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1: HomoloGene:20545. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

 Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
   MMP3,  Homo sapiens
matrix metallopeptidase 3 (stromelysin 1, progelatinase)		     NP_002413.1
477 aa		 Domain ImageDomain ImageDomain Image
   MMP3,  Pan troglodytes
matrix metallopeptidase 3 (stromelysin 1, progelatinase)		     XP_508723.2
477 aa		 Domain ImageDomain ImageDomain Image
   MMP3,  Canis lupus familiaris
matrix metallopeptidase 3 (stromelysin 1, progelatinase)		     NP_001002967.1
478 aa		 Domain ImageDomain ImageDomain Image
   MMP3,  Bos taurus
matrix metallopeptidase 3 (stromelysin 1, progelatinase)		     XP_586521.2
477 aa		 Domain ImageDomain ImageDomain Image
   Mmp3,  Mus musculus
matrix metallopeptidase 3		     NP_034939.1
479 aa		 Domain ImageDomain ImageDomain Image
   Mmp3,  Rattus norvegicus
matrix metallopeptidase 3		     NP_598207.1
475 aa		 Domain ImageDomain ImageDomain Image
   MMP3,  Gallus gallus
matrix metallopeptidase 3 (stromelysin 1, progelatinase)		     XP_417175.1
496 aa		 Domain ImageDomain ImageDomain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Homo sapiens
 
Coronary heart disease, susceptibility to.
 
Mus musculus
 
Nervous system phenotype.
 
Homeostasis/metabolism phenotype.
 
Immune system phenotype.
 
Skeleton phenotype.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Santus P, et al.
Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease. Monaldi Arch Chest Dis 71, 15-20(2009).
 
Wright JW, et al.
Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3. Behav Brain Res 203, 27-34(2009).
 
Barutcu I, et al.
Circulating stromelysin concentration is elevated in hypertensive aortic root dilatation. Heart Vessels 24, 138-41(2009).
 
Kallenbach K, et al.
Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3. J Vasc Surg 49, 750-8(2009).
 
Kucukali CI, et al.
Do schizophrenia and bipolar disorders share a common disease susceptibility variant at the MMP3 gene? Prog Neuropsychopharmacol Biol Psychiatry 33, 557-61(2009).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
 
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...
 
HX (cl02471)
  Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Mmp3 includes H.sapiens MMP3 and R.norvegicus Mmp3.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 
Matrix metalloproteinase 3
 
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 
Matrix metallopeptidase 3
 
Similar to matrix metalloproteinase-3
 
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 
Matrix metalloproteinase 10
 
Matrix metallopeptidase 3
 
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 
Transcribed locus, strongly similar to NP_002413.1 matrix metalloproteinase ...
 
Transcribed locus, strongly similar to NP_002413.1 matrix metalloproteinase ...
 
Mmp10 protein
 
Matrix metalloproteinase 13 (collagenase 3)
 
Hypothetical protein MGC69070
 
Hypothetical LOC495372