SMAD3 SMAD family member 3 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: SMAD3provided by CGNC
Official Full Name: SMAD family member 3provided by CGNC
Primary source: CGNC:5954
See related: Ensembl:ENSGALG00010018099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MADH3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (18814590..18878841)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (18679407..18743653)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell intercalation driven by SMAD3 underlies secondary neural tube formation.
Title: Cell intercalation driven by SMAD3 underlies secondary neural tube formation.
Results show that smad3 is phosphorylated after knocking-down CSRP3 suppressing chicken satellite cell differentiation.
Title: Knockdown of CSRP3 inhibits differentiation of chicken satellite cells by promoting TGF-β/Smad3 signaling.
IMF deposition in skeletal muscle of SLD chicken is regulated partially by pathways of adipocytokine and insulin and other downstream signaling pathways (TGF- beta /SMAD3 and Wnt/catenin- beta pathway).
Title: Analysis of differentially expressed genes and signaling pathways related to intramuscular fat deposition in skeletal muscle of sex-linked dwarf chickens.
Smad2 target proteins are activated solely by the Smad2-Smad2-Smad4 complex, whereas Smad3 targets are activated both by Smad2-Smad3-Smad4 and Smad3-Smad3-Smad4 trimers.
Title: Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis.
In conclusion, these studies suggested the decorin-mediated myostatin/Smad signaling pathway might be involved in the regulation of avian myoblast proliferation.
Title: Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway.
In chickens with reduced muscling, satellite cells are more responsive to a Smad3-dependent TGF-beta1 signaling pathway than normal satellite cells, and a Smad3-independent pathway is also likely involved in the regulation of satellite cells.
Title: Effect of Smad3-mediated transforming growth factor-beta1 signaling on satellite cell proliferation and differentiation in chickens.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of heteromeric SMAD protein complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mothers against decapentaplegic homolog 3

Names: MAD homolog 3; SMAD 3; SMAD, mothers against DPP homolog 3; TGF-beta response effector Smad3; mad3; mothers against DPP homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204475.2 → NP_989806.1 mothers against decapentaplegic homolog 3

See identical proteins and their annotated locations for NP_989806.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000246

UniProtKB/Swiss-Prot

P84023

UniProtKB/TrEMBL

A0A8V0YYB0

Related

ENSGALP00010026038.1, ENSGALT00010043781.1

Conserved Domains (2) summary

cd10491
Location:8 → 132

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:225 → 415

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

18814590..18878841

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046898882.1 → XP_046754838.1 mothers against decapentaplegic homolog 3 isoform X1
XM_015292068.4 → XP_015147554.1 mothers against decapentaplegic homolog 3 isoform X1

UniProtKB/TrEMBL

Q9I9P1

Conserved Domains (2) summary

cd10985
Location:120 → 310

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

cl00055
Location:1 → 27

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_025153794.3 → XP_025009562.1 mothers against decapentaplegic homolog 3 isoform X1

UniProtKB/TrEMBL

Q9I9P1

Conserved Domains (2) summary

cd10985
Location:120 → 310

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

cl00055
Location:1 → 27

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_046898883.1 → XP_046754839.1 mothers against decapentaplegic homolog 3 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

18679407..18743653

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046924469.1 → XP_046780425.1 mothers against decapentaplegic homolog 3 isoform X1
XM_046924468.1 → XP_046780424.1 mothers against decapentaplegic homolog 3 isoform X1
XM_046924467.1 → XP_046780423.1 mothers against decapentaplegic homolog 3 isoform X1
XM_046924470.1 → XP_046780426.1 mothers against decapentaplegic homolog 3 isoform X1