1: HomoloGene:38166. Gene conserved in Fungi/Metazoa group Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NCOR1,  Homo sapiens
nuclear receptor co-repressor 1
    NP_006302.2
2440 aa
Domain ImageDomain Image
   NCOR1,  Pan troglodytes
nuclear receptor co-repressor 1
    XP_001153894.1
102 aa
   NCOR1,  Canis lupus familiaris
nuclear receptor co-repressor 1
    XP_851485.1
2453 aa
Domain ImageDomain Image
   NCOR1,  Bos taurus
nuclear receptor co-repressor 1
    XP_871804.2
2437 aa
Domain ImageDomain Image
   Ncor1,  Mus musculus
nuclear receptor co-repressor 1
    NP_035438.2
2443 aa
Domain ImageDomain Image
   NCOR1,  Gallus gallus
nuclear receptor co-repressor 1
    XP_415843.2
2442 aa
Domain ImageDomain Image
   ncor1,  Danio rerio
nuclear receptor co-repressor 1
    NP_956570.2
2409 aa
Domain ImageDomain Image
   SPAC22E12.19,  Schizosaccharomyces pombe
histone deacetylase complex subunit (predicted)
    NP_594845.2
661 aa
Domain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Mus musculus
 
No phenotypic analysis. No description of morphological, physiological or behavioral information presented.
 
Nervous system phenotype.
 
Liver/biliary system phenotype.
 
Lethality-prenatal/perinatal.
 
Homeostasis/metabolism phenotype.
 
Growth/size phenotype.
 
Embryogenesis phenotype.
 
Immune system phenotype.
 
Skin/coat/nails phenotype.
 
Hematopoietic system phenotype.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Kashima H, et al.
Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma. Anticancer Res 29, 1023-9(2009).
 
Abedin SA, et al.
Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells. Carcinogenesis 30, 449-56(2009).
 
Zhang D, et al.
A critical role for the co-repressor N-CoR in erythroid differentiation and heme synthesis. Cell Res 17, 804-14(2007).
 
Fernández-Majada V, et al.
Aberrant cytoplasmic localization of N-CoR in colorectal tumors. Cell Cycle 6, 1748-52(2007).
 
Wu Y, et al.
Nuclear compartmentalization of N-CoR and its interactions with steroid receptors. Mol Cell Biol 26, 6633-55(2006).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
SANT (cl00132)
  N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in...



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Ncor1 includes H.sapiens NCOR1 and R.norvegicus Ncor1.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Nuclear receptor co-repressor 1
 
Nuclear receptor co-repressor 1
 
Nuclear receptor co-repressor 1
 
Nuclear receptor co-repressor 1
 
Transcribed locus, weakly similar to XP_690163.1 PREDICTED: similar to KIAA1...
 
Nuclear receptor co-repressor 1
 
Brain cDNA clone: QorA-13189, similar to human nuclear receptor co-repressor...
 
Similar to nuclear receptor co-repressor 1
 
Transcribed locus, weakly similar to NP_956570.2 nuclear receptor co-repress...
 
Nuclear receptor co-repressor 1
 
Predicted gene, EG627299
 
Transcribed locus, strongly similar to NP_006302.2 nuclear receptor co-repre...
 
Transcribed locus, strongly similar to NP_006302.2 nuclear receptor co-repre...
 
Transcribed locus, strongly similar to NP_006302.2 nuclear receptor co-repre...
 
Transcribed locus, strongly similar to NP_956570.2 nuclear receptor co-repre...
 
Nuclear receptor co-repressor 1
 
Transcribed locus, moderately similar to NP_006302.2 nuclear receptor co-rep...
 
Transcribed locus, strongly similar to NP_006302.2 nuclear receptor co-repre...
 
Transcribed locus, moderately similar to NP_035438.2 nuclear receptor co-rep...
 
Nuclear receptor co-repressor 1
 
Transcribed locus, strongly similar to NP_035438.2 nuclear receptor co-repre...
 
Transcribed locus, moderately similar to NP_006302.2 nuclear receptor co-rep...
 
Nuclear receptor co-repressor 1
 
Hypothetical LOC443635
 
Nuclear receptor corepressor
 
Transcribed locus, strongly similar to NP_001082225.1 nuclear receptor corep...