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1: HomoloGene:7899. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PPARG,  Homo sapiens
peroxisome proliferator-activated receptor gamma
    NP_056953.2
505 aa
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   PPARG,  Pan troglodytes
peroxisome proliferator-activated receptor gamma
    XP_001153669.1
505 aa
Domain ImageDomain Image
   PPARG,  Canis lupus familiaris
peroxisome proliferator-activated receptor gamma
    NP_001019803.1
505 aa
Domain ImageDomain Image
   PPARG,  Bos taurus
peroxisome proliferator-activated receptor gamma
    NP_851367.1
505 aa
Domain ImageDomain Image
   Pparg,  Mus musculus
peroxisome proliferator activated receptor gamma
    NP_035276.1
505 aa
Domain ImageDomain Image
   Pparg,  Rattus norvegicus
peroxisome proliferator-activated receptor gamma
    NP_037256.1
505 aa
Domain ImageDomain Image
   PPARG,  Gallus gallus
peroxisome proliferator-activated receptor gamma
    NP_001001460.1
475 aa
Domain ImageDomain Image
   pparg,  Danio rerio
peroxisome proliferator activated receptor gamma
    XP_001920478.1
369 aa
Domain ImageDomain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Homo sapiens
 
Glioblastoma, susceptibility to.
 
Lipodystrophy, familial partial.
 
Obesity, resistance to.
 
Obesity, severe.
 
Diabetes mellitus, insulin-resistant, with acanthosis nigricans and hypertension.
 
Insulin resistance, severe, digenic.
 
Abdominal body fat distribution, modifier of.
 
Mus musculus
 
Tumorigenesis. Induction of new growth.
 
Normal phenotype.
 
No phenotypic analysis. No description of morphological, physiological or behavioral information presented.
 
Nervous system phenotype.
 
Renal/urinary system phenotype.
 
Muscle phenotype.
 
Liver/biliary system phenotype.
 
Life span-post-weaning/aging.
 
Lethality-postnatal.
 
Lethality-prenatal/perinatal.
 
Adipose tissue phenotype. The observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan.
 
Homeostasis/metabolism phenotype.
 
Hearing/vestibular/ear phenotype.
 
Growth/size phenotype.
 
Endocrine/exocrine gland phenotype.
 
Embryogenesis phenotype.
 
Digestive/alimentary phenotype.
 
Cellular phenotype.
 
Cardiovascular system phenotype. The observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan.
 
Behavior/neurological phenotype. The observable actions or reactions of mammalian organisms that are manifested through development and lifespan.
 
Immune system phenotype.
 
Reproductive system phenotype.
 
Skeleton phenotype.
 
Vision/eye phenotype.
 
Skin/coat/nails phenotype.
 
Hematopoietic system phenotype.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Tsai YS, et al.
Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. Mol Endocrinol 23, 1787-98(2009).
 
Tellechea ML, et al.
Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status. Circ J 73, 2118-24(2009).
 
Klotz L, et al.
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med 206, 2079-89(2009).
 
Ben Ali S, et al.
Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clin Biochem 42, 1642-7(2009).
 
Espadinha C, et al.
Underexpression of PPARgamma is associated with aneuploidy and lower differentiation of thyroid tumours of follicular origin. Oncol Rep 22, 907-13(2009).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
Hormone_recep (cl02604)
  Ligand-binding domain of nuclear hormone receptor.
 
zf-C4 (cl02596)
  Zinc finger, C4 type (two domains).
 
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Pparg includes H.sapiens PPARG and R.norvegicus Pparg.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
TRNA splicing endonuclease 2 homolog (S. cerevisiae)
 
Peroxisome proliferator-activated receptor gamma
 
Peroxisome proliferator activated receptor gamma
 
Peroxisome proliferator-activated receptor gamma
 
Transcribed locus, moderately similar to NP_037273.1 peroxisome proliferator...
 
Peroxisome proliferator-activated receptor gamma
 
Peroxisome proliferator-activated receptor gamma 1 (PPARgamma1)
 
Peroxisome proliferator-activated receptor gamma 1-b
 
Peroxisome proliferator activated receptor gamma
 
PPAR gamma 3
 
Peroxisome proliferator activated receptor gamma 1 protein
 
Transcribed locus, strongly similar to NP_037256.1 peroxisome proliferator a...
 
Peroxisome proliferator activated receptor gamma
 
Peroxisome proliferator activated receptor gamma
 
Peroxisome proliferator-activated receptor gamma
 
Peroxisome proliferators-activated receptor gamma
 
Transcribed locus, strongly similar to NP_001081312.1 peroxisome proliferato...
 
Transcribed locus, moderately similar to NP_001001460.1 peroxisome prolifera...
 
Peroxisome proliferator activated receptor gamma