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3-Oxoacyl-(Acyl-Carrier-Protein) Synthase
An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41.
Year introduced: 1998(1975)
alpha-helical corticotropin releasing hormone (3-41), Tyr(3), Pro(4), Nle(18,21)- [Supplementary Concept]
Date introduced: November 18, 1986
4-Nitrophenylphosphatase
An enzyme that catalyzes the hydrolysis of nitrophenyl phosphates to nitrophenols. At acid pH it is probably ACID PHOSPHATASE (EC 3.1.3.2); at alkaline pH it is probably ALKALINE PHOSPHATASE (EC 3.1.3.1). EC 3.1.3.41.
Year introduced: 1994
endothelin-3 (1-41)amide [Supplementary Concept]
an endothelin precursor
Date introduced: November 20, 1995
midostaurin [Supplementary Concept]
Date introduced: August 7, 2014
(2-cyano-3-(methylamino)phenyl)oxoacetic acid [Supplementary Concept]
orally active antiallergy agent; RN given is for Na salt
Date introduced: August 25, 1981
Isoamylase
An enzyme that hydrolyzes 1,6-alpha-glucosidic branch linkages in glycogen, amylopectin, and their beta-limit dextrins. It is distinguished from pullulanase (EC 3.2.1.41) by its inability to attack pullulan and by the feeble action of alpha-limit dextrins. It is distinguished from amylopectin 6-glucanohydrolase (EC 3.2.1.69) by its action on glycogen. With EC 3.2.1.69, it produces the activity called "debranching enzyme". EC 3.2.1.68.
Year introduced: 1991(1975)
10-(benzoyloxymethyl)-9-(3-chloro-4-(tri-n-butylstannyl)benzylidene)-7-azatricyclo(4.3.1.0)-decane [Supplementary Concept]
J Med Chem 2002 Apr 25;45(9):1930-41
Date introduced: May 9, 2002
3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione [Supplementary Concept]
a glycogen synthase kinase-3 inhibitor with antineoplastic activity; structure in first source
Date introduced: February 10, 2015
Ro 41-3696 [Supplementary Concept]
a partial benzodiazepine receptor agonist
Date introduced: March 17, 1995
tromantadine [Supplementary Concept]
Date introduced: January 1, 1973
Ketanserin
A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
Year introduced: 1987
4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester [Supplementary Concept]
structure in first source
Date introduced: October 30, 2007
5,11,17,23,29,35-hexakis(1,1,3,3-tetramethylbutyl)-37,38,39,40,41,42-hexakis(carboxy methoxy)calix(6)arene [Supplementary Concept]
Date introduced: May 24, 2006
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine [Supplementary Concept]
Date introduced: April 13, 2001
C3-cleaving proteinase, 39 kDa [Supplementary Concept]
cleaves C3, the third compnent of complement; shows amino acid sequence identities with 4 regions of procathepsin L; expressed on surface of melanoma cells; amino acid sequence given in first source; 39 kDa from murine melanoma cell line, 41 kDa from human melanoma cell line shares antigenic determinants with 39 kDa proteinase and cathepsin L
Date introduced: February 9, 1996
Ro 41-5253 [Supplementary Concept]
a synthetic retinoid with antiviral activity; a selective RAR alpha antagonist; structure given in first source
Date introduced: January 19, 1994
amylopullulanase [Supplementary Concept]
has both pullulanase (EC 3.2.1.41) and alpha-amylase (EC 3.2.1.1) activities; apuA encodes alkaline amylopullulanase from Bacillus; amino acid sequence in first source; GenBank M97665
Date introduced: September 3, 1993
Ro 41-9067 [Supplementary Concept]
structure given in first source
Date introduced: August 16, 1993
proendothelin 3 [Supplementary Concept]
contains 41 amino acids in humans
Date introduced: December 17, 1992