Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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SMS, Homo sapiens
spermine synthase |
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NP_004586.2
366 aa |
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SMS, Pan troglodytes
spermine synthase |
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XP_001142843.1
367 aa |
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SMS, Canis lupus familiaris
spermine synthase |
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XP_849539.1
313 aa |
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SMS, Bos taurus
spermine synthase |
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NP_001030548.1
365 aa |
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Sms, Mus musculus
spermine synthase |
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NP_033240.3
366 aa |
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Gm14680, Mus musculus
predicted gene 14680 |
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XP_001473484.1
366 aa |
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Sms, Rattus norvegicus
spermine synthase |
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NP_001029071.1
366 aa |
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LOC690027, Rattus norvegicus
similar to spermine synthase |
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XP_001073039.1
366 aa |
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SMS, Gallus gallus
spermine synthase |
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NP_001025974.1
367 aa |
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sms, Danio rerio
spermine synthase |
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NP_571831.1
360 aa |
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CG4300, Drosophila melanogaster
CG4300, isoform B |
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NP_729798.1
367 aa |
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AgaP_AGAP005325, Anopheles gambiae
AGAP005325-PA |
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XP_315341.4
374 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Mental retardation, X-linked, Snyder-Robinson type. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Becerra-Solano LE, et al.A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome. Am J Med Genet A 149A, 328-35(2009). |
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Wang X, et al.Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. J Biol Chem 284, 930-7(2009). |
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de Alencastro G, et al.New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome. J Med Genet 45, 539-43(2008). |
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Cason AL, et al.X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet 11, 937-44(2003). |
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Korhonen VP, et al.Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol 59, 231-8(2001). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Sms includes H.sapiens SMS and R.norvegicus Sms. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Strain Liverpool |
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Transcribed locus, strongly similar to XP_315341.4 AGAP005325-PA [Anopheles ... |
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Similar to CG4300-PA, isoform A |
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Spermine synthase |
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Hypothetical LOC534520 |
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Spermine synthase |
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Spermine synthase |
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Similar to spermine synthase |
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CG4300 |
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Similar to Spermine synthase |
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Spermine synthase |
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Clone CNB221-B06 mRNA sequence |
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Spermine synthase |
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Similar to spermine synthase |
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Transcribed locus, strongly similar to NP_001025974.1 spermine synthase [Gal... |
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Similar to spermine synthase |
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Similar to spermine synthase |
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Similar to spermine synthase |
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Spermine synthase |
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Transcribed locus, strongly similar to NP_004586.2 spermine synthase [Homo s... |
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Transcribed locus, moderately similar to NP_571831.1 hypothetical protein LO... |
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Transcribed locus, moderately similar to NP_571831.1 spermine synthase [Dani... |
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Transcribed locus, strongly similar to NP_004586.2 spermine synthase [Homo s... |
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Transcribed locus, strongly similar to NP_004586.2 spermine synthase [Homo s... |
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Transcribed locus, strongly similar to NP_571831.1 spermine synthase [Danio ... |
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Spermine synthase |
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Similar to spermine synthase |
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Transcribed locus, strongly similar to NP_004586.2 spermine synthase [Homo s... |
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Transcribed locus, moderately similar to NP_571831.1 spermine synthase [Dani... |
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Similar to spermine synthase |
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Transcribed locus, strongly similar to NP_004586.2 spermine synthase [Homo s... |
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Transcribed locus, strongly similar to NP_001025974.1 spermine synthase [Gal... |
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Similar to CG4300-PB, isoform B |
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Transcribed locus, strongly similar to XP_001367125.1 PREDICTED: hypothetica... |
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CDNA clone IMAGE:7648282 |
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