bull RJ, Orner GA, Cheng RS, Stillwell L, Stauber AJ, Sasser LB, Lingohr MK, Thrall BD.

Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65.PMID: 12127263 [PubMed - indexed for MEDLINE]Related articles

Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate.

Larson JL, Bull RJ.

Toxicol Appl Pharmacol. 1992 Aug;115(2):278-85.PMID: 1641861 [PubMed - indexed for MEDLINE]Related articles

Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.

Laughter AR, Dunn CS, Swanson CL, Howroyd P, Cattley RC, Corton JC.

Toxicology. 2004 Oct 15;203(1-3):83-98.PMID: 15363585 [PubMed - indexed for MEDLINE]Related articles

Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.

Bull RJ, Sasser LB, Lei XC.

Toxicology. 2004 Jul 1;199(2-3):169-83.PMID: 15147791 [PubMed - indexed for MEDLINE]Related articles

Biologically based dose-response model for liver tumors induced by trichloroethylene.

Chen CW.

Environ Health Perspect. 2000 May;108 Suppl 2:335-42.PMID: 10807563 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.

Walgren JE, Kurtz DT, McMillan JM.

Cell Biol Toxicol. 2000;16(4):257-73.PMID: 11101007 [PubMed - indexed for MEDLINE]Related articles

The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene.

Bull RJ, Templin M, Larson JL, Stevens DK.

Toxicol Lett. 1993 May;68(1-2):203-11.PMID: 8516764 [PubMed - indexed for MEDLINE]Related articles

Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.

Moore MM, Harrington-Brock K.

Environ Health Perspect. 2000 May;108 Suppl 2:215-23. Review.PMID: 10807553 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice.

Templin MV, Parker JC, Bull RJ.

Toxicol Appl Pharmacol. 1993 Nov;123(1):1-8. Erratum in: Toxicol Appl Pharmacol 1995 Jul;133(1):177. PMID: 8236248 [PubMed - indexed for MEDLINE]Related articles

Dissimilar characteristics of N-methyl-N-nitrosourea-initiated foci and tumors promoted by dichloroacetic acid or trichloroacetic acid in the liver of female B6C3F1 mice.

Latendresse JR, Pereira MA.

Toxicol Pathol. 1997 Sep-Oct;25(5):433-40.PMID: 9323830 [PubMed - indexed for MEDLINE]Related articles

Kinetics of chloral hydrate and its metabolites in male human volunteers.

Merdink JL, Robison LM, Stevens DK, Hu M, Parker JC, Bull RJ.

Toxicology. 2008 Mar 12;245(1-2):130-40. Epub 2007 Dec 28.PMID: 18243465 [PubMed - indexed for MEDLINE]Related articles

Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA).

Stauber AJ, Bull RJ.

Toxicol Appl Pharmacol. 1997 Jun;144(2):235-46.PMID: 9194407 [PubMed - indexed for MEDLINE]Related articles

Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.

Walgren JL, Kurtz DT, McMillan JM.

Toxicology. 2005 Aug 1;211(3):220-30. Epub 2005 Apr 21.PMID: 15925025 [PubMed - indexed for MEDLINE]Related articles

Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate.

Bull RJ, Sanchez IM, Nelson MA, Larson JL, Lansing AJ.

Toxicology. 1990 Sep;63(3):341-59.PMID: 2219130 [PubMed - indexed for MEDLINE]Related articles

The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice.

Merdink JL, Gonzalez-Leon A, Bull RJ, Schultz IR.

Toxicol Sci. 1998 Sep;45(1):33-41.PMID: 9848108 [PubMed - indexed for MEDLINE]Related articles

Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

Caldwell JC, Keshava N.

Environ Health Perspect. 2006 Sep;114(9):1457-63. Review.PMID: 16966105 [PubMed - indexed for MEDLINE]Related articlesFree article

The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.

Herren-Freund SL, Pereira MA, Khoury MD, Olson G.

Toxicol Appl Pharmacol. 1987 Sep 15;90(2):183-9.PMID: 3629594 [PubMed - indexed for MEDLINE]Related articles

Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer.

Barton HA, Bull R, Schultz I, Andersen ME.

Toxicol Lett. 1999 May 20;106(1):9-21.PMID: 10378446 [PubMed - indexed for MEDLINE]Related articles