1: HomoloGene:4544. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PPARD,  Homo sapiens
peroxisome proliferator-activated receptor delta
    NP_006229.1
441 aa
Domain ImageDomain Image
   PPARD,  Pan troglodytes
peroxisome proliferator-activated receptor delta
    XP_518905.2
441 aa
Domain ImageDomain Image
   PPARD,  Canis lupus familiaris
peroxisome proliferator-activated receptor delta
    XP_863914.1
441 aa
   PPARD,  Bos taurus
peroxisome proliferator-activated receptor delta
    NP_001077105.1
441 aa
Domain ImageDomain Image
   Ppard,  Mus musculus
peroxisome proliferator activator receptor delta
    NP_035275.1
440 aa
Domain ImageDomain Image
   Ppard,  Rattus norvegicus
peroxisome proliferator-activated receptor delta
    NP_037273.1
440 aa
Domain ImageDomain Image
   PPARD,  Gallus gallus
peroxisome proliferator-activated receptor delta
    NP_990059.1
443 aa
Domain ImageDomain Image
   ppardb,  Danio rerio
peroxisome proliferator-activated receptor delta b
    XP_688284.2
517 aa
Domain ImageDomain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Mus musculus
 
Tumorigenesis. Induction of new growth.
 
Nervous system phenotype.
 
Liver/biliary system phenotype.
 
Lethality-prenatal/perinatal.
 
Adipose tissue phenotype. The observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan.
 
Homeostasis/metabolism phenotype.
 
Growth/size phenotype.
 
Embryogenesis phenotype.
 
Digestive/alimentary phenotype.
 
Behavior/neurological phenotype. The observable actions or reactions of mammalian organisms that are manifested through development and lifespan.
 
Immune system phenotype.
 
Reproductive system phenotype.
 
Touch/vibrissae phenotype.
 
Skin/coat/nails phenotype.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Mukundan L, et al.
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med 15, 1266-72(2009).
 
Li Y, et al.
High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes. J Mol Cell Cardiol 47, 536-43(2009).
 
Karpe F & Ehrenborg EE.
PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function. Curr Opin Lipidol 20, 333-6(2009).
 
Zuo X, et al.
Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. J Natl Cancer Inst 101, 762-7(2009).
 
Burch LR, et al.
A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children. J Clin Endocrinol Metab 94, 2587-93(2009).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
zf-C4 (cl02596)
  Zinc finger, C4 type (two domains).
 
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Ppard includes H.sapiens PPARD and R.norvegicus Ppard.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Peroxisome proliferator-activated receptor delta
 
Peroxisome proliferator-activated receptor delta
 
Peroxisome proliferator activated receptor beta 2
 
Peroxisome proliferator activated receptor beta
 
Transcribed locus, strongly similar to XP_688284.2 PREDICTED: peroxisome pro...
 
Transcribed locus, strongly similar to NP_001091097.1 peroxisome proliferato...
 
Peroxisome proliferator-activated receptor delta
 
Transcribed locus, moderately similar to NP_001081310.1 peroxisome prolifera...
 
Peroxisome proliferator-activated receptor delta
 
MRNA, clone QccE-13705: similar to Homo sapiens peroxisome proliferative act...
 
Peroxisome proliferator activator receptor delta
 
Peroxisome proliferator-activated receptor beta
 
Peroxisome proliferator activated receptor delta/beta
 
Peroxisome proliferator activated receptor beta
 
Transcribed locus, strongly similar to NP_006229.1 peroxisome proliferative ...
 
Peroxisome proliferator-activated receptor
 
Transcribed locus, moderately similar to XP_688284.2 PREDICTED: peroxisome p...
 
Peroxisome proliferator activated receptor isoform b (PPAR)
 
Peroxisome proliferator-activated receptor delta
 
Peroxisome proliferator-activated receptor beta
 
Peroxisomal proliferator-activated receptor beta1A
 
Peroxisome proliferator-activated receptor beta2A
 
Peroxisome proliferator-activated receptor beta2B
 
Transcribed locus, moderately similar to NP_001117031.1 peroxisome prolifera...
 
Peroxisome proliferator-activated receptor delta
 
Peroxisome proliferators-activated receptor beta
 
Peroxisome proliferator-activated receptor delta
 
Peroxisome proliferator activated receptor beta