Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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SGCA, Homo sapiens
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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NP_000014.1
387 aa |
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SGCA, Pan troglodytes
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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XP_523792.2
526 aa |
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SGCA, Canis lupus familiaris
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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XP_851587.1
377 aa |
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SGCA, Bos taurus
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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NP_001013420.1
388 aa |
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Sgca, Mus musculus
sarcoglycan, alpha (dystrophin-associated glycoprotein) |
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NP_033187.1
387 aa |
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Sgca, Rattus norvegicus
sarcoglycan, alpha (dystrophin-associated glycoprotein) |
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XP_220884.4
387 aa |
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sgca, Danio rerio
sarcoglycan, alpha |
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XP_685270.2
377 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Adhalinopathy, primary. |
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Muscular dystrophy, limb-girdle, type 2D. |
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Mus musculus |
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Muscle phenotype. |
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Homeostasis/metabolism phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Kobuke K, et al.A common disease-associated missense mutation in alpha-sarcoglycan fails to cause muscular dystrophy in mice. Hum Mol Genet 17, 1201-13(2008). |
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Bartoli M, et al.Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation. Hum Mol Genet 17, 1214-21(2008). |
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Danieli-Betto D, et al.Deficiency of alpha-sarcoglycan differently affects fast- and slow-twitch skeletal muscles. Am J Physiol Regul Integr Comp Physiol 289, R1328-37(2005). |
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Jakubiec-Puka A, et al.Ultrastructure of diaphragm from dystrophic alpha-sarcoglycan-null mice. Acta Biochim Pol 52, 453-60(2005). |
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Consolino CM, et al.Muscles of mice deficient in alpha-sarcoglycan maintain large masses and near control force values throughout the life span. Physiol Genomics 22, 244-56(2005). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Sgca includes H.sapiens SGCA and R.norvegicus Sgca. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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Sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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Sarcoglycan, alpha |
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Transcribed locus, weakly similar to NP_000014.1 sarcoglycan, alpha (50kDa d... |
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Transcribed locus, weakly similar to XP_685270.2 PREDICTED: hypothetical pro... |
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Sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
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Sarcoglycan, alpha (dystrophin-associated glycoprotein) |
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50-kda dystrophin-associated glycoprotein |
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Transcribed locus, weakly similar to XP_685270.2 PREDICTED: hypothetical pro... |
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Sarcoglycan, alpha (dystrophin-associated glycoprotein) |
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Transcribed locus, moderately similar to NP_033187.1 sarcoglycan, alpha (dys... |
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