Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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NR1H4, Homo sapiens
nuclear receptor subfamily 1, group H, member 4 |
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NP_005114.1
472 aa |
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NR1H4, Pan troglodytes
nuclear receptor subfamily 1, group H, member 4 |
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XP_001153645.1
476 aa |
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NR1H4, Canis lupus familiaris
nuclear receptor subfamily 1, group H, member 4 |
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XP_852959.1
472 aa |
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NR1H4, Bos taurus
nuclear receptor subfamily 1, group H, member 4 |
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NP_001029880.1
482 aa |
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Nr1h4, Mus musculus
nuclear receptor subfamily 1, group H, member 4 |
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NP_033134.1
484 aa |
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Nr1h4, Rattus norvegicus
nuclear receptor subfamily 1, group H, member 4 |
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NP_068513.1
469 aa |
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NR1H4, Gallus gallus
nuclear receptor subfamily 1, group H, member 4 |
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NP_989444.1
473 aa |
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nr1h4, Danio rerio
nuclear receptor subfamily 1, group H, member 4 |
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NP_001002574.1
483 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Mus musculus |
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Liver/biliary system phenotype. |
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Life span-post-weaning/aging. |
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Homeostasis/metabolism phenotype. |
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Growth/size phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Lukovac S, et al.Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice. Am J Physiol Gastrointest Liver Physiol 297, G520-31(2009). |
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Li J, et al.Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. J Pharmacol Exp Ther 331, 234-43(2009). |
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van Dijk TH, et al.An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice. J Biol Chem 284, 10315-23(2009). |
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Cariou B.The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis. Diabetes Metab 34, 685-91(2008). |
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Nomoto M, et al.Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. Biol Pharm Bull 32, 172-8(2009). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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NR_LBD (cl11397) The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators. |
Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Nr1h4 includes H.sapiens NR1H4 and R.norvegicus Nr1h4. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Nuclear receptor subfamily 1, group H, member 4 |
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Nuclear receptor subfamily 1, group H, member 4 |
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Nuclear receptor, complete cds, clone: cidg803k09 |
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Nuclear receptor subfamily 1, group H, member 4 |
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Expressed sequence DQ017614 |
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Nuclear receptor subfamily 1, group H, member 4 |
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Nuclear receptor subfamily 1, group H, member 4 |
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Transcribed locus, strongly similar to NP_033134.1 nuclear receptor subfamil... |
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Nuclear receptor subfamily 1, group H, member 4 |
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Nuclear receptor subfamily 1, group H, member 4 |
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Nuclear receptor subfamily 1, group H, member 4 |
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Farnesoid X activated receptor |
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Transcribed locus, strongly similar to NP_001002574.1 nuclear receptor subfa... |
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Nuclear receptor subfamily 1, group H, member 4 |
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Transcribed locus, strongly similar to NP_001029880.1 nuclear receptor subfa... |
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