Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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MED1, Homo sapiens
mediator complex subunit 1 |
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NP_004765.2
1581 aa |
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MED1, Pan troglodytes
mediator complex subunit 1 |
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XP_001172395.1
1581 aa |
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MED1, Canis lupus familiaris
mediator complex subunit 1 |
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XP_537654.2
1583 aa |
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MED1, Bos taurus
mediator complex subunit 1 |
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XP_598984.2
1575 aa |
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Med1, Mus musculus
mediator complex subunit 1 |
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NP_001073587.1
1575 aa |
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Med1, Rattus norvegicus
mediator complex subunit 1 |
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XP_573188.1
1582 aa |
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MED1, Gallus gallus
mediator complex subunit 1 |
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XP_418125.2
1594 aa |
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LOC571519, Danio rerio
similar to Ppar binding protein |
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XP_700209.3
1707 aa |
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MED1, Drosophila melanogaster
Mediator complex subunit 1 |
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NP_649341.1
1475 aa |
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AgaP_AGAP012219, Anopheles gambiae
AGAP012219-PA |
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XP_320318.4
1753 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Mus musculus |
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Pigmentation phenotype. |
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Nervous system phenotype. |
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Muscle phenotype. |
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Liver/biliary system phenotype. |
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Limbs/digits/tail phenotype. |
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Lethality-prenatal/perinatal. |
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Homeostasis/metabolism phenotype. |
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Growth/size phenotype. |
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Endocrine/exocrine gland phenotype. |
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Embryogenesis phenotype. |
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Craniofacial phenotype. |
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Cellular phenotype. |
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Cardiovascular system phenotype. The observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan. |
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Respiratory system phenotype. |
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Vision/eye phenotype. |
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Hematopoietic system phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Ndong Jde L, et al.Down-regulation of the expression of RB18A/MED1, a cofactor of transcription, triggers strong tumorigenic phenotype of human melanoma cells. Int J Cancer 124, 2597-606(2009). |
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Howard JH, et al.Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer. Cancer Biol Ther 8, 94-100(2009). |
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Belakavadi M, et al.MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling. Mol Cell Biol 28, 3932-42(2008). |
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Matsumoto K, et al.Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. J Biol Chem 282, 17053-60(2007). |
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Li JM, et al.Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy. Biochem Biophys Res Commun 348, 1389-97(2006). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Med1 includes H.sapiens MED1 and R.norvegicus Med1. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Strain Liverpool |
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Similar to Mediator complex subunit 1 CG7162-PA |
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Mediator complex subunit 1 |
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Mediator complex subunit 1 |
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Zgc:111976 |
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Hypothetical LOC571519 |
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Mediator complex subunit 1 |
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Mediator complex subunit 1 |
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Mediator complex subunit 1 |
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Transcribed locus, moderately similar to XP_700209.2 PREDICTED: hypothetical... |
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Mediator complex subunit 1 |
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Testis cDNA, clone: QtsA-15747, similar to human PPAR binding protein (PPARB... |
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Peroxisome proliferator-activated receptor binding protein |
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Mediator complex subunit 1 |
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Transcribed locus, strongly similar to NP_004765.2 mediator complex subunit ... |
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Mediator complex subunit 1 |
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Similar to Peroxisome proliferator-activated receptor-binding protein (PBP) ... |
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Transcribed locus, strongly similar to NP_004765.2 mediator complex subunit ... |
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Transcribed locus, strongly similar to NP_004765.2 mediator complex subunit ... |
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Hypothetical protein LOC100036710 |
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Mediator complex subunit 1 |
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Hypothetical protein LOC443618 |
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Mediator of RNA polymerase II transcription subunit 1 |
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