Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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MLH1, Homo sapiens
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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NP_000240.1
756 aa |
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MLH1, Pan troglodytes
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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XP_001170433.1
756 aa |
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MLH1, Canis lupus familiaris
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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XP_534219.2
757 aa |
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MLH1, Bos taurus
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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XP_001790604.1
758 aa |
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Mlh1, Mus musculus
mutL homolog 1 (E. coli) |
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NP_081086.1
760 aa |
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Mlh1, Rattus norvegicus
mutL homolog 1 (E. coli) |
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NP_112315.1
757 aa |
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MLH1, Gallus gallus
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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XP_418828.1
757 aa |
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mlh1, Danio rerio
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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NP_956953.1
724 aa |
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Mlh1, Drosophila melanogaster
Mlh1 |
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NP_477022.1
664 aa |
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AgaP_AGAP012192, Anopheles gambiae
AGAP012192-PA |
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XP_320342.4
674 aa |
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mlh1, Schizosaccharomyces pombe
MutL family protein Mlh1 (predicted) |
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NP_596199.1
684 aa |
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MLH1, Saccharomyces cerevisiae
Mlh1p |
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NP_013890.1
769 aa |
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KLLA0D09955g, Kluyveromyces lactis
hypothetical protein |
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XP_453504.1
724 aa |
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AGOS_AFL199C, Eremothecium gossypii
AFL199Cp |
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NP_985351.1
771 aa |
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MGG_07121, Magnaporthe grisea
hypothetical protein |
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XP_367196.2
690 aa |
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NCU08309.1, Neurospora crassa
hypothetical protein |
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XP_329015.1
751 aa |
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PF11_0184, Plasmodium falciparum
DNA mismatch repair protein MLH1 |
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XP_001347855.1
1016 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Cafe-au-lait spots with glioma or leukemia. |
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Muir-Torre syndrome. |
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Turcot syndrome with glioblastoma. |
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Colorectal cancer, hereditary nonpolyposis, type 2. |
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Mus musculus |
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Tumorigenesis. Induction of new growth. |
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Life span-post-weaning/aging. |
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Homeostasis/metabolism phenotype. |
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Endocrine/exocrine gland phenotype. |
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Cellular phenotype. |
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Reproductive system phenotype. |
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Skin/coat/nails phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Stupart DA, et al.Cancer risk in a cohort of subjects carrying a single mismatch repair gene mutation. Fam Cancer 8, 519-23(2009). |
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Nejda N, et al.A MLH1 polymorphism that increases cancer risk is associated with better outcome in sporadic colorectal cancer. Cancer Genet Cytogenet 193, 71-7(2009). |
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Imesch P, et al.MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. Int J Oncol 35, 631-40(2009). |
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Takahashi R & Nagai K.Differences in expression between transcripts using alternative promoters of hMLH1 gene and their correlation with microsatellite instability. Oncol Rep 22, 265-71(2009). |
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Mei M, et al.Clinical implications of microsatellite instability and MLH1 gene inactivation in sporadic insulinomas. J Clin Endocrinol Metab 94, 3448-57(2009). |
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Mlh1 includes H.sapiens MLH1 and R.norvegicus Mlh1. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Strain Liverpool |
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Similar to MutL protein homolog 1 |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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Mlh1 |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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DNA binding protein, putative |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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Transcribed locus, moderately similar to XP_707000.1 PREDICTED: similar to M... |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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Transcribed locus, weakly similar to XP_001690102.1 mismatch repair protein ... |
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MutL homolog 1 (E. coli) |
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Transcribed locus, moderately similar to NP_956953.1 mutL homolog 1, colon c... |
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Transcribed locus, strongly similar to NP_000240.1 MutL protein homolog 1 [H... |
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Transcribed locus, strongly similar to NP_000240.1 MutL protein homolog 1 [H... |
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Transcribed locus, strongly similar to NP_000240.1 MutL protein homolog 1 [H... |
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Transcribed locus, strongly similar to XP_793318.2 PREDICTED: similar to DNA... |
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Transcribed locus, strongly similar to NP_956953.1 mutL homolog 1, colon can... |
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MutL homolog 1 (E. coli) |
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Similar to DNA mismatch repair protein homolog |
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Transcribed locus, strongly similar to NP_000240.1 MutL protein homolog 1 [H... |
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Transcribed locus, moderately similar to XP_418828.1 PREDICTED: similar to D... |
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Transcribed locus, strongly similar to XP_001102056.1 PREDICTED: similar to ... |
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MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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Transcribed locus, strongly similar to NP_001090545.1 MutL protein homolog 1... |
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MutL protein homolog 1 |
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